Entry Database : PDB / ID : 6thc Structure visualization Downloads & linksTitle Crystal structure of Mycobacterium smegmatis CoaB in complex with CTP and (4-hydroxyphenyl)(2,3,4-trihydroxyphenyl)methanone ComponentsCoenzyme A biosynthesis bifunctional protein CoaBC Details Keywords LIGASE / CoaBC / bifunctional Phosphopantothenoylcysteine decarboxylase/phosphopantothenate-cysteine ligase / phosphopantothenate-cysteine ligase / Phosphopantothenoylcysteine decarboxylase / phosphopantothenoylcysteine synthetaseFunction / homology Function and homology informationFunction Domain/homology Component
pantothenate catabolic process / phosphopantothenoylcysteine decarboxylase / phosphopantothenate-cysteine ligase (CTP) / phosphopantothenate--cysteine ligase activity / phosphopantothenoylcysteine decarboxylase complex / phosphopantothenoylcysteine decarboxylase activity / coenzyme A biosynthetic process / FMN binding / metal ion binding Similarity search - Function Coenzyme A biosynthesis bifunctional protein CoaBC / DNA/pantothenate metabolism flavoprotein, C-terminal / CoaB-like superfamily / DNA / pantothenate metabolism flavoprotein / Flavoprotein / Flavin prenyltransferase-like / Flavoprotein Similarity search - Domain/homologyBiological species Mycolicibacterium smegmatis (bacteria)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 2.033 Å DetailsAuthors Mendes, V. / Blaszczyk, M. / Bryant, O. / Cory-Wright, J. / Blundell, T.L. Funding support 1items Details Hide detailsOrganization Grant number Country Bill & Melinda Gates Foundation
CitationJournal : Nat Commun / Year : 2021Title : Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site.Authors: Mendes, V. / Green, S.R. / Evans, J.C. / Hess, J. / Blaszczyk, M. / Spry, C. / Bryant, O. / Cory-Wright, J. / Chan, D.S. / Torres, P.H.M. / Wang, Z. / Nahiyaan, N. / O'Neill, S. / Damerow, S. ... Authors : Mendes, V. / Green, S.R. / Evans, J.C. / Hess, J. / Blaszczyk, M. / Spry, C. / Bryant, O. / Cory-Wright, J. / Chan, D.S. / Torres, P.H.M. / Wang, Z. / Nahiyaan, N. / O'Neill, S. / Damerow, S. / Post, J. / Bayliss, T. / Lynch, S.L. / Coyne, A.G. / Ray, P.C. / Abell, C. / Rhee, K.Y. / Boshoff, H.I.M. / Barry, C.E. / Mizrahi, V. / Wyatt, P.G. / Blundell, T.L. History Deposition Nov 19, 2019 Deposition site : PDBE / Processing site : PDBERevision 1.0 Nov 25, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Jan 20, 2021 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jan 24, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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