登録情報 データベース : PDB / ID : 6w6d 構造の表示 ダウンロードとリンクタイトル Crystal Structure of Human Protein arginine N-methyltransferase 6 (PRMT6) in complex with SGC6870 inhibitor 要素Protein arginine N-methyltransferase 6 詳細 キーワード TRANSFERASE/TRANSFERASE Inhibitor / PRMT6 and SGC6870 inhibitor / Structural Genomics / Structural Genomics Consortium / SGC / TRANSFERASE / TRANSFERASE-TRANSFERASE Inhibitor complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
histone H2AR3 methyltransferase activity / protein-arginine omega-N monomethyltransferase activity / histone H4R3 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / protein-arginine omega-N asymmetric methyltransferase activity / regulation of megakaryocyte differentiation / histone arginine N-methyltransferase activity / protein-arginine N-methyltransferase activity / regulation of mitochondrion organization ... histone H2AR3 methyltransferase activity / protein-arginine omega-N monomethyltransferase activity / histone H4R3 methyltransferase activity / histone H3R2 methyltransferase activity / type I protein arginine methyltransferase / protein-arginine omega-N asymmetric methyltransferase activity / regulation of megakaryocyte differentiation / histone arginine N-methyltransferase activity / protein-arginine N-methyltransferase activity / regulation of mitochondrion organization / histone H3 methyltransferase activity / histone methyltransferase activity / negative regulation of ubiquitin-dependent protein catabolic process / regulation of signal transduction by p53 class mediator / RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function / protein modification process / base-excision repair / cellular senescence / RMTs methylate histone arginines / histone binding / methylation / chromatin remodeling / negative regulation of DNA-templated transcription / chromatin binding / nucleolus / negative regulation of transcription by RNA polymerase II / nucleoplasm / nucleus 類似検索 - 分子機能 Hnrnp arginine n-methyltransferase1 / Hnrnp arginine n-methyltransferase1 / Methyltransferase domain 25 / Methyltransferase domain / Protein arginine N-methyltransferase / SAM-dependent methyltransferase PRMT-type domain profile. / Distorted Sandwich / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Mainly Beta 類似検索 - ドメイン・相同性 S-ADENOSYL-L-HOMOCYSTEINE / Chem-T9A / Protein arginine N-methyltransferase 6 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / フーリエ合成 / 解像度 : 1.91 Å 詳細データ登録者 Halabelian, L. / Zeng, H. / Dong, A. / Jin, J. / Shen, Y. / Kaniskan, H.U. / Hutchinson, A. / Seitova, A. / Bountra, C. / Edwards, A.M. ...Halabelian, L. / Zeng, H. / Dong, A. / Jin, J. / Shen, Y. / Kaniskan, H.U. / Hutchinson, A. / Seitova, A. / Bountra, C. / Edwards, A.M. / Arrowsmith, C.H. / Brown, P.J. / Structural Genomics Consortium (SGC) 引用ジャーナル : J.Med.Chem. / 年 : 2021タイトル : A First-in-Class, Highly Selective and Cell-Active Allosteric Inhibitor of Protein Arginine Methyltransferase 6.著者: Shen, Y. / Li, F. / Szewczyk, M.M. / Halabelian, L. / Chau, I. / Eram, M.S. / Dela Sena, C. / Park, K.S. / Meng, F. / Chen, H. / Zeng, H. / Dong, A. / Wu, H. / Trush, V.V. / McLeod, D. / ... 著者 : Shen, Y. / Li, F. / Szewczyk, M.M. / Halabelian, L. / Chau, I. / Eram, M.S. / Dela Sena, C. / Park, K.S. / Meng, F. / Chen, H. / Zeng, H. / Dong, A. / Wu, H. / Trush, V.V. / McLeod, D. / Zepeda-Velazquez, C.A. / Campbell, R.M. / Mader, M.M. / Watson, B.M. / Schapira, M. / Arrowsmith, C.H. / Al-Awar, R. / Barsyte-Lovejoy, D. / Kaniskan, H.U. / Brown, P.J. / Vedadi, M. / Jin, J. 履歴 登録 2020年3月16日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2020年4月29日 Provider : repository / タイプ : Initial release改定 1.1 2022年2月23日 Group : Database references / カテゴリ : citation / citation_author / database_2Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession 改定 1.2 2023年10月18日 Group : Data collection / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond / pdbx_initial_refinement_model
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