登録情報 データベース : PDB / ID : 6qc0 構造の表示 ダウンロードとリンクタイトル PCNA complex with Cdt2 C-terminal PIP-box peptide 要素Denticleless protein homolog Proliferating cell nuclear antigen 詳細キーワード REPLICATION / complex / PIP機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
positive regulation of deoxyribonuclease activity / dinucleotide insertion or deletion binding / PCNA-p21 complex / mitotic telomere maintenance via semi-conservative replication / purine-specific mismatch base pair DNA N-glycosylase activity / nuclear lamina / positive regulation of DNA-directed DNA polymerase activity / Polymerase switching / MutLalpha complex binding / Telomere C-strand (Lagging Strand) Synthesis ... positive regulation of deoxyribonuclease activity / dinucleotide insertion or deletion binding / PCNA-p21 complex / mitotic telomere maintenance via semi-conservative replication / purine-specific mismatch base pair DNA N-glycosylase activity / nuclear lamina / positive regulation of DNA-directed DNA polymerase activity / Polymerase switching / MutLalpha complex binding / Telomere C-strand (Lagging Strand) Synthesis / Processive synthesis on the lagging strand / PCNA complex / Removal of the Flap Intermediate / Processive synthesis on the C-strand of the telomere / Polymerase switching on the C-strand of the telomere / Mismatch repair (MMR) directed by MSH2:MSH3 (MutSbeta) / Mismatch repair (MMR) directed by MSH2:MSH6 (MutSalpha) / Removal of the Flap Intermediate from the C-strand / Transcription of E2F targets under negative control by DREAM complex / replisome / response to L-glutamate / Cul4A-RING E3 ubiquitin ligase complex / Cul4-RING E3 ubiquitin ligase complex / Cul4B-RING E3 ubiquitin ligase complex / response to dexamethasone / histone acetyltransferase binding / DNA polymerase processivity factor activity / leading strand elongation / G1/S-Specific Transcription / mitotic G2 DNA damage checkpoint signaling / replication fork processing / nuclear replication fork / SUMOylation of DNA replication proteins / PCNA-Dependent Long Patch Base Excision Repair / protein monoubiquitination / positive regulation of G2/M transition of mitotic cell cycle / response to cadmium ion / translesion synthesis / mismatch repair / estrous cycle / response to UV / cyclin-dependent protein kinase holoenzyme complex / Translesion synthesis by REV1 / Translesion synthesis by POLK / base-excision repair, gap-filling / DNA polymerase binding / Translesion synthesis by POLI / Gap-filling DNA repair synthesis and ligation in GG-NER / epithelial cell differentiation / liver regeneration / positive regulation of DNA repair / TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest / Termination of translesion DNA synthesis / positive regulation of DNA replication / replication fork / Recognition of DNA damage by PCNA-containing replication complex / nuclear estrogen receptor binding / Translesion Synthesis by POLH / male germ cell nucleus / HDR through Homologous Recombination (HRR) / Dual Incision in GG-NER / receptor tyrosine kinase binding / Dual incision in TC-NER / Gap-filling DNA repair synthesis and ligation in TC-NER / cellular response to hydrogen peroxide / cellular response to xenobiotic stimulus / protein polyubiquitination / positive regulation of protein catabolic process / cellular response to UV / rhythmic process / E3 ubiquitin ligases ubiquitinate target proteins / response to estradiol / Neddylation / chromosome / heart development / chromatin organization / ubiquitin-dependent protein catabolic process / protein-macromolecule adaptor activity / nuclear membrane / damaged DNA binding / proteasome-mediated ubiquitin-dependent protein catabolic process / chromosome, telomeric region / DNA replication / regulation of cell cycle / nuclear body / centrosome / DNA damage response / chromatin binding / chromatin / protein-containing complex binding / nucleolus / enzyme binding / negative regulation of transcription by RNA polymerase II / extracellular exosome / nucleoplasm / identical protein binding / nucleus / cytosol 類似検索 - 分子機能 : / Box / Proliferating Cell Nuclear Antigen / Proliferating Cell Nuclear Antigen - #10 / Proliferating cell nuclear antigen signature 2. / Proliferating cell nuclear antigen, PCNA, conserved site / Proliferating cell nuclear antigen signature 1. / Proliferating cell nuclear antigen, PCNA / Proliferating cell nuclear antigen, PCNA, N-terminal / Proliferating cell nuclear antigen, PCNA, C-terminal ... : / Box / Proliferating Cell Nuclear Antigen / Proliferating Cell Nuclear Antigen - #10 / Proliferating cell nuclear antigen signature 2. / Proliferating cell nuclear antigen, PCNA, conserved site / Proliferating cell nuclear antigen signature 1. / Proliferating cell nuclear antigen, PCNA / Proliferating cell nuclear antigen, PCNA, N-terminal / Proliferating cell nuclear antigen, PCNA, C-terminal / Proliferating cell nuclear antigen, N-terminal domain / Proliferating cell nuclear antigen, C-terminal domain / : / WD domain, G-beta repeat / WD40 repeat, conserved site / Trp-Asp (WD) repeats signature. / Trp-Asp (WD) repeats profile. / Trp-Asp (WD) repeats circular profile. / WD40 repeats / WD40 repeat / WD40-repeat-containing domain superfamily / WD40/YVTN repeat-like-containing domain superfamily / Alpha Beta 類似検索 - ドメイン・相同性 Proliferating cell nuclear antigen / Denticleless protein homolog 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 3.5 Å 詳細データ登録者 Perrakis, A.P. / von Castelmur, E. 引用ジャーナル : Life Sci Alliance / 年 : 2018タイトル : Direct binding of Cdt2 to PCNA is important for targeting the CRL4Cdt2E3 ligase activity to Cdt1.著者: Hayashi, A. / Giakoumakis, N.N. / Heidebrecht, T. / Ishii, T. / Panagopoulos, A. / Caillat, C. / Takahara, M. / Hibbert, R.G. / Suenaga, N. / Stadnik-Spiewak, M. / Takahashi, T. / Shiomi, Y. ... 著者 : Hayashi, A. / Giakoumakis, N.N. / Heidebrecht, T. / Ishii, T. / Panagopoulos, A. / Caillat, C. / Takahara, M. / Hibbert, R.G. / Suenaga, N. / Stadnik-Spiewak, M. / Takahashi, T. / Shiomi, Y. / Taraviras, S. / von Castelmur, E. / Lygerou, Z. / Perrakis, A. / Nishitani, H. 履歴 登録 2018年12月25日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年1月23日 Provider : repository / タイプ : Initial release改定 1.1 2024年5月15日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
すべて表示 表示を減らす