- PDB-6w3j: Crystal structure of the FAM46C/Plk4/Cep192 complex -
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基本情報
登録情報
データベース: PDB / ID: 6w3j
タイトル
Crystal structure of the FAM46C/Plk4/Cep192 complex
要素
Centrosomal protein of 192 kDa
Serine/threonine-protein kinase PLK4
Terminal nucleotidyltransferase 5C
キーワード
TRANSFERASE / RNA polymerase
機能・相同性
機能・相同性情報
centrosome-templated microtubule nucleation / de novo centriole assembly involved in multi-ciliated epithelial cell differentiation / procentriole / deuterosome / procentriole replication complex / positive regulation of centriole replication / trophoblast giant cell differentiation / centriole replication / polo kinase / XY body ...centrosome-templated microtubule nucleation / de novo centriole assembly involved in multi-ciliated epithelial cell differentiation / procentriole / deuterosome / procentriole replication complex / positive regulation of centriole replication / trophoblast giant cell differentiation / centriole replication / polo kinase / XY body / poly(A) RNA polymerase activity / polynucleotide adenylyltransferase / mRNA stabilization / protein localization to centrosome / pericentriolar material / cleavage furrow / negative regulation of cell differentiation / mitotic spindle assembly / cilium assembly / phosphatase binding / Loss of Nlp from mitotic centrosomes / Loss of proteins required for interphase microtubule organization from the centrosome / Recruitment of mitotic centrosome proteins and complexes / Recruitment of NuMA to mitotic centrosomes / Anchoring of the basal body to the plasma membrane / centriole / AURKA Activation by TPX2 / response to bacterium / Regulation of PLK1 Activity at G2/M Transition / in utero embryonic development / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / centrosome / nucleolus / protein kinase binding / RNA binding / nucleoplasm / ATP binding / identical protein binding / nucleus / cytoplasm / cytosol 類似検索 - 分子機能
Centrosomal protein Spd-2/CEP192 / Terminal nucleotidyltransferase / Domain of unknown function (DUF1693) / Nucleotidyltransferase / Serine/threonine-protein kinase, first cryptic polo-box domain superfamily / : / Cryptic Polo-Box 1 (CPB1) domain profile. / Cryptic Polo-Box 2 (CPB2) domain profile. / Plk4, C-terminal polo-box domain / Plk4, second cryptic polo-box domain ...Centrosomal protein Spd-2/CEP192 / Terminal nucleotidyltransferase / Domain of unknown function (DUF1693) / Nucleotidyltransferase / Serine/threonine-protein kinase, first cryptic polo-box domain superfamily / : / Cryptic Polo-Box 1 (CPB1) domain profile. / Cryptic Polo-Box 2 (CPB2) domain profile. / Plk4, C-terminal polo-box domain / Plk4, second cryptic polo-box domain / Plk4, first cryptic polo-box domain / Polo-like Kinase 4 Polo Box 1 / Polo-like Kinase 4 Polo Box 2 / POLO box domain / POLO box domain profile. / Tyrosine-protein kinase, active site / Protein kinase domain / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Immunoglobulin-like fold / Protein kinase-like domain superfamily 類似検索 - ドメイン・相同性
Serine/threonine-protein kinase PLK4 / Terminal nucleotidyltransferase 5C / Centrosomal protein of 192 kDa 類似検索 - 構成要素