登録情報 データベース : PDB / ID : 6ym5 構造の表示 ダウンロードとリンクタイトル Crystal structure of BAY-091 with PIP4K2A 要素Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 詳細 キーワード TRANSFERASE / PIP4K2A機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
vesicle-mediated cholesterol transport / 1-phosphatidylinositol-5-phosphate 4-kinase / 1-phosphatidylinositol-5-phosphate 4-kinase activity / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process / Synthesis of PIPs in the nucleus / 1-phosphatidylinositol-4-phosphate 5-kinase activity / autophagosome-lysosome fusion / positive regulation of autophagosome assembly / megakaryocyte development / PI5P Regulates TP53 Acetylation ... vesicle-mediated cholesterol transport / 1-phosphatidylinositol-5-phosphate 4-kinase / 1-phosphatidylinositol-5-phosphate 4-kinase activity / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process / Synthesis of PIPs in the nucleus / 1-phosphatidylinositol-4-phosphate 5-kinase activity / autophagosome-lysosome fusion / positive regulation of autophagosome assembly / megakaryocyte development / PI5P Regulates TP53 Acetylation / Synthesis of PIPs at the plasma membrane / phosphatidylinositol phosphate biosynthetic process / photoreceptor outer segment / autophagosome / negative regulation of insulin receptor signaling pathway / photoreceptor inner segment / regulation of autophagy / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / lysosome / phosphorylation / protein homodimerization activity / nucleoplasm / ATP binding / plasma membrane / cytosol 類似検索 - 分子機能 Phosphatidylinositol-4-phosphate 5-kinase / : / Phosphatidylinositol-4-phosphate 5-kinase, core / Phosphatidylinositol-4-phosphate 5-kinase, N-terminal / Phosphatidylinositol-4-phosphate 5-Kinase / Phosphatidylinositol phosphate kinase (PIPK) domain profile. / Phosphatidylinositol phosphate kinases 類似検索 - ドメイン・相同性 Chem-OZ5 / PHOSPHATE ION / Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.5 Å 詳細データ登録者 Holton, S.J. / Wortmann, L. / Braeuer, N. / Irlbacher, H. / Weiske, J. / Lechner, C. / Meier, R. / Puetter, V. / Christ, C. / ter Laak, T. ...Holton, S.J. / Wortmann, L. / Braeuer, N. / Irlbacher, H. / Weiske, J. / Lechner, C. / Meier, R. / Puetter, V. / Christ, C. / ter Laak, T. / Lienau, P. / Lesche, R. / Nicke, B. / Bauser, M. / Haegebarth, A. / von Nussbaum, F. / Mumberg, D. / Lemos, C. 引用ジャーナル : J.Med.Chem. / 年 : 2021タイトル : Discovery and Characterization of the Potent and Highly Selective 1,7-Naphthyridine-Based Inhibitors BAY-091 and BAY-297 of the Kinase PIP4K2A.著者: Wortmann, L. / Brauer, N. / Holton, S.J. / Irlbacher, H. / Weiske, J. / Lechner, C. / Meier, R. / Karen, J. / Sioberg, C.B. / Putter, V. / Christ, C.D. / Ter Laak, A. / Lienau, P. / Lesche, R. ... 著者 : Wortmann, L. / Brauer, N. / Holton, S.J. / Irlbacher, H. / Weiske, J. / Lechner, C. / Meier, R. / Karen, J. / Sioberg, C.B. / Putter, V. / Christ, C.D. / Ter Laak, A. / Lienau, P. / Lesche, R. / Nicke, B. / Cheung, S.H. / Bauser, M. / Haegebarth, A. / von Nussbaum, F. / Mumberg, D. / Lemos, C. 履歴 登録 2020年4月7日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2021年4月14日 Provider : repository / タイプ : Initial release改定 1.1 2021年11月17日 Group : Data collection / Database referencesカテゴリ : citation / citation_author ... citation / citation_author / database_2 / pdbx_database_proc Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.2 2021年11月24日 Group : Data collection / Database referencesカテゴリ : citation / citation_author / pdbx_database_procItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID 改定 1.3 2024年1月24日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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