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Yorodumi- PDB-6xv0: lauric acid functionalized hexamolybdoaluminate bound to human se... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6xv0 | ||||||
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Title | lauric acid functionalized hexamolybdoaluminate bound to human serum albumin | ||||||
Components | Serum albumin | ||||||
Keywords | TRANSPORT PROTEIN / serum protein / complex / polyoxometalate | ||||||
Function / homology | Function and homology information cellular response to calcium ion starvation / exogenous protein binding / Ciprofloxacin ADME / enterobactin binding / Heme biosynthesis / HDL remodeling / negative regulation of mitochondrial depolarization / Prednisone ADME / Heme degradation / Aspirin ADME ...cellular response to calcium ion starvation / exogenous protein binding / Ciprofloxacin ADME / enterobactin binding / Heme biosynthesis / HDL remodeling / negative regulation of mitochondrial depolarization / Prednisone ADME / Heme degradation / Aspirin ADME / antioxidant activity / toxic substance binding / small molecule binding / Scavenging of heme from plasma / Recycling of bile acids and salts / cellular response to starvation / platelet alpha granule lumen / fatty acid binding / Post-translational protein phosphorylation / Cytoprotection by HMOX1 / Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) / pyridoxal phosphate binding / Platelet degranulation / protein-folding chaperone binding / blood microparticle / copper ion binding / endoplasmic reticulum lumen / Golgi apparatus / endoplasmic reticulum / protein-containing complex / DNA binding / extracellular space / extracellular exosome / extracellular region / identical protein binding / nucleus / cytoplasm Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 3 Å | ||||||
Authors | Bijelic, A. / Dobrov, A. / Roller, A. / Rompel, A. | ||||||
Funding support | 1items
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Citation | Journal: Inorg.Chem. / Year: 2020 Title: Binding of a Fatty Acid-Functionalized Anderson-Type Polyoxometalate to Human Serum Albumin. Authors: Bijelic, A. / Dobrov, A. / Roller, A. / Rompel, A. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6xv0.cif.gz | 253.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6xv0.ent.gz | 194.3 KB | Display | PDB format |
PDBx/mmJSON format | 6xv0.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/xv/6xv0 ftp://data.pdbj.org/pub/pdb/validation_reports/xv/6xv0 | HTTPS FTP |
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-Related structure data
Related structure data | 1n5uS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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1 |
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Unit cell |
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-Components
#1: Protein | Mass: 66571.219 Da / Num. of mol.: 1 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P02768 | ||||
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#2: Chemical | ChemComp-MYR / #3: Chemical | Has ligand of interest | Y | |
-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION / Number of used crystals: 1 |
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-Sample preparation
Crystal | Density Matthews: 2.48 Å3/Da / Density % sol: 50.37 % |
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Crystal grow | Temperature: 293 K / Method: vapor diffusion, hanging drop / pH: 7 Details: 50 mM potassium phosphate (pH 7.0), 150 mM KCl, 22-26% PEG3350, 125 mg/ml protein |
-Data collection
Diffraction | Mean temperature: 100 K / Serial crystal experiment: N |
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Diffraction source | Source: SEALED TUBE / Type: BRUKER D8 QUEST / Wavelength: 1.54184 Å |
Detector | Type: Bruker PHOTON II / Detector: PIXEL / Date: Sep 18, 2019 |
Radiation | Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.54184 Å / Relative weight: 1 |
Reflection | Resolution: 3→31.89 Å / Num. obs: 13029 / % possible obs: 96.13 % / Redundancy: 4.3 % / CC1/2: 0.995 / CC star: 0.999 / Net I/σ(I): 14.37 |
Reflection shell | Resolution: 3→3.107 Å / Num. unique obs: 1252 / CC1/2: 0.905 / CC star: 0.975 |
-Processing
Software |
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Refinement | Method to determine structure: MOLECULAR REPLACEMENT Starting model: 1N5U Resolution: 3→31.89 Å / Cross valid method: FREE R-VALUE
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Displacement parameters | Biso mean: 48.42 Å2 | ||||||||||||||||||||||||
Refinement step | Cycle: LAST / Resolution: 3→31.89 Å
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Refine LS restraints |
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