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- PDB-6xco: Immune receptor complex -

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ID or keywords:

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Basic information

Entry
Database: PDB / ID: 6xco
TitleImmune receptor complex
Components
  • (T-CELL-RECEPTOR, A1.9- ...) x 2
  • Hybrid Insulin Peptide, MHC class II HLA-DQ-beta-1 fusion
  • MHC class II HLA-DQ-alpha chain
KeywordsIMMUNE SYSTEM / Complex
Function / homology
Function and homology information


antigen processing and presentation of peptide or polysaccharide antigen via MHC class II / MHC class II protein complex / adaptive immune response / endosome membrane / lysosomal membrane
Similarity search - Function
MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site ...MHC class II, beta chain, N-terminal / Class II histocompatibility antigen, beta domain / Class II histocompatibility antigen, beta domain / MHC class II, alpha chain, N-terminal / Class II histocompatibility antigen, alpha domain / Class II histocompatibility antigen, alpha domain / MHC class II, alpha/beta chain, N-terminal / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
CACODYLATE ION / MHC class II HLA-DQ-beta-1 / MHC class II HLA-DQ-alpha chain
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.9 Å
AuthorsTran, T.M. / Faridi, P. / Lim, J.J. / Ting, T.Y. / Onwukwe, G. / Bhattacharjee, P. / Jones, M.C. / Tresoldi, E. / Cameron, J.F. / La-Gruta, L.N. ...Tran, T.M. / Faridi, P. / Lim, J.J. / Ting, T.Y. / Onwukwe, G. / Bhattacharjee, P. / Jones, M.C. / Tresoldi, E. / Cameron, J.F. / La-Gruta, L.N. / Purcell, W.A. / Mannering, I.S. / Rossjohn, J. / Reid, H.H.
Funding support Australia, 1items
OrganizationGrant numberCountry
National Health and Medical Research Council (NHMRC, Australia)APP1123586 Australia
CitationJournal: Nat Commun / Year: 2021
Title: T cell receptor recognition of hybrid insulin peptides bound to HLA-DQ8.
Authors: Tran, M.T. / Faridi, P. / Lim, J.J. / Ting, Y.T. / Onwukwe, G. / Bhattacharjee, P. / Jones, C.M. / Tresoldi, E. / Cameron, F.J. / La Gruta, N.L. / Purcell, A.W. / Mannering, S.I. / Rossjohn, J. / Reid, H.H.
History
DepositionJun 8, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jul 14, 2021Provider: repository / Type: Initial release
Revision 1.1Jan 26, 2022Group: Database references / Category: citation / citation_author / database_2
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.2Oct 18, 2023Group: Data collection / Refinement description
Category: chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
Revision 1.3Oct 9, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature / Item: _pdbx_entry_details.has_protein_modification

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: MHC class II HLA-DQ-alpha chain
B: Hybrid Insulin Peptide, MHC class II HLA-DQ-beta-1 fusion
D: T-CELL-RECEPTOR, A1.9-alpha chain
E: T-CELL-RECEPTOR, A1.9-beta chain
hetero molecules


Theoretical massNumber of molelcules
Total (without water)99,16314
Polymers97,8094
Non-polymers1,35310
Water1,20767
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: surface plasmon resonance
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area14700 Å2
ΔGint-44 kcal/mol
Surface area35910 Å2
MethodPISA
Unit cell
Length a, b, c (Å)69.288, 104.310, 69.316
Angle α, β, γ (deg.)90.000, 114.914, 90.000
Int Tables number4
Space group name H-MP1211
Space group name HallP2yb
Symmetry operation#1: x,y,z
#2: -x,y+1/2,-z

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Components

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Protein , 2 types, 2 molecules AB

#1: Protein MHC class II HLA-DQ-alpha chain


Mass: 21929.256 Da / Num. of mol.: 1 / Mutation: I72C
Source method: isolated from a genetically manipulated source
Details: Class II histocompatibility antigen, alpha domain / Source: (gene. exp.) Homo sapiens (human) / Tissue: Skin, lymphoid, lungs, stomach and intestines / Cell: B Lymphocytes, dendritic cells, macrophages / Gene: HLA-DQA1 / Organ: Parenchyma / Plasmid: pZip3 / Cell line (production host): High Five (BTI-Tn-5B1-4) / Organ (production host): ovary / Production host: Trichoplusia ni (cabbage looper) / Strain (production host): DH10B / Tissue (production host): cabbage looper ovarian / References: UniProt: Q30069
#2: Protein Hybrid Insulin Peptide, MHC class II HLA-DQ-beta-1 fusion


