+Open data
-Basic information
Entry | Database: PDB / ID: 6ux9 | ||||||
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Title | Crystal Structure Analysis of PIP4K2A | ||||||
Components | Phosphatidylinositol 5-phosphate 4-kinase type-2 alpha | ||||||
Keywords | TRANSFERASE / kinase / SIGNALING PROTEIN | ||||||
Function / homology | Function and homology information vesicle-mediated cholesterol transport / 1-phosphatidylinositol-5-phosphate 4-kinase / 1-phosphatidylinositol-5-phosphate 4-kinase activity / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process / Synthesis of PIPs in the nucleus / 1-phosphatidylinositol-4-phosphate 5-kinase activity / autophagosome-lysosome fusion / positive regulation of autophagosome assembly / megakaryocyte development / PI5P Regulates TP53 Acetylation ...vesicle-mediated cholesterol transport / 1-phosphatidylinositol-5-phosphate 4-kinase / 1-phosphatidylinositol-5-phosphate 4-kinase activity / 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process / Synthesis of PIPs in the nucleus / 1-phosphatidylinositol-4-phosphate 5-kinase activity / autophagosome-lysosome fusion / positive regulation of autophagosome assembly / megakaryocyte development / PI5P Regulates TP53 Acetylation / Synthesis of PIPs at the plasma membrane / phosphatidylinositol phosphate biosynthetic process / photoreceptor outer segment / autophagosome / negative regulation of insulin receptor signaling pathway / photoreceptor inner segment / regulation of autophagy / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / lysosome / phosphorylation / protein homodimerization activity / nucleoplasm / ATP binding / plasma membrane / cytosol Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.71 Å | ||||||
Authors | Seo, H.-S. / Dhe-Paganon, S. | ||||||
Funding support | United States, 1items
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Citation | Journal: J.Med.Chem. / Year: 2020 Title: Discovery and Structure-Activity Relationship Study of ( Z )-5-Methylenethiazolidin-4-one Derivatives as Potent and Selective Pan-phosphatidylinositol 5-Phosphate 4-Kinase Inhibitors. Authors: Manz, T.D. / Sivakumaren, S.C. / Ferguson, F.M. / Zhang, T. / Yasgar, A. / Seo, H.S. / Ficarro, S.B. / Card, J.D. / Shim, H. / Miduturu, C.V. / Simeonov, A. / Shen, M. / Marto, J.A. / Dhe- ...Authors: Manz, T.D. / Sivakumaren, S.C. / Ferguson, F.M. / Zhang, T. / Yasgar, A. / Seo, H.S. / Ficarro, S.B. / Card, J.D. / Shim, H. / Miduturu, C.V. / Simeonov, A. / Shen, M. / Marto, J.A. / Dhe-Paganon, S. / Hall, M.D. / Cantley, L.C. / Gray, N.S. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6ux9.cif.gz | 290.2 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6ux9.ent.gz | 232.5 KB | Display | PDB format |
PDBx/mmJSON format | 6ux9.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6ux9_validation.pdf.gz | 392.6 KB | Display | wwPDB validaton report |
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Full document | 6ux9_full_validation.pdf.gz | 397.4 KB | Display | |
Data in XML | 6ux9_validation.xml.gz | 2.6 KB | Display | |
Data in CIF | 6ux9_validation.cif.gz | 11.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ux/6ux9 ftp://data.pdbj.org/pub/pdb/validation_reports/ux/6ux9 | HTTPS FTP |
-Related structure data
Related structure data | 6ospS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
Deposited unit |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Ens-ID: 1
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