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- PDB-6vma: T4H2 T cell receptor bound to HLA-A2 presenting gp100 peptide (IT... -

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Basic information

Entry
Database: PDB / ID: 6vma
TitleT4H2 T cell receptor bound to HLA-A2 presenting gp100 peptide (ITDQVPFSV)
Components
  • (T4H2 T cell receptor ...) x 2
  • Beta-2-microglobulin
  • MHC class I antigen, A-2 alpha chain
  • Melanocyte protein PMEL
KeywordsIMMUNE SYSTEM / TCR / MHC class I / HLA A2 / melanoma
Function / homology
Function and homology information


cis-Golgi network membrane / positive regulation of melanin biosynthetic process / melanin biosynthetic process / melanosome membrane / melanosome organization / multivesicular body, internal vesicle / multivesicular body membrane / Regulation of MITF-M-dependent genes involved in pigmentation / antigen processing and presentation of peptide antigen via MHC class I / negative regulation of receptor binding ...cis-Golgi network membrane / positive regulation of melanin biosynthetic process / melanin biosynthetic process / melanosome membrane / melanosome organization / multivesicular body, internal vesicle / multivesicular body membrane / Regulation of MITF-M-dependent genes involved in pigmentation / antigen processing and presentation of peptide antigen via MHC class I / negative regulation of receptor binding / early endosome lumen / Nef mediated downregulation of MHC class I complex cell surface expression / DAP12 interactions / transferrin transport / cellular response to iron ion / Endosomal/Vacuolar pathway / lumenal side of endoplasmic reticulum membrane / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / peptide antigen assembly with MHC class II protein complex / cellular response to iron(III) ion / MHC class II protein complex / negative regulation of forebrain neuron differentiation / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / ER to Golgi transport vesicle membrane / peptide antigen assembly with MHC class I protein complex / regulation of iron ion transport / regulation of erythrocyte differentiation / HFE-transferrin receptor complex / response to molecule of bacterial origin / MHC class I peptide loading complex / T cell mediated cytotoxicity / positive regulation of T cell cytokine production / antigen processing and presentation of endogenous peptide antigen via MHC class I / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response / MHC class I protein complex / positive regulation of T cell activation / peptide antigen binding / positive regulation of receptor-mediated endocytosis / negative regulation of neurogenesis / cellular response to nicotine / positive regulation of T cell mediated cytotoxicity / multicellular organismal-level iron ion homeostasis / specific granule lumen / phagocytic vesicle membrane / recycling endosome membrane / Interferon gamma signaling / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / negative regulation of epithelial cell proliferation / MHC class II protein complex binding / Modulation by Mtb of host immune system / late endosome membrane / sensory perception of smell / positive regulation of cellular senescence / tertiary granule lumen / melanosome / DAP12 signaling / T cell differentiation in thymus / negative regulation of neuron projection development / ER-Phagosome pathway / protein refolding / early endosome membrane / protein homotetramerization / amyloid fibril formation / intracellular iron ion homeostasis / learning or memory / immune response / endoplasmic reticulum lumen / Amyloid fiber formation / Golgi membrane / lysosomal membrane / external side of plasma membrane / focal adhesion / Neutrophil degranulation / endoplasmic reticulum membrane / SARS-CoV-2 activates/modulates innate and adaptive immune responses / structural molecule activity / cell surface / endoplasmic reticulum / Golgi apparatus / protein homodimerization activity / extracellular space / extracellular exosome / extracellular region / identical protein binding / membrane / plasma membrane / cytosol
Similarity search - Function
PKD- and KLD-Associated Transmembrane / PKAT, KLD domain / PKAT, KLD domain / PKD domain / Polycystic kidney disease (PKD) domain profile. / PKD domain / PKD domain superfamily / PKD/Chitinase domain / Repeats in polycystic kidney disease 1 (PKD1) and other proteins / MHC class I, alpha chain, C-terminal ...PKD- and KLD-Associated Transmembrane / PKAT, KLD domain / PKAT, KLD domain / PKD domain / Polycystic kidney disease (PKD) domain profile. / PKD domain / PKD domain superfamily / PKD/Chitinase domain / Repeats in polycystic kidney disease 1 (PKD1) and other proteins / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Beta-2-Microglobulin / : / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / MHC classes I/II-like antigen recognition protein / : / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold
Similarity search - Domain/homology
Major histocompatibility complex, class I, A / MHC class I antigen / Melanocyte protein PMEL / Beta-2-microglobulin
Similarity search - Component
Biological speciesHomo sapiens (human)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.75 Å
AuthorsSmith, A.R. / Baker, B.M.
Funding support1items
OrganizationGrant numberCountry
National Institutes of Health/National Cancer Institute (NIH/NCI)
CitationJournal: Proc.Natl.Acad.Sci.USA / Year: 2021
Title: Structurally silent peptide anchor modifications allosterically modulate T cell recognition in a receptor-dependent manner
Authors: Smith, A.R. / Alonso, J.A. / Ayres, C.M. / Singh, N.K. / Hellman, L.M. / Baker, B.M.
History
DepositionJan 27, 2020Deposition site: RCSB / Processing site: RCSB
Revision 1.0Jan 20, 2021Provider: repository / Type: Initial release
Revision 1.1Jan 27, 2021Group: Database references / Category: citation / citation_author
Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.pdbx_database_id_DOI / _citation.title / _citation.year
Revision 1.2Oct 11, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Revision 1.3Oct 30, 2024Group: Structure summary / Category: pdbx_entry_details / pdbx_modification_feature

