Entry Database : PDB / ID : 5c2j Structure visualization Downloads & linksTitle Complex structure of the GAP domain of MgcRacGAP and Cdc42 ComponentsCell division control protein 42 homolog Rac GTPase-activating protein 1 DetailsKeywords HYDROLASE ACTIVATOR/SIGNALING PROTEIN / GTPase activation / Complex / small G-protein / HYDROLASE ACTIVATOR-SIGNALING PROTEIN complexFunction / homology Function and homology informationFunction Domain/homology Component
RHO GTPases activate KTN1 / RHOV GTPase cycle / centralspindlin complex / DCC mediated attractive signaling / CD28 dependent Vav1 pathway / RHOQ GTPase cycle / RHOU GTPase cycle / RAC3 GTPase cycle / RHO GTPases activate PAKs / RAC2 GTPase cycle ... RHO GTPases activate KTN1 / RHOV GTPase cycle / centralspindlin complex / DCC mediated attractive signaling / CD28 dependent Vav1 pathway / RHOQ GTPase cycle / RHOU GTPase cycle / RAC3 GTPase cycle / RHO GTPases activate PAKs / RAC2 GTPase cycle / establishment or maintenance of apical/basal cell polarity / CDC42 GTPase cycle / G beta:gamma signalling through CDC42 / actomyosin contractile ring assembly / GPVI-mediated activation cascade / sulfate transport / EPHB-mediated forward signaling / RHO GTPases Activate WASPs and WAVEs / EGFR downregulation / GBD domain binding / submandibular salivary gland formation / actin filament branching / Golgi transport complex / RAC1 GTPase cycle / positive regulation of pinocytosis / modification of synaptic structure / endothelin receptor signaling pathway involved in heart process / RHOG GTPase cycle / Cdc42 protein signal transduction / cardiac neural crest cell migration involved in outflow tract morphogenesis / mitotic spindle midzone assembly / positive regulation of synapse structural plasticity / dendritic cell migration / RHO GTPases activate IQGAPs / storage vacuole / positive regulation of epithelial cell proliferation involved in lung morphogenesis / apolipoprotein A-I receptor binding / neuron fate determination / RHO GTPases Activate Formins / modulation by host of viral process / GTP-dependent protein binding / organelle transport along microtubule / regulation of attachment of spindle microtubules to kinetochore / positive regulation of pseudopodium assembly / Regulation of actin dynamics for phagocytic cup formation / nucleus localization / MAPK6/MAPK4 signaling / cardiac conduction system development / heart process / Factors involved in megakaryocyte development and platelet production / establishment of Golgi localization / leading edge membrane / regulation of filopodium assembly / neuropilin signaling pathway / positive regulation of intracellular protein transport / Myogenesis / cell junction assembly / filopodium assembly / establishment of epithelial cell apical/basal polarity / mitogen-activated protein kinase kinase kinase binding / regulation of modification of postsynaptic structure / dendritic spine morphogenesis / VEGFA-VEGFR2 Pathway / embryonic heart tube development / gamma-tubulin binding / thioesterase binding / regulation of stress fiber assembly / RHOD GTPase cycle / Flemming body / Kinesins / nuclear migration / regulation of lamellipodium assembly / adherens junction organization / sprouting angiogenesis / regulation of small GTPase mediated signal transduction / positive regulation of filopodium assembly / COPI-dependent Golgi-to-ER retrograde traffic / regulation of postsynapse organization / endosomal transport / regulation of mitotic nuclear division / establishment or maintenance of cell polarity / RHOB GTPase cycle / phagocytosis, engulfment / heart contraction / positive regulation of DNA replication / RHOC GTPase cycle / beta-tubulin binding / cell leading edge / Golgi organization / positive regulation of cytokinesis / phosphatidylinositol-3,4,5-trisphosphate binding / lamellipodium membrane / cleavage furrow / CDC42 GTPase cycle / regulation of embryonic development / Rho protein signal transduction / mitotic cytokinesis / RHOA GTPase cycle / alpha-tubulin binding / neuroblast proliferation Similarity search - Function Phosphatidylinositol 3-kinase; Chain A / Rho GTPase activation protein / Cdc42 / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Small GTPase Rho / small GTPase Rho family profile. / Phorbol esters/diacylglycerol binding domain (C1 domain) ... Phosphatidylinositol 3-kinase; Chain A / Rho GTPase activation protein / Cdc42 / Rho GTPase-activating protein domain / RhoGAP domain / Rho GTPase-activating proteins domain profile. / GTPase-activator protein for Rho-like GTPases / Small GTPase Rho / small GTPase Rho family profile. / Phorbol esters/diacylglycerol binding domain (C1 domain) / Rho GTPase activation protein / Zinc finger phorbol-ester/DAG-type signature. / Zinc finger phorbol-ester/DAG-type profile. / Protein kinase C conserved region 1 (C1) domains (Cysteine-rich domains) / Protein kinase C-like, phorbol ester/diacylglycerol-binding domain / C1-like domain superfamily / Rho (Ras homology) subfamily of Ras-like small GTPases / Ras subfamily of RAS small GTPases / Small GTPase / Ras family / Rab subfamily of small GTPases / Small GTP-binding protein domain / P-loop containing nucleotide triphosphate hydrolases / Rossmann fold / P-loop containing nucleoside triphosphate hydrolase / Orthogonal Bundle / 3-Layer(aba) Sandwich / Mainly Alpha / Alpha Beta Similarity search - Domain/homology ALUMINUM FLUORIDE / GUANOSINE-5'-DIPHOSPHATE / Cell division control protein 42 homolog / Rac GTPase-activating protein 1 Similarity search - ComponentBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Murayama, K. / Kato-Murayama, M. / Hosaka, T. / Kitamura, T. / Yokoyama, S. / Shirouzu, M. CitationJournal : To Be Published Title : Structural basis of G-protein target alternation of MgcRacGAP by phospholylationAuthors : Murayama, K. / Kato-Murayama, M. / Hosaka, T. / Kawashima, T. / Kitamura, T. / Yokoyama, S. / Shirouzu, M. History Deposition Jun 16, 2015 Deposition site : RCSB / Processing site : PDBJRevision 1.0 Jun 22, 2016 Provider : repository / Type : Initial releaseRevision 1.1 Feb 19, 2020 Group : Data collection / Derived calculations / Category : diffrn_source / pdbx_struct_oper_listItem : _diffrn_source.pdbx_synchrotron_site / _pdbx_struct_oper_list.symmetry_operationRevision 1.2 Nov 8, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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