登録情報 | データベース: PDB / ID: 6ro1 |
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タイトル | X-ray crystal structure of the MTR4 NVL complex |
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要素 | - Exosome RNA helicase MTR4
- Nuclear valosin-containing protein-like
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キーワード | RNA BINDING PROTEIN / DExH helicase / Complex |
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機能・相同性 | 機能・相同性情報
snRNA catabolic process / regulation of protein localization to nucleolus / TRAMP complex / preribosome binding / telomerase holoenzyme complex / RNA catabolic process / maturation of 5.8S rRNA / : / Major pathway of rRNA processing in the nucleolus and cytosol / catalytic step 2 spliceosome ...snRNA catabolic process / regulation of protein localization to nucleolus / TRAMP complex / preribosome binding / telomerase holoenzyme complex / RNA catabolic process / maturation of 5.8S rRNA / : / Major pathway of rRNA processing in the nucleolus and cytosol / catalytic step 2 spliceosome / mRNA Splicing - Major Pathway / ribosomal large subunit biogenesis / mRNA splicing, via spliceosome / rRNA processing / ribosome biogenesis / positive regulation of protein binding / RNA helicase activity / RNA helicase / nuclear speck / DNA damage response / nucleolus / ATP hydrolysis activity / RNA binding / nucleoplasm / ATP binding / membrane / nucleus類似検索 - 分子機能 NVL2, nucleolin binding domain / NVL2, N-terminal domain superfamily / Nucleolin binding domain / : / rRNA-processing arch domain / Mtr4-like, beta-barrel domain / : / Exosome RNA helicase MTR4-like, stalk / ATP-dependent RNA helicase Ski2, C-terminal / ATP-dependent RNA helicase Ski2-like ...NVL2, nucleolin binding domain / NVL2, N-terminal domain superfamily / Nucleolin binding domain / : / rRNA-processing arch domain / Mtr4-like, beta-barrel domain / : / Exosome RNA helicase MTR4-like, stalk / ATP-dependent RNA helicase Ski2, C-terminal / ATP-dependent RNA helicase Ski2-like / DSHCT (NUC185) domain / DSHCT / AAA ATPase, AAA+ lid domain / AAA+ lid domain / ATPase, AAA-type, conserved site / AAA-protein family signature. / DEAD/DEAH box helicase / DEAD/DEAH box helicase domain / ATPase family associated with various cellular activities (AAA) / ATPase, AAA-type, core / Helicase conserved C-terminal domain / helicase superfamily c-terminal domain / Superfamilies 1 and 2 helicase C-terminal domain profile. / Superfamilies 1 and 2 helicase ATP-binding type-1 domain profile. / DEAD-like helicases superfamily / Helicase, C-terminal / Helicase superfamily 1/2, ATP-binding domain / ATPases associated with a variety of cellular activities / AAA+ ATPase domain / P-loop containing nucleoside triphosphate hydrolase類似検索 - ドメイン・相同性 ADENOSINE-5'-DIPHOSPHATE / Nuclear valosin-containing protein-like / Exosome RNA helicase MTR4類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 3.07 Å |
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データ登録者 | Lingaraju, M. / Langer, L.M. / Basquin, J. / Falk, S. / Conti, E. |
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資金援助 | ベルギー, ドイツ, 7件 組織 | 認可番号 | 国 |
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European Research Council | 294371 | ベルギー | German Research Foundation | SFB646 | ドイツ | German Research Foundation | SFB1035 | ドイツ | German Research Foundation | GRK1721 | ドイツ | German Research Foundation | FOR1680 | ドイツ | German Research Foundation | EXC114 | ドイツ | Max Planck Society | | ドイツ |
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引用 | ジャーナル: Nat Commun / 年: 2019 タイトル: The MTR4 helicase recruits nuclear adaptors of the human RNA exosome using distinct arch-interacting motifs. 著者: Lingaraju, M. / Johnsen, D. / Schlundt, A. / Langer, L.M. / Basquin, J. / Sattler, M. / Heick Jensen, T. / Falk, S. / Conti, E. |
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履歴 | 登録 | 2019年5月10日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年7月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年8月14日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.country / _citation.journal_abbrev ..._citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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