Entry Database : PDB / ID : 6ttk Structure visualization Downloads & linksTitle Crystal structure of the kelch domain of human KLHL12 in complex with DVL1 peptide ComponentsDVL1 Kelch-like protein 12 DetailsKeywords LIGASE / Cullin3 E3 ligase / Kelch / Complex / Substrate peptideFunction / homology Function and homology informationFunction Domain/homology Component
positive regulation of protein localization to presynapse / Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / skeletal muscle acetylcholine-gated channel clustering / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / neural crest formation / protein localization to microtubule / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization ... positive regulation of protein localization to presynapse / Negative regulation of TCF-dependent signaling by DVL-interacting proteins / convergent extension involved in neural plate elongation / skeletal muscle acetylcholine-gated channel clustering / planar cell polarity pathway involved in neural tube closure / cochlea morphogenesis / neural crest formation / protein localization to microtubule / non-canonical Wnt signaling pathway / positive regulation of neuron projection arborization / presynapse assembly / neural crest cell development / collateral sprouting / COPII vesicle coat / COPII vesicle coating / WNT5:FZD7-mediated leishmania damping / neurotransmitter secretion / dendritic spine morphogenesis / frizzled binding / axon extension / PCP/CE pathway / Wnt signalosome / WNT mediated activation of DVL / Disassembly of the destruction complex and recruitment of AXIN to the membrane / dendrite morphogenesis / neural tube development / Wnt signaling pathway, planar cell polarity pathway / clathrin-coated vesicle / regulation of postsynapse organization / neuromuscular junction development / regulation of synaptic vesicle exocytosis / Cul3-RING ubiquitin ligase complex / heart looping / COPII-coated ER to Golgi transport vesicle / outflow tract morphogenesis / neuronal dense core vesicle / receptor clustering / synaptic vesicle exocytosis / protein monoubiquitination / positive regulation of excitatory postsynaptic potential / social behavior / protein localization to nucleus / centriolar satellite / lateral plasma membrane / canonical Wnt signaling pathway / prepulse inhibition / endoplasmic reticulum to Golgi vesicle-mediated transport / cytoplasmic microtubule organization / negative regulation of protein phosphorylation / TCF dependent signaling in response to WNT / Degradation of DVL / RHO GTPases Activate Formins / synapse organization / axon guidance / Schaffer collateral - CA1 synapse / beta-catenin binding / Wnt signaling pathway / small GTPase binding / positive regulation of neuron projection development / regulation of protein localization / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / presynapse / growth cone / cytoplasmic vesicle / microtubule / dendritic spine / postsynaptic density / protein stabilization / intracellular signal transduction / neuron projection / positive regulation of protein phosphorylation / intracellular membrane-bounded organelle / neuronal cell body / glutamatergic synapse / synapse / regulation of DNA-templated transcription / protein kinase binding / enzyme binding / positive regulation of transcription by RNA polymerase II / identical protein binding / cytosol Similarity search - Function Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain / DIX domain profile. ... Dishevelled protein domain / Dishevelled family / Dishevelled C-terminal / Dishevelled specific domain / Segment polarity protein dishevelled (Dsh) C terminal / Dishevelled-related protein / DIX domain / DIX domain superfamily / DIX domain / DIX domain profile. / Domain present in Dishevelled and axin / Kelch-type beta propeller / Domain found in Dishevelled, Egl-10, and Pleckstrin (DEP) / DEP domain profile. / Domain found in Dishevelled, Egl-10, and Pleckstrin / DEP domain / BTB-kelch protein / BTB/Kelch-associated / BTB And C-terminal Kelch / BTB And C-terminal Kelch / Kelch / Kelch repeat type 1 / Kelch motif / Kelch-type beta propeller / BTB/POZ domain / BTB domain profile. / Broad-Complex, Tramtrack and Bric a brac / BTB/POZ domain / 6 Propeller / Neuraminidase / SKP1/BTB/POZ domain superfamily / PDZ domain / PDZ domain profile. / Domain present in PSD-95, Dlg, and ZO-1/2. / PDZ domain / PDZ superfamily / Ubiquitin-like domain superfamily / Winged helix DNA-binding domain superfamily / Winged helix-like DNA-binding domain superfamily / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.383 Å DetailsAuthors Chen, Z. / Williams, E. / Pike, A.C.W. / Strain-Damerell, C. / Wang, D. / Chalk, R. / Burgess-Brown, N. / Krojer, T. / von Delft, F. / Arrowsmith, C.H. ...Chen, Z. / Williams, E. / Pike, A.C.W. / Strain-Damerell, C. / Wang, D. / Chalk, R. / Burgess-Brown, N. / Krojer, T. / von Delft, F. / Arrowsmith, C.H. / Edwards, A.M. / Bountra, C. / Bullock, A.N. CitationJournal : Open Biology / Year : 2020Title : Identification of a PGXPP degron motif in dishevelled and structural basis for its binding to the E3 ligase KLHL12.Authors : Chen, Z. / Wasney, G.A. / Picaud, S. / Filippakopoulos, P. / Vedadi, M. / D'Angiolella, V. / Bullock, A.N. History Deposition Dec 27, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Feb 12, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Aug 26, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jan 24, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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