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Yorodumi- PDB-6uju: Structure of the HIV-1 gp41 transmembrane domain and cytoplasmic ... -
+Open data
-Basic information
Entry | Database: PDB / ID: 6uju | ||||||
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Title | Structure of the HIV-1 gp41 transmembrane domain and cytoplasmic tail (LLP2) | ||||||
Components | Envelope glycoprotein GP41 | ||||||
Keywords | MEMBRANE PROTEIN / Viral protein / Transmembrane domain / Cytoplasmic tail / Lipid bilayer | ||||||
Function / homology | Function and homology information Synthesis and processing of ENV and VPU / evasion of host immune response / Alpha-defensins / Dectin-2 family / Binding and entry of HIV virion / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / host cell endosome membrane / actin filament organization ...Synthesis and processing of ENV and VPU / evasion of host immune response / Alpha-defensins / Dectin-2 family / Binding and entry of HIV virion / positive regulation of plasma membrane raft polarization / positive regulation of receptor clustering / positive regulation of establishment of T cell polarity / host cell endosome membrane / actin filament organization / Assembly Of The HIV Virion / Budding and maturation of HIV virion / clathrin-dependent endocytosis of virus by host cell / viral protein processing / symbiont entry into host cell / fusion of virus membrane with host plasma membrane / virus-mediated perturbation of host defense response / fusion of virus membrane with host endosome membrane / viral envelope / virion attachment to host cell / host cell plasma membrane / virion membrane / structural molecule activity / membrane / plasma membrane Similarity search - Function | ||||||
Biological species | Human immunodeficiency virus 1 | ||||||
Method | SOLUTION NMR / simulated annealing | ||||||
Authors | Piai, A. / Fu, Q. / Cai, Y. / Ghantous, F. / Xiao, T. / Shaik, M.M. / Peng, H. / Rits-Volloch, S. / Liu, Z. / Chen, W. ...Piai, A. / Fu, Q. / Cai, Y. / Ghantous, F. / Xiao, T. / Shaik, M.M. / Peng, H. / Rits-Volloch, S. / Liu, Z. / Chen, W. / Seaman, M.S. / Chen, B. / Chou, J.J. | ||||||
Funding support | United States, 1items
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Citation | Journal: Nat Commun / Year: 2020 Title: Structural basis of transmembrane coupling of the HIV-1 envelope glycoprotein. Authors: Piai, A. / Fu, Q. / Cai, Y. / Ghantous, F. / Xiao, T. / Shaik, M.M. / Peng, H. / Rits-Volloch, S. / Chen, W. / Seaman, M.S. / Chen, B. / Chou, J.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6uju.cif.gz | 1.3 MB | Display | PDBx/mmCIF format |
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PDB format | pdb6uju.ent.gz | 1.1 MB | Display | PDB format |
PDBx/mmJSON format | 6uju.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 6uju_validation.pdf.gz | 601 KB | Display | wwPDB validaton report |
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Full document | 6uju_full_validation.pdf.gz | 2.1 MB | Display | |
Data in XML | 6uju_validation.xml.gz | 171.8 KB | Display | |
Data in CIF | 6uju_validation.cif.gz | 209.3 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/uj/6uju ftp://data.pdbj.org/pub/pdb/validation_reports/uj/6uju | HTTPS FTP |
-Related structure data
Related structure data | 6ujvC C: citing same article (ref.) |
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Similar structure data | |
Other databases |
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-Links
-Assembly
Deposited unit |
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1 |
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NMR ensembles |
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-Components
#1: Protein | Mass: 13039.172 Da / Num. of mol.: 3 / Mutation: C764S Source method: isolated from a genetically manipulated source Source: (gene. exp.) Human immunodeficiency virus 1 / Strain: Isolate 92UG024.2 / Gene: env / Plasmid: pMM-LR6 / Production host: Escherichia coli BL21(DE3) (bacteria) / Strain (production host): BL21(DE3) / References: UniProt: A0A386YSI0, UniProt: P04578*PLUS |
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-Experimental details
-Experiment
Experiment | Method: SOLUTION NMR | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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NMR experiment |
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-Sample preparation
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