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: MHC class I antigen, A-2 alpha chain
B: Beta-2-microglobulin
D: T4H2 T cell receptor alpha chain
E: T4H2 T cell receptor beta chain
C: Melanocyte protein PMEL


Theoretical massNumber of molelcules
Total (without water)94,9355
Polymers94,9355
Non-polymers00
Water66737
1
A: MHC class I antigen, A-2 alpha chain
B: Beta-2-microglobulin
C: Melanocyte protein PMEL

D: T4H2 T cell receptor alpha chain
E: T4H2 T cell receptor beta chain


Theoretical massNumber of molelcules
Total (without water)94,9355
Polymers94,9355
Non-polymers00
Water724
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
crystal symmetry operation4_655-x+1,-y,z1
Buried area10210 Å2
ΔGint-58 kcal/mol
Surface area38950 Å2
MethodPISA
Unit cell
Length a, b, c (Å)129.934, 129.934, 115.412
Angle α, β, γ (deg.)90.000, 90.000, 120.000
Int Tables number172
Space group name H-MP64
Space group name HallP64
Symmetry operation#1: x,y,z
#2: x-y,x,z+2/3
#3: y,-x+y,z+1/3
#4: -y,x-y,z+1/3
#5: -x+y,-x,z+2/3
#6: -x,-y,z

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Components

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Protein , 2 types, 2 molecules AB

#1: Protein MHC class I antigen, A-2 alpha chain


Mass: 31854.203 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: HLA-A / Plasmid: pHN1 / Production host: Escherichia coli (E. coli) / Strain (production host): XL1-Blue / References: UniProt: A0A5B8RNS7, UniProt: A0A140T913*PLUS
#2: Protein Beta-2-microglobulin


Mass: 11879.356 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: B2M, CDABP0092, HDCMA22P / Plasmid: pHN1 / Production host: Escherichia coli (E. coli) / Strain (production host): XL1-Blue / References: UniProt: P61769

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T4H2 T cell receptor ... , 2 types, 2 molecules DE

#3: Protein T4H2 T cell receptor alpha chain


Mass: 22768.986 Da / Num. of mol.: 1 / Mutation: 0
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TRAV12-2, TRAC / Plasmid: pGMT7 / Production host: Escherichia coli BL21(DE3) (bacteria) / Variant (production host): pLysS
#4: Protein T4H2 T cell receptor beta chain


Mass: 27427.480 Da / Num. of mol.: 1 / Mutation: 0
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: TRBV19, TRBC2 / Plasmid: pGMT7 / Production host: Escherichia coli BL21(DE3) (bacteria) / Variant (production host): pLysS

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Protein/peptide / Non-polymers , 2 types, 38 molecules C

#5: Protein/peptide Melanocyte protein PMEL / ME20-M / ME20M / Melanocyte protein Pmel 17 / Melanocytes lineage-specific antigen GP100 / Melanoma- ...ME20-M / ME20M / Melanocyte protein Pmel 17 / Melanocytes lineage-specific antigen GP100 / Melanoma-associated ME20 antigen / P1 / P100 / Premelanosome protein / Silver locus protein homolog


Mass: 1005.121 Da / Num. of mol.: 1 / Fragment: epitope (UNP residues 209-217) / Source method: obtained synthetically / Source: (synth.) Homo sapiens (human) / References: UniProt: P40967
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 37 / Source method: isolated from a natural source / Formula: H2O

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Details

Has protein modificationY

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.96 Å3/Da / Density % sol: 58.48 %
Crystal growTemperature: 296 K / Method: vapor diffusion, hanging drop / pH: 8.5
Details: 18% v/v PEG10000, 16% v/v glycerol, 100 mM Tris pH 8.5, 100 mM sodium chloride