Mass: 26070.969 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Details: A fusion of proinsulin C-peptide fragments and IAPP2 fragments
Source: (gene. exp.) Homo sapiens (human) / Tissue: Islets of Langerhans / Cell: Beta cells / Organ: Pancreas / Plasmid: pZip3 / Gene: HLA-DQB1 / Cell (production host): cabbage looper ovarian / Cell line (production host): High Five (BTI-Tn-5B1-4) / Organ (production host): ovary / Production host: Trichoplusia ni (cabbage looper) / Strain (production host): DH10B / References: UniProt: O19707

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T-CELL-RECEPTOR, A1.9- ... , 2 types, 2 molecules DE

#3: Protein T-CELL-RECEPTOR, A1.9-alpha chain


Mass: 22723.150 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Details: human islet-infiltrating CD4+ T cell clone isolated from the residual pancreatic islets from of a deceased organ donor who had T1D
Source: (gene. exp.) Homo sapiens (human) / Tissue: Islets of Langerhans / Cell: Beta cells / Gene: TRAV20*02 / Organ: Pancreas / Plasmid: pET30 / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3)
#4: Protein T-CELL-RECEPTOR, A1.9-beta chain


Mass: 27086.068 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Details: human islet-infiltrating CD4+ T cell clone isolated from the residual pancreatic islets from of a deceased organ donor who had T1D
Source: (gene. exp.) Homo sapiens (human) / Tissue: Islets of Langerhans / Cell: Beta cells / Gene: TRBV5-1*01 / Organ: Pancreas / Plasmid: pET30 / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3)

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Sugars , 1 types, 3 molecules

#5: Sugar ChemComp-NAG / 2-acetamido-2-deoxy-beta-D-glucopyranose / N-acetyl-beta-D-glucosamine / 2-acetamido-2-deoxy-beta-D-glucose / 2-acetamido-2-deoxy-D-glucose / 2-acetamido-2-deoxy-glucose / N-ACETYL-D-GLUCOSAMINE


Type: D-saccharide, beta linking / Mass: 221.208 Da / Num. of mol.: 3
Source method: isolated from a genetically manipulated source
Formula: C8H15NO6
IdentifierTypeProgram
DGlcpNAcbCONDENSED IUPAC CARBOHYDRATE SYMBOLGMML 1.0
N-acetyl-b-D-glucopyranosamineCOMMON NAMEGMML 1.0
b-D-GlcpNAcIUPAC CARBOHYDRATE SYMBOLPDB-CARE 1.0
GlcNAcSNFG CARBOHYDRATE SYMBOLGMML 1.0

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Non-polymers , 3 types, 74 molecules

#6: Chemical
ChemComp-GOL / GLYCEROL / GLYCERIN / PROPANE-1,2,3-TRIOL


Mass: 92.094 Da / Num. of mol.: 6 / Source method: obtained synthetically / Formula: C3H8O3
#7: Chemical ChemComp-CAC / CACODYLATE ION / dimethylarsinate


Mass: 136.989 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C2H6AsO2
#8: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 67 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN
Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.37 Å3/Da / Density % sol: 48.16 %
Crystal growTemperature: 293.15 K / Method: vapor diffusion, hanging drop / pH: 5.5
Details: 0.1 M calcium acetate, 0.1 M sodium cacodylate pH 5.5, 13% polyethylene glycol (PEG) 20,000

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: Australian Synchrotron / Beamline: MX2 / Wavelength: 0.9537 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Mar 26, 2019
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.9537 Å / Relative weight: 1
ReflectionResolution: 2.9→40.14 Å / Num. obs: 19889 / % possible obs: 99.94 % / Redundancy: 2 % / Biso Wilson estimate: 49.79 Å2 / CC1/2: 0.985 / CC star: 0.996 / Rmerge(I) obs: 0.0853 / Rpim(I) all: 0.0853 / Rrim(I) all: 0.1206 / Net I/σ(I): 5.7
Reflection shellResolution: 2.9→3.004 Å / Rmerge(I) obs: 0.4017 / Mean I/σ(I) obs: 1.94 / Num. unique obs: 1983 / CC1/2: 0.724 / Rpim(I) all: 0.4017 / Rrim(I) all: 0.5681

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Processing

Software
NameVersionClassification
PHENIX1.15_3459refinement
XDSdata reduction
Aimlessdata scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 4Z7U

