登録情報 | データベース: PDB / ID: 6tb2 |
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タイトル | Structure of human haptoglobin-hemoglobin bound to S. aureus IsdH |
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要素 | - Cell wall surface anchor family protein
- Haptoglobin
- Hemoglobin subunit alpha
- Hemoglobin subunit beta
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キーワード | METAL TRANSPORT / Hemoglobin receptor / heme acquisition / inhibitor |
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機能・相同性 | 機能・相同性情報
negative regulation of hydrogen peroxide catabolic process / negative regulation of oxidoreductase activity / cell wall / nitric oxide transport / hemoglobin binding / immune system process / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / renal absorption ...negative regulation of hydrogen peroxide catabolic process / negative regulation of oxidoreductase activity / cell wall / nitric oxide transport / hemoglobin binding / immune system process / hemoglobin alpha binding / haptoglobin binding / haptoglobin-hemoglobin complex / renal absorption / organic acid binding / hemoglobin complex / antioxidant activity / oxygen transport / Scavenging of heme from plasma / endocytic vesicle lumen / blood vessel diameter maintenance / acute-phase response / hydrogen peroxide catabolic process / oxygen carrier activity / Late endosomal microautophagy / Heme signaling / carbon dioxide transport / response to hydrogen peroxide / Erythrocytes take up oxygen and release carbon dioxide / Erythrocytes take up carbon dioxide and release oxygen / Cytoprotection by HMOX1 / defense response / oxygen binding / regulation of blood pressure / platelet aggregation / Chaperone Mediated Autophagy / peroxidase activity / specific granule lumen / positive regulation of nitric oxide biosynthetic process / tertiary granule lumen / Factors involved in megakaryocyte development and platelet production / ficolin-1-rich granule lumen / blood microparticle / defense response to bacterium / iron ion binding / serine-type endopeptidase activity / heme binding / Neutrophil degranulation / extracellular space / extracellular exosome / extracellular region / membrane / metal ion binding / cytosol類似検索 - 分子機能 Iron-regulated surface determinant protein H / NEAT domain / Iron Transport-associated domain / NEAT domain profile. / NEAr Transporter domain / NEAT domain superfamily / YSIRK type signal peptide / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily ...Iron-regulated surface determinant protein H / NEAT domain / Iron Transport-associated domain / NEAT domain profile. / NEAr Transporter domain / NEAT domain superfamily / YSIRK type signal peptide / Sushi/SCR/CCP domain / Sushi/CCP/SCR domain profile. / Sushi/SCR/CCP superfamily / Hemoglobin, pi / YSIRK Gram-positive signal peptide / Hemoglobin, alpha-type / Hemoglobin, beta-type / Gram-positive cocci surface proteins LPxTG motif profile. / LPXTG cell wall anchor domain / Globin/Protoglobin / Globins / Globin domain profile. / Globin-like / Globin / Globin / Globin-like superfamily / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin domain profile. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Orthogonal Bundle / Mainly Alpha類似検索 - ドメイン・相同性 PROTOPORPHYRIN IX CONTAINING FE / Haptoglobin receptor A / Haptoglobin / Hemoglobin subunit beta / Hemoglobin subunit alpha / Iron-regulated surface determinant protein H類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト)
![](img/tx_bacteria.gif) Staphylococcus aureus (黄色ブドウ球菌) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 2.9 Å |
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データ登録者 | Mikkelsen, J.H. / Andersen, C.B.F. |
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資金援助 | デンマーク, 1件 組織 | 認可番号 | 国 |
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Lundbeckfonden | R191-2015-733 | デンマーク |
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引用 | ジャーナル: To Be Published タイトル: Haptoglobin is an inhibitor of Staphylococcus aureus IsdH-mediated heme-sequestering 著者: Mikkelsen, J.H. / Runager, K.S. / Andersen, C.B.F. |
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履歴 | 登録 | 2019年10月31日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年12月18日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2024年1月24日 | Group: Data collection / Database references ...Data collection / Database references / Derived calculations / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_conn_type Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_ptnr2_label_alt_id / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn_type.id |
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