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: APS / Beamline: 22-ID / Wavelength: 1 Å
DetectorType: DECTRIS EIGER X 16M / Detector: PIXEL / Date: Mar 24, 2018
RadiationMonochromator: Si(111) / Protocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 1 Å / Relative weight: 1
ReflectionResolution: 2.75→20 Å / Num. obs: 28619 / % possible obs: 100 % / Redundancy: 9.8 % / Biso Wilson estimate: 48.46 Å2 / CC1/2: 1 / CC star: 1 / Rmerge(I) obs: 0.07 / Rpim(I) all: 0.024 / Rrim(I) all: 0.074 / Χ2: 0.967 / Net I/σ(I): 32.3
Reflection shellResolution: 2.75→2.8 Å / Redundancy: 9.6 % / Rmerge(I) obs: 1.334 / Mean I/σ(I) obs: 1.8 / Num. unique obs: 1407 / CC1/2: 0.632 / CC star: 0.88 / Rpim(I) all: 0.452 / Rrim(I) all: 1.409 / Χ2: 0.882 / % possible all: 100

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Processing

Software
NameVersionClassification
PHENIX1.13_2998refinement
PHENIX1.13_2998refinement
HKL-2000data reduction
HKL-2000data scaling
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: PDB entry 1TVH

1tvh


Resolution: 2.75→19.95 Å / SU ML: 0.3425 / Cross valid method: FREE R-VALUE / σ(F): 1.36 / Phase error: 22.3337
RfactorNum. reflection% reflection
Rfree0.2192 1983 7.05 %
Rwork0.1765 --
obs0.1795 28122 98.3 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso mean: 59.66 Å2
Refinement stepCycle: LAST / Resolution: 2.75→19.95 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms6633 0 0 37 6670
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.0036816
X-RAY DIFFRACTIONf_angle_d0.56049260
X-RAY DIFFRACTIONf_chiral_restr0.0433964
X-RAY DIFFRACTIONf_plane_restr0.00391216
X-RAY DIFFRACTIONf_dihedral_angle_d20.75472504
LS refinement shell
Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection RworkRefine-ID% reflection obs (%)
2.75-2.820.33781130.26481510X-RAY DIFFRACTION79.68
2.82-2.90.30031380.25271831X-RAY DIFFRACTION97.38
2.9-2.980.29471450.23971872X-RAY DIFFRACTION99.7
2.98-3.080.29031430.23231892X-RAY DIFFRACTION100
3.08-3.190.23441430.21991894X-RAY DIFFRACTION100
3.19-3.320.29381530.21231884X-RAY DIFFRACTION100
3.32-3.470.23751440.18771902X-RAY DIFFRACTION100
3.47-3.650.22111450.1881875X-RAY DIFFRACTION100
3.65-3.880.21741390.17861908X-RAY DIFFRACTION99.9
3.88-4.170.21331460.16491903X-RAY DIFFRACTION100
4.17-4.590.19281460.14221915X-RAY DIFFRACTION100
4.59-5.240.16541430.13461895X-RAY DIFFRACTION99.95
5.24-6.560.18561410.16071913X-RAY DIFFRACTION99.95
6.56-19.950.18371440.14721945X-RAY DIFFRACTION99.71
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
12.30194118565-0.0248897795927-0.03416474460383.580858091210.3159548717971.49125745673-0.158118485138-0.307756080744-0.04762599019310.4027920360090.007215034755050.0304198589250.1181678178560.2795819419220.1295867491410.27063318304-0.09259620168850.0312013187150.5736627902890.172986263850.26330178552331.4275343667-1.4271368639-1.88191851345
26.617947268013.4763893049-1.557437471184.01914102982-0.5317225778582.43904742515-0.4569026902090.8391494938280.50628474029-0.6706384580480.3433954261080.8895196215190.1469362830410.1446110082130.09067302513870.301378007446-0.099041520804-0.09492299001950.3848256669030.13484999350.39746345211318.32481229571.06912280855-18.1275117637
32.366862429710.811690567073-0.3428077235851.001798829770.03382759956382.42980939963-0.283710084662-0.366161949853-0.7471408628080.2335331452630.07633017951820.4806684150610.436825101904-0.4139525893760.1373108841750.334850858003-0.1383227140310.1584356992760.5322248620440.1256554938010.911309105057-2.46352786156-17.2651788952-4.05545385083
43.40154981697-0.824287264424-0.3699099504034.28664070134-1.536375394591.90047843568-0.0856623165648-0.357072671451-0.847610978462-0.1091634655810.04518772708780.723009841199-0.117401306286-0.265759683811-0.285570189020.449382743417-0.1190620036320.2230047739530.3641544526910.1707452836120.574695913715.3838420997-23.1551022702-4.08330304307
