登録情報 | データベース: PDB / ID: 6um8 |
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タイトル | HIV Integrase in complex with Compound-14 |
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要素 | Integrase |
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キーワード | TRANSFERASE / Hydrolase / DNA Integration / AIDS / RNASEH / LEDGF / ENDONUCLEASE / HIV-1 integrase |
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機能・相同性 | 機能・相同性情報
RNA-directed DNA polymerase activity / HIV-1 retropepsin / telomerase activity / symbiont-mediated activation of host apoptosis / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA ...RNA-directed DNA polymerase activity / HIV-1 retropepsin / telomerase activity / symbiont-mediated activation of host apoptosis / retroviral ribonuclease H / exoribonuclease H / exoribonuclease H activity / host multivesicular body / DNA integration / viral genome integration into host DNA / RNA-directed DNA polymerase / establishment of integrated proviral latency / viral penetration into host nucleus / RNA stem-loop binding / RNA-DNA hybrid ribonuclease activity / 転移酵素; リンを含む基を移すもの; 核酸を移すもの / host cell / viral nucleocapsid / endonuclease activity / DNA recombination / DNA-directed DNA polymerase / aspartic-type endopeptidase activity / 加水分解酵素; エステル加水分解酵素 / DNA-directed DNA polymerase activity / symbiont-mediated suppression of host gene expression / symbiont entry into host cell / viral translational frameshifting / lipid binding / host cell nucleus / host cell plasma membrane / virion membrane / structural molecule activity / proteolysis / DNA binding / zinc ion binding / membrane類似検索 - 分子機能 Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral ...Ribonuclease H-like superfamily/Ribonuclease H / Reverse transcriptase connection / Reverse transcriptase connection domain / Reverse transcriptase thumb / Reverse transcriptase thumb domain / Integrase Zinc binding domain / Zinc finger integrase-type profile. / Integrase-like, N-terminal / Integrase DNA binding domain / Integrase, C-terminal domain superfamily, retroviral / Integrase, N-terminal zinc-binding domain / Integrase, C-terminal, retroviral / Integrase DNA binding domain profile. / Immunodeficiency lentiviral matrix, N-terminal / gag gene protein p17 (matrix protein) / RNase H / Integrase core domain / Integrase, catalytic core / Integrase catalytic domain profile. / Retropepsin-like catalytic domain / Matrix protein, lentiviral and alpha-retroviral, N-terminal / Retroviral nucleocapsid Gag protein p24, C-terminal domain / Gag protein p24 C-terminal domain / RNase H type-1 domain profile. / Ribonuclease H domain / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Reverse transcriptase domain / Reverse transcriptase (RNA-dependent DNA polymerase) / Reverse transcriptase (RT) catalytic domain profile. / Retrovirus capsid, C-terminal / Retroviral matrix protein / Retrovirus capsid, N-terminal / zinc finger / Zinc knuckle / Zinc finger, CCHC-type superfamily / Zinc finger, CCHC-type / Zinc finger CCHC-type profile. / Nucleotidyltransferase; domain 5 / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Ribonuclease H superfamily / Ribonuclease H-like superfamily / Reverse transcriptase/Diguanylate cyclase domain / DNA/RNA polymerase superfamily / 2-Layer Sandwich / Alpha Beta類似検索 - ドメイン・相同性 DI(HYDROXYETHYL)ETHER / Chem-QCG / Gag-Pol polyprotein / Integrase類似検索 - 構成要素 |
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生物種 |  Human immunodeficiency virus 1 (ヒト免疫不全ウイルス) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.33 Å |
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データ登録者 | Khan, J.A. / Kish, K. |
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引用 | ジャーナル: J.Med.Chem. / 年: 2020 タイトル: Discovery and Optimization of Novel Pyrazolopyrimidines as Potent and Orally Bioavailable Allosteric HIV-1 Integrase Inhibitors. 著者: Li, G. / Meanwell, N.A. / Krystal, M.R. / Langley, D.R. / Naidu, B.N. / Sivaprakasam, P. / Lewis, H. / Kish, K. / Khan, J.A. / Ng, A. / Trainor, G.L. / Cianci, C. / Dicker, I.B. / Walker, M.A. ...著者: Li, G. / Meanwell, N.A. / Krystal, M.R. / Langley, D.R. / Naidu, B.N. / Sivaprakasam, P. / Lewis, H. / Kish, K. / Khan, J.A. / Ng, A. / Trainor, G.L. / Cianci, C. / Dicker, I.B. / Walker, M.A. / Lin, Z. / Protack, T. / Discotto, L. / Jenkins, S. / Gerritz, S.W. / Pendri, A. |
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履歴 | 登録 | 2019年10月9日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2020年3月4日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2020年3月25日 | Group: Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2023年10月11日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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