登録情報 | データベース: PDB / ID: 6v9s |
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タイトル | Structure-based development of subtype-selective orexin 1 receptor antagonists |
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要素 | Orexin receptor type 1,GlgA glycogen synthase chimera |
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キーワード | SIGNALING PROTEIN / GPCR / orexin receptor / selective ligand |
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機能・相同性 | 機能・相同性情報
orexin receptor activity / Orexin and neuropeptides FF and QRFP bind to their respective receptors / alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity / feeding behavior / peptide hormone binding / regulation of cytosolic calcium ion concentration / neuropeptide signaling pathway / cellular response to hormone stimulus / G protein-coupled receptor activity / chemical synaptic transmission ...orexin receptor activity / Orexin and neuropeptides FF and QRFP bind to their respective receptors / alpha-1,4-glucan glucosyltransferase (UDP-glucose donor) activity / feeding behavior / peptide hormone binding / regulation of cytosolic calcium ion concentration / neuropeptide signaling pathway / cellular response to hormone stimulus / G protein-coupled receptor activity / chemical synaptic transmission / G alpha (q) signalling events / positive regulation of ERK1 and ERK2 cascade / synapse / plasma membrane類似検索 - 分子機能 Orexin/Hypocretin receptor type 1 / Orexin receptor family / Glycosyl transferases group 1 / Bacterial/plant glycogen synthase / Starch synthase, catalytic domain / Starch synthase catalytic domain / Glycosyl transferases group 1 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like ...Orexin/Hypocretin receptor type 1 / Orexin receptor family / Glycosyl transferases group 1 / Bacterial/plant glycogen synthase / Starch synthase, catalytic domain / Starch synthase catalytic domain / Glycosyl transferases group 1 / Serpentine type 7TM GPCR chemoreceptor Srsx / G-protein coupled receptors family 1 signature. / G protein-coupled receptor, rhodopsin-like / GPCR, rhodopsin-like, 7TM / G-protein coupled receptors family 1 profile. / 7 transmembrane receptor (rhodopsin family)類似検索 - ドメイン・相同性 CHOLESTEROL / Chem-JHC / OLEIC ACID / Orexin/Hypocretin receptor type 1 / Glycogen synthase類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
 Pyrococcus abyssi (古細菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.5 Å |
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データ登録者 | Hellmann, J. / Drabek, M. / Yin, J. / Huebner, H. / Kraus, F. / Proell, T. / Weikert, D. / Kolb, P. / Rosenbaum, D.M. / Gmeiner, P. |
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資金援助 | 米国, 1件 組織 | 認可番号 | 国 |
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Welch Foundation | I-1770 | 米国 |
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引用 | ジャーナル: Proc.Natl.Acad.Sci.USA / 年: 2020 タイトル: Structure-based development of a subtype-selective orexin 1 receptor antagonist. 著者: Hellmann, J. / Drabek, M. / Yin, J. / Gunera, J. / Proll, T. / Kraus, F. / Langmead, C.J. / Hubner, H. / Weikert, D. / Kolb, P. / Rosenbaum, D.M. / Gmeiner, P. |
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履歴 | 登録 | 2019年12月16日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年7月15日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年7月29日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed ..._citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2020年8月12日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.3 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.4 | 2024年11月13日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature Item: _pdbx_entry_details.has_protein_modification |
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