53.179364256790.5100702178340.9810133391554.922863392570.4361883858372.72723603129-0.0499416443975-0.129405372593-0.982549030266-0.0430206884866-0.108040416048-0.05137886264320.2985989854170.3344429327230.1230023083460.346415406350.007895993156130.1793932382420.471818017360.2367477048920.56822058534222.6994806466-22.7627233502-5.0103465429
64.078756472853.79919954435-1.378799312625.551406180970.920513515332.881530490550.711324818989-0.509719820908-1.37073286491-0.802245732162-0.08603031025361.144030544111.40254449612-0.634475535164-0.4658274584591.26512709281-0.0590811990161-0.07911961447960.5429604070730.0008925825571181.4929657571110.9639084047-39.4852869735-11.3735050322
73.476554730861.617572139721.534696969734.868780085150.9837311791234.870968803290.0563396526867-0.359305775369-0.7720776535190.658481055468-0.1066679104620.7939020496350.680993372140.1727250689340.04966926023860.598623731668-0.01474732815620.1744890642090.4487540059890.2626590337180.80063417710617.4682104662-29.86350582581.10238813789
84.15930613346-1.19926357651.37899627523.11893105672-0.5293656677332.61798033191-0.2159231863240.460920968584-0.977519116077-2.439248383140.5520764215320.3821134758320.76454872496-0.207803752225-0.4165395679120.8082317884-0.1527446992190.03409517609910.595059497677-0.2332014759770.77443055354186.4382858775-30.2736314418-19.9764157242
95.32538432437-0.8314019325570.9611241375734.46377173592-0.4350915933392.92406806371-0.1255441538-0.666757081236-0.844653065822-0.2880605058330.328802942527-0.2632850963150.346799333657-0.00494338049178-0.1748146613080.365591425037-0.1543274153540.06249547337340.551554917549-0.105164531780.41673732677690.1351298349-23.7207935285-10.5323331346
108.454542604622.447758269780.4614223376992.19694511475-1.825573611754.90134390125-0.2004296148340.097859557576-1.57415226082-0.5304345003120.7028275698770.4118169915180.540977805119-0.751666092415-0.2437586009480.57130772579-0.1304493597940.1972014491980.598221397144-0.07114235195240.91554141552688.3681154721-33.3147577202-10.6221967948
112.24035490907-0.6333149824711.114413232420.199629264203-0.2269365066040.942813118176-0.09093848420640.0222676779419-0.0455950897962-0.3194401092910.09397170214130.4907818506580.0490726120366-0.0419069330165-0.426206905940.353789493863-0.2437297740450.05410073866530.50328410133-0.1482427455910.33071635105286.5212390565-16.1840795403-15.2465057012
123.33335152263.934616340090.7366877558844.656118292880.9803743025611.236679345690.003089910995480.52335791155-1.0922427466-0.1583905248760.0375134227123-0.817707005610.6337066318250.611550172663-0.1314494486810.921454631231-0.156320688509-0.08392946069950.444561945691-0.09686228724431.1011471895978.2786139024-47.0906458087-15.6675525364
130.3446797216820.873045668023-1.336576913457.66219311226-1.217486131226.048631929980.4905526255210.243369527888-0.709418027676-0.1595777266990.1081219122360.6124506184960.963630611337-0.8290082388191.211285172981.13705654459-0.373538221781-0.1052794616810.616790921971-0.2296646572470.74971929921154.8942831052-50.446389617-19.8983589741
145.60741682046-2.45729426123-0.6696982482997.83066330772-0.5723350653982.540035475910.3521177399430.854292651650.0891902842189-1.41229638992-0.150286773307-0.8144849242950.2012235012530.366752845069-0.2734957820421.12896000527-0.2851732377750.210523564190.887804910541-0.1846437760010.89685998537269.1541321942-45.2533772866-27.1246981755
156.1799641684-1.635620531641.766747743367.552621697560.2116313828534.72481490635-0.3436026498270.0702485009838-0.3816559636610.120660134080.410722040007-0.9217560162070.3227575878560.338134026408-0.230049754570.859479205323-0.1181796443770.02246624441640.36930282428-0.2213826082320.68537570410967.1817134862-46.0736481851-15.4169039891