4z7u


Resolution: 2.9→40.14 Å / SU ML: 0.3952 / Cross valid method: FREE R-VALUE / σ(F): 1.34 / Phase error: 27.9426
Stereochemistry target values: GeoStd + Monomer Library + CDL v1.2
RfactorNum. reflection% reflection
Rfree0.2471 967 4.86 %
Rwork0.2066 18919 -
obs0.2086 19886 99.98 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å / Solvent model: FLAT BULK SOLVENT MODEL
Displacement parametersBiso mean: 56.29 Å2
Refinement stepCycle: LAST / Resolution: 2.9→40.14 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6297 0 83 67 6447
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00426529
X-RAY DIFFRACTIONf_angle_d0.56258883
X-RAY DIFFRACTIONf_chiral_restr0.0464983
X-RAY DIFFRACTIONf_plane_restr0.00491158
X-RAY DIFFRACTIONf_dihedral_angle_d19.17222358
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.9-3.050.31921580.29412647X-RAY DIFFRACTION99.96
3.05-3.240.28791170.25332712X-RAY DIFFRACTION100
3.24-3.490.26841080.22192718X-RAY DIFFRACTION100
3.49-3.850.26511260.20332718X-RAY DIFFRACTION100
3.85-4.40.21641560.18092687X-RAY DIFFRACTION99.96
4.4-5.540.21381740.17342664X-RAY DIFFRACTION100
5.54-40.140.25431280.20832773X-RAY DIFFRACTION99.93
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
14.53240.3348-0.96650.2524-0.57851.53920.00780.1141-0.30480.0137-0.0663-0.23180.34950.17320.04530.5140.0185-0.22580.5680.01960.5052-10.4525.072-14.9
21.11870.14980.42751.6635-0.64321.6218-0.0739-0.236-0.08970.1479-0.1608-0.04810.14690.1133-0.05880.57040.0171-0.37540.4723-0.04850.4312-14.64330.076-7.473
30.7925-0.84640.50061.09660.00891.71240.0225-0.27950.08580.1770.16380.1156-0.1002-0.12150.03390.6798-0.0702-0.30930.4958-0.01940.4286-17.75338.325-4.624
41.1731-0.61940.63470.345-0.28791.0876-0.07020.03560.1271-0.0621-0.1468-0.02270.10390.0678-0.01970.4912-0.0308-0.26730.50250.02180.4447-20.42332.018-13.125
52.0679-0.4533.62190.103-0.79476.34570.38710.2905-0.75920.13120.1822-0.06360.55320.1556-0.56590.7924-0.1279-0.380.64150.05890.6016-20.8239.135-6.181
62.8878-0.55380.36030.8452-1.22391.8132-0.1618-0.30950.23240.21810.063-0.3252-0.18940.1188-0.0170.62170.03-0.28470.69730.01250.48852.42126.80511.042
72.12130.75842.04231.6381.42383.0089-0.0427-0.2764-0.03830.2104-0.0258-0.1090.2239-0.0376-0.09820.6802-0.0219-0.30560.5940.05910.44-10.18221.636.017
80.9644-0.0923-0.48881.9646-2.02123.0071-0.097-0.4657-0.03430.39030.1626-0.0055-0.1002-0.5144-0.10040.70320.0889-0.28860.8512-0.04750.5783-11.65129.09115.394
91.1211-0.06480.79120.1519-0.44111.59540.1095-0.1376-0.22720.1550.0189-0.1290.32160.0929-0.11320.5184-0.0266-0.57570.5202-0.02320.5452-10.71320.962-6.454
102.1983-0.20860.46061.5510.00750.09670.0194-0.79490.06510.51750.1587-0.1835-0.0163-0.2352-0.07740.6111-0.0642-1.06330.68280.02410.0928-3.73328.12814.997
111.16520.2517-0.35512.4587-0.09661.26150.1963-0.6475-0.03260.42550.1086-0.22370.0771-0.1638-0.17780.9001-0.046-0.46070.67720.18860.4766-9.45216.90512.075
122.2907-0.17180.45721.4102-0.07541.83890.1402-0.2571-0.31840.0251-0.1972-0.07540.13870.2345-0.05330.5480.0433-0.27320.4973-0.01160.3551-14.03321.333-16.194
131.31660.2633-0.13781.6512-0.89731.74620.07980.0234-0.4482-0.0324-0.1568-0.12610.29460.228-0.1080.62480.0199-0.79560.5094-0.05030.2303-15.98916.33-24.07
