登録情報 | データベース: PDB / ID: 6wh8 |
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タイトル | The structure of NTMT1 in complex with compound BM-30 |
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要素 | - 4HP-PRO-LYS-ARG-NH2, BM-30
- N-terminal Xaa-Pro-Lys N-methyltransferase 1
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キーワード | TRANSFERASE / methyltransferase / enzyme / inhibitor complex / transferase-transferase inhibitor complex |
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機能・相同性 | 機能・相同性情報
N-terminal peptidyl-glycine methylation / N-terminal peptidyl-serine dimethylation / N-terminal peptidyl-serine trimethylation / protein N-terminal methyltransferase / N-terminal peptidyl-proline dimethylation / N-terminal protein N-methyltransferase activity / protein methyltransferase activity / spindle organization / histone methyltransferase activity / chromosome segregation ...N-terminal peptidyl-glycine methylation / N-terminal peptidyl-serine dimethylation / N-terminal peptidyl-serine trimethylation / protein N-terminal methyltransferase / N-terminal peptidyl-proline dimethylation / N-terminal protein N-methyltransferase activity / protein methyltransferase activity / spindle organization / histone methyltransferase activity / chromosome segregation / nucleoplasm / nucleus / cytosol / cytoplasm類似検索 - 分子機能 Alpha-N-methyltransferase NTM1 / AdoMet dependent proline di-methyltransferase / S-adenosyl-L-methionine-dependent methyltransferase superfamily類似検索 - ドメイン・相同性 4HP-PRO-LYS-ARG-NH2, BM-30 / S-ADENOSYL-L-HOMOCYSTEINE / N-terminal Xaa-Pro-Lys N-methyltransferase 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) synthetic construct (人工物) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.729 Å |
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データ登録者 | Noinaj, N. / Chen, D. / Huang, R. |
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資金援助 | 米国, 2件 組織 | 認可番号 | 国 |
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National Institutes of Health/National Cancer Institute (NIH/NCI) | 1U01CA214649-01 | 米国 | National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) | 1R01GM117275-01A1 | 米国 |
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引用 | ジャーナル: J.Med.Chem. / 年: 2020 タイトル: Selective Peptidomimetic Inhibitors of NTMT1/2: Rational Design, Synthesis, Characterization, and Crystallographic Studies. 著者: Mackie, B.D. / Chen, D. / Dong, G. / Dong, C. / Parker, H. / Schaner Tooley, C.E. / Noinaj, N. / Min, J. / Huang, R. |
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履歴 | 登録 | 2020年4月7日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年8月26日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2021年3月10日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year |
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改定 1.2 | 2023年10月18日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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