161.890930141560.130693662517-2.332723602266.899228406550.1305150036252.88979439201-0.07032016132291.44414367724-0.912439303217-1.347396528330.2487785944090.5908731558920.1756236942980.09912655075950.4518694903011.64805782259-0.180371296273-0.2713340314371.05138646456-0.520773660721.0074769711455.1332028005-49.0933563555-30.8751321507
176.06499649941-3.08519756381.688128584676.717884710731.264185340642.105470760230.1872465626191.39179240723-0.936403280044-2.24213520481-0.357511260176-0.3210636811160.7771155597180.1140529825550.07144824893811.52505425958-0.1681541675130.1330072188560.937338645719-0.2025681465290.830454963767.6634097277-55.1341282055-27.7944796654
183.95343219398-0.228910788238-0.6177481113082.22472475393-0.00238211843880.565399205371-0.0776822746465-0.231630751550.116676185083-0.1274427152680.2919752880.25220917009-0.0270660570259-0.225380918795-0.1319697913820.272600916388-0.2102380468530.08571997745150.789490966073-0.04872497763430.39793666645471.5500009402-9.22414820357-13.256652075
195.566626143193.38234775089-1.235783698545.580932606250.2949357264950.584372948685-0.2608419515540.7081157687020.742506815788-0.2817887227370.559173046361.0124664034-0.5336086887760.432796918462-0.1691029176090.363524372786-0.2653148204160.004767757232510.7614451886210.1564862217530.51858823899754.4359291613-20.3177141246-21.5430897314
202.34591703209-0.74451399216-0.6003447176772.399133959580.1106307947992.828853995270.1255950120930.0822028149459-0.353690107444-0.3174738971440.0963209293435-0.4115576034440.461799740531-0.29875974411-0.111875811010.498166426406-0.210844852998-0.06529489509350.346592536254-0.05771083339730.45905712850658.9113938207-39.8009831247-15.1184780174
213.34270564859-0.329131511209-0.573987854943.76331540291-0.278365566932.213409268070.228336377015-0.046628141856-0.3141510967680.08061306508080.10585164341-0.0465751663330.357417339299-0.588041192815-0.3317637453730.362915867188-0.23042281238-0.02845081860020.5100281547540.05746867338030.3706972061251.7633928567-36.6646535377-9.72189977827
221.195872413211.34456934806-0.905093587487.822260099992.777347251172.965767630210.0141410953241-0.500088142415-0.1292413993880.8087688899360.1502842045570.07747487557580.2147533962420.2838012193430.2283550393440.239098261546-0.009902918451170.01990384182020.6382671844680.2219075999870.28073050772936.4273615343.97411470971-3.02393262019
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection details
1X-RAY DIFFRACTION1chain 'A' and (resid 1 through 162 )
2X-RAY DIFFRACTION2chain 'A' and (resid 163 through 185 )
3X-RAY DIFFRACTION3chain 'A' and (resid 186 through 275 )
4X-RAY DIFFRACTION4chain 'B' and (resid 1 through 20 )
5X-RAY DIFFRACTION5chain 'B' and (resid 21 through 72 )
6X-RAY DIFFRACTION6chain 'B' and (resid 73 through 78 )
7X-RAY DIFFRACTION7chain 'B' and (resid 79 through 100 )
8X-RAY DIFFRACTION8chain 'D' and (resid 2 through 19 )
9X-RAY DIFFRACTION9chain 'D' and (resid 20 through 70 )
10X-RAY DIFFRACTION10chain 'D' and (resid 71 through 85 )
11X-RAY DIFFRACTION11chain 'D' and (resid 86 through 105 )
12X-RAY DIFFRACTION12chain 'D' and (resid 106 through 119 )
13X-RAY DIFFRACTION13chain 'D' and (resid 120 through 138 )
14X-RAY DIFFRACTION14chain 'D' and (resid 139 through 153 )
15X-RAY DIFFRACTION15chain 'D' and (resid 154 through 178 )
16X-RAY DIFFRACTION16chain 'D' and (resid 179 through 188 )
17X-RAY DIFFRACTION17chain 'D' and (resid 189 through 202 )
18X-RAY DIFFRACTION18chain 'E' and (resid 2 through 105 )
19X-RAY DIFFRACTION19chain 'E' and (resid 106 through 120 )
20X-RAY DIFFRACTION20chain 'E' and (resid 121 through 186 )
21X-RAY DIFFRACTION21chain 'E' and (resid 187 through 240 )
22X-RAY DIFFRACTION22chain 'C' and (resid 1 through 9 )

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