141.48520.36440.21210.8338-1.49253.22160.25510.4149-0.2554-0.3738-0.1310.07610.3206-0.0202-0.1420.8417-0.1734-0.89180.3234-0.27290.1946-24.99118.671-29.821
155.01420.39562.15453.24421.73693.7320.03920.32520.066-0.2332-0.01130.13770.00280.09470.040.43180.1075-0.68120.54620.07070.2099-17.65930.576-30.131
163.0008-1.07471.91190.99020.56223.8506-0.02970.19030.3551-0.05260.0609-0.2565-0.26940.38890.10.5362-0.0473-0.25450.57230.0390.4548-5.29138.566-20.454
173.9161-1.63242.52251.5798-0.39982.38150.00160.01360.2190.24430.2063-0.3-0.09440.00280.07890.5487-0.0259-0.34890.5862-0.03040.534610.26931.6471.112
185.2132-2.39411.88851.7498-0.86791.66730.12830.32280.0413-0.0148-0.2035-0.30930.10260.44060.02420.6329-0.0025-0.33710.62970.00890.604616.82426.725-3.077
193.1573-0.76581.17761.2471-0.17661.1645-0.04760.26210.0012-0.1298-0.0313-0.36630.03220.2798-0.00360.5497-0.0448-0.28970.65170.01110.574112.46923.497-0.398
200.93820.2184-0.35762.04090.0810.49310.1339-0.259-0.33740.42890.0908-0.41110.26690.2212-0.10060.70680.0391-0.35540.6449-0.07650.759819.99821.2137.234
211.9456-1.16151.2882.3313-1.90332.83490.0520.0590.14580.2927-0.1152-0.38970.07470.37540.11760.6797-0.0305-0.52910.6676-0.02090.805920.62131.4551.458
223.89932.1181.77915.54571.16562.68660.0408-0.0681-0.34830.1782-0.2224-0.01890.223-0.2446-0.07940.5593-0.0171-0.1970.5563-0.02420.4162-22.04230.33-20.783
232.2781-0.55051.04941.8653-0.77611.2753-0.2370.1250.1738-0.21540.0213-0.1389-0.43190.19180.1930.5947-0.0015-0.22240.51820.01180.4464-25.23250.393-37.338
242.1150.10871.09081.3504-0.562.30340.12660.54830.1214-0.27370.0928-0.11450.10270.34160.08460.59160.0473-0.29670.60790.00870.4603-23.25543.329-39.77
251.2027-0.58750.2931.146-1.19922.86040.00820.20680.26660.1722-0.06480.21510.1377-0.03140.01440.4854-0.0736-0.65190.54790.05160.1999-29.48346.789-35.23
262.038-0.63221.52511.8499-0.79872.58770.01140.2828-0.1243-0.155-0.08250.26420.1349-0.07570.17680.6259-0.022-0.28920.5446-0.00440.5466-51.5261.003-55.79
271.99960.42750.14651.0363-0.11721.89610.0750.16040.2520.0161-0.0124-0.186-0.32840.39330.12420.688-0.0037-0.31990.6482-0.00840.602-49.57263.692-52.402
281.7641-0.72540.31951.0426-0.04041.13440.406-0.13490.04610.40310.22350.3962-0.5238-0.4203-0.01190.3321-0.0991-0.47340.6481-0.04980.3186-45.80240.567-25.095
291.0813-0.73850.65960.6369-0.24670.9594-0.0551-0.31490.05320.02660.040.01750.0043-0.1432-0.02010.5678-0.0592-0.19740.56710.03970.4571-38.38139.882-18.113
300.955-1.08520.64321.2347-0.77340.5664-0.1657-0.4251-0.00040.2780.11210.1204-0.1068-0.25560.01370.53380.0104-0.19640.7441-0.01870.5013-47.64447.767-18.09
310.25660.22610.53851.2288-0.12781.56410.0846-0.0923-0.13650.0563-0.05740.11690.03850.1482-0.00370.46350.0015-0.22430.52390.01770.4271-36.07337.787-28.09
322.336-0.62231.61720.7604-1.0491.7456-0.0941-0.52080.41020.20880.00780.2314-0.3778-0.37340.06370.67630.0105-0.28120.6675-0.08620.4834-57.60354.424-26.944
333.12970.1344-1.32931.6398-1.70383.8430.16230.2130.1856-0.2666-0.00430.129-0.2932-0.09650.00510.7050.0189-0.43030.5739-0.0620.5763-59.6158.113-60.377
