登録情報 | データベース: PDB / ID: 6y08 |
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タイトル | Mouse thymidylate synthase cocrystallized with dUMP and soaked in sulfamethoxazole |
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要素 | Thymidylate synthase |
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キーワード | TRANSFERASE / Fragment Screening / Fragment / Inhibitor / Thymidylate Synthase |
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機能・相同性 | 機能・相同性情報
Interconversion of nucleotide di- and triphosphates / uracil metabolic process / response to organophosphorus / intestinal epithelial cell maturation / response to folic acid / thymidylate synthase / response to vitamin A / sequence-specific mRNA binding / cartilage development / tetrahydrofolate interconversion ...Interconversion of nucleotide di- and triphosphates / uracil metabolic process / response to organophosphorus / intestinal epithelial cell maturation / response to folic acid / thymidylate synthase / response to vitamin A / sequence-specific mRNA binding / cartilage development / tetrahydrofolate interconversion / thymidylate synthase activity / folic acid binding / dTMP biosynthetic process / dTTP biosynthetic process / heterocyclic compound binding / developmental growth / response to glucocorticoid / liver regeneration / mRNA regulatory element binding translation repressor activity / response to cytokine / response to progesterone / circadian rhythm / response to toxic substance / regulation of translation / methylation / response to ethanol / mitochondrial inner membrane / mitochondrial matrix / response to xenobiotic stimulus / mRNA binding / protein homodimerization activity / mitochondrion / nucleus / cytoplasm / cytosol類似検索 - 分子機能 Thymidylate synthase/dCMP hydroxymethylase / Thymidylate synthase, active site / Thymidylate synthase active site. / Thymidylate synthase / Thymidylate synthase/dCMP hydroxymethylase domain / Thymidylate synthase/dCMP hydroxymethylase superfamily / Thymidylate synthase類似検索 - ドメイン・相同性 Sulfamethoxazole / 2'-DEOXYURIDINE 5'-MONOPHOSPHATE / Thymidylate synthase類似検索 - 構成要素 |
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生物種 | Mus musculus (ハツカネズミ) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.297 Å |
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データ登録者 | Maj, P. / Jarmula, A. / Wilk, P. / Weiss, M.S. / Rode, W. |
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資金援助 | ポーランド, 1件 組織 | 認可番号 | 国 |
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Polish National Science Centre | 2016/21/B/NZ1/00288 | ポーランド |
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引用 | ジャーナル: To Be Published タイトル: Mouse thymidylate synthase cocrystallized with dUMP and soaked in sulfamethoxazole 著者: Maj, P. / Jarmula, A. / Wilk, P. / Weiss, M.S. / Rode, W. |
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履歴 | 登録 | 2020年2月6日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2021年2月17日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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