登録情報 データベース : PDB / ID : 6xf4 構造の表示 ダウンロードとリンクタイトル Crystal structure of STING REF variant in complex with E7766 要素Stimulator of interferon genes protein 詳細 キーワード IMMUNE SYSTEM / Stimulator of interferon genes (STING) / REF variant / E7766 / Agonist / Macrocycle機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway ... STING complex / STAT6-mediated induction of chemokines / protein localization to endoplasmic reticulum / serine/threonine protein kinase complex / proton channel activity / 2',3'-cyclic GMP-AMP binding / STING mediated induction of host immune responses / cyclic-di-GMP binding / IRF3-mediated induction of type I IFN / positive regulation of type I interferon-mediated signaling pathway / cGAS/STING signaling pathway / reticulophagy / pattern recognition receptor signaling pathway / cytoplasmic pattern recognition receptor signaling pathway / cellular response to exogenous dsRNA / autophagosome membrane / antiviral innate immune response / positive regulation of macroautophagy / cellular response to organic cyclic compound / autophagosome assembly / autophagosome / positive regulation of type I interferon production / cellular response to interferon-beta / signaling adaptor activity / positive regulation of defense response to virus by host / activation of innate immune response / Regulation of innate immune responses to cytosolic DNA / positive regulation of interferon-beta production / endoplasmic reticulum-Golgi intermediate compartment membrane / secretory granule membrane / cytoplasmic vesicle membrane / positive regulation of DNA-binding transcription factor activity / peroxisome / SARS-CoV-1 activates/modulates innate immune responses / positive regulation of protein binding / protein complex oligomerization / regulation of inflammatory response / defense response to virus / RNA polymerase II-specific DNA-binding transcription factor binding / mitochondrial outer membrane / endosome / Golgi membrane / innate immune response / ubiquitin protein ligase binding / Neutrophil degranulation / endoplasmic reticulum membrane / protein kinase binding / SARS-CoV-2 activates/modulates innate and adaptive immune responses / perinuclear region of cytoplasm / protein homodimerization activity / positive regulation of transcription by RNA polymerase II / nucleoplasm / identical protein binding / plasma membrane / cytosol 類似検索 - 分子機能 : / Stimulator of interferon genes protein / Stimulator of interferon genes protein, C-terminal domain superfamily / Transmembrane protein 173 類似検索 - ドメイン・相同性 Chem-V5V / Stimulator of interferon genes protein 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.77 Å 詳細データ登録者 Chen, Y. / Wang, J.Y. / Kim, D.-S. 引用ジャーナル : Chemmedchem / 年 : 2021タイトル : E7766, a Macrocycle-Bridged Stimulator of Interferon Genes (STING) Agonist with Potent Pan-Genotypic Activity.著者: Kim, D.S. / Endo, A. / Fang, F.G. / Huang, K.C. / Bao, X. / Choi, H.W. / Majumder, U. / Shen, Y.Y. / Mathieu, S. / Zhu, X. / Sanders, K. / Noland, T. / Hao, M.H. / Chen, Y. / Wang, J.Y. / ... 著者 : Kim, D.S. / Endo, A. / Fang, F.G. / Huang, K.C. / Bao, X. / Choi, H.W. / Majumder, U. / Shen, Y.Y. / Mathieu, S. / Zhu, X. / Sanders, K. / Noland, T. / Hao, M.H. / Chen, Y. / Wang, J.Y. / Yasui, S. / TenDyke, K. / Wu, J. / Ingersoll, C. / Loiacono, K.A. / Hutz, J.E. / Sarwar, N. 履歴 登録 2020年6月15日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2021年2月17日 Provider : repository / タイプ : Initial release改定 1.1 2021年6月16日 Group : Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.2 2024年3月6日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id 改定 1.3 2024年4月3日 Group : Refinement description / カテゴリ : pdbx_initial_refinement_model
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