340.7853-0.3645-0.04390.63960.62141.8529-0.151-0.1464-0.08540.28010.00480.2335-0.05840.11520.03890.60290.0326-0.40050.5673-0.0140.4872-57.12252.167-45.684
351.7191-0.28840.24471.37410.12191.1350.1658-0.10010.14420.32170.2249-0.0264-0.28260.12030.00920.6815-0.0233-0.27960.6277-0.04130.5714-53.53255.765-42.752
360.8049-0.32170.73630.2702-0.16621.77050.03770.07-0.124-0.061-0.04730.09410.0924-0.01210.01840.5990.0128-0.28560.5672-0.06330.5376-59.69449.741-54.707
371.6032-0.4550.76210.95310.15012.9256-0.1608-0.3334-0.10690.0965-0.13210.20170.0254-0.3214-0.04070.5194-0.056-0.22370.66020.03120.5999-66.48249.259-36.099
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 0 through 15 )A0 - 15
2X-RAY DIFFRACTION2chain 'A' and (resid 16 through 35 )A16 - 35
3X-RAY DIFFRACTION3chain 'A' and (resid 36 through 45 )A36 - 45
4X-RAY DIFFRACTION4chain 'A' and (resid 46 through 76 )A46 - 76
5X-RAY DIFFRACTION5chain 'A' and (resid 77 through 87 )A77 - 87
6X-RAY DIFFRACTION6chain 'A' and (resid 88 through 102 )A88 - 102
7X-RAY DIFFRACTION7chain 'A' and (resid 103 through 123 )A103 - 123
8X-RAY DIFFRACTION8chain 'A' and (resid 124 through 134 )A124 - 134
9X-RAY DIFFRACTION9chain 'A' and (resid 135 through 146 )A135 - 146
10X-RAY DIFFRACTION10chain 'A' and (resid 147 through 160 )A147 - 160
11X-RAY DIFFRACTION11chain 'A' and (resid 161 through 180 )A161 - 180
12X-RAY DIFFRACTION12chain 'B' and (resid 43 through 74 )B43 - 74
13X-RAY DIFFRACTION13chain 'B' and (resid 75 through 96 )B75 - 96
14X-RAY DIFFRACTION14chain 'B' and (resid 97 through 106 )B97 - 106
15X-RAY DIFFRACTION15chain 'B' and (resid 107 through 119 )B107 - 119
16X-RAY DIFFRACTION16chain 'B' and (resid 120 through 130 )B120 - 130
17X-RAY DIFFRACTION17chain 'B' and (resid 131 through 164 )B131 - 164
18X-RAY DIFFRACTION18chain 'B' and (resid 165 through 175 )B165 - 175
19X-RAY DIFFRACTION19chain 'B' and (resid 176 through 196 )B176 - 196
20X-RAY DIFFRACTION20chain 'B' and (resid 197 through 212 )B197 - 212
21X-RAY DIFFRACTION21chain 'B' and (resid 213 through 231 )B213 - 231
22X-RAY DIFFRACTION22chain 'B' and (resid -2 through 12 )B-2 - 12
23X-RAY DIFFRACTION23chain 'D' and (resid 3 through 44 )D3 - 44
24X-RAY DIFFRACTION24chain 'D' and (resid 45 through 91 )D45 - 91
25X-RAY DIFFRACTION25chain 'D' and (resid 92 through 120 )D92 - 120
26X-RAY DIFFRACTION26chain 'D' and (resid 121 through 152 )D121 - 152
27X-RAY DIFFRACTION27chain 'D' and (resid 153 through 207 )D153 - 207
28X-RAY DIFFRACTION28chain 'E' and (resid 3 through 45 )E3 - 45
29X-RAY DIFFRACTION29chain 'E' and (resid 46 through 86 )E46 - 86
30X-RAY DIFFRACTION30chain 'E' and (resid 87 through 99 )E87 - 99
31X-RAY DIFFRACTION31chain 'E' and (resid 100 through 118 )E100 - 118
32X-RAY DIFFRACTION32chain 'E' and (resid 119 through 133 )E119 - 133
33X-RAY DIFFRACTION33chain 'E' and (resid 134 through 149 )E134 - 149
34X-RAY DIFFRACTION34chain 'E' and (resid 150 through 171 )E150 - 171
35X-RAY DIFFRACTION35chain 'E' and (resid 172 through 197 )E172 - 197
36X-RAY DIFFRACTION36chain 'E' and (resid 198 through 224 )E198 - 224
37X-RAY DIFFRACTION37chain 'E' and (resid 225 through 253 )E225 - 253

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