Entry Database : PDB / ID : 6p7j Structure visualization Downloads & linksTitle Crystal structure of Latency Associated Peptide unbound to TGF-beta1 ComponentsTransforming growth factor beta-1 proprotein Details Keywords CYTOKINE / pro-domain / latency / cancer / transformingFunction / homology Function and homology informationFunction Domain/homology Component
cellular response to acetaldehyde / frontal suture morphogenesis / Influenza Virus Induced Apoptosis / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / columnar/cuboidal epithelial cell maturation / negative regulation of skeletal muscle tissue development ... cellular response to acetaldehyde / frontal suture morphogenesis / Influenza Virus Induced Apoptosis / adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains / positive regulation of microglia differentiation / regulation of interleukin-23 production / branch elongation involved in mammary gland duct branching / positive regulation of primary miRNA processing / columnar/cuboidal epithelial cell maturation / negative regulation of skeletal muscle tissue development / embryonic liver development / regulation of branching involved in mammary gland duct morphogenesis / macrophage derived foam cell differentiation / response to laminar fluid shear stress / regulation of enamel mineralization / regulation of cartilage development / TGFBR2 MSI Frameshift Mutants in Cancer / regulation of striated muscle tissue development / regulatory T cell differentiation / regulation of blood vessel remodeling / tolerance induction to self antigen / regulation of protein import into nucleus / extracellular matrix assembly / negative regulation of natural killer cell mediated cytotoxicity directed against tumor cell target / negative regulation of hyaluronan biosynthetic process / type III transforming growth factor beta receptor binding / positive regulation of cardiac muscle cell differentiation / myofibroblast differentiation / odontoblast differentiation / positive regulation of odontogenesis / connective tissue replacement involved in inflammatory response wound healing / positive regulation of exit from mitosis / Langerhans cell differentiation / TGFBR2 Kinase Domain Mutants in Cancer / positive regulation of smooth muscle cell differentiation / negative regulation of macrophage cytokine production / positive regulation of isotype switching to IgA isotypes / positive regulation of mesenchymal stem cell proliferation / SMAD2/3 Phosphorylation Motif Mutants in Cancer / TGFBR1 KD Mutants in Cancer / membrane protein intracellular domain proteolysis / positive regulation of receptor signaling pathway via STAT / retina vasculature development in camera-type eye / positive regulation of extracellular matrix assembly / heart valve morphogenesis / TGFBR3 regulates TGF-beta signaling / mammary gland branching involved in thelarche / bronchiole development / hyaluronan catabolic process / positive regulation of vasculature development / lens fiber cell differentiation / negative regulation of extracellular matrix disassembly / ATP biosynthetic process / positive regulation of branching involved in ureteric bud morphogenesis / type II transforming growth factor beta receptor binding / receptor catabolic process / TGFBR1 LBD Mutants in Cancer / positive regulation of chemotaxis / type I transforming growth factor beta receptor binding / germ cell migration / negative regulation of biomineral tissue development / positive regulation of mononuclear cell migration / phospholipid homeostasis / response to salt / endoderm development / negative regulation of cell-cell adhesion mediated by cadherin / negative regulation of myoblast differentiation / positive regulation of vascular permeability / response to cholesterol / oligodendrocyte development / negative regulation of interleukin-17 production / cell-cell junction organization / surfactant homeostasis / deubiquitinase activator activity / phosphate-containing compound metabolic process / sprouting angiogenesis / negative regulation of release of sequestered calcium ion into cytosol / digestive tract development / aortic valve morphogenesis / negative regulation of ossification / positive regulation of chemokine (C-X-C motif) ligand 2 production / response to vitamin D / RUNX3 regulates CDKN1A transcription / positive regulation of fibroblast migration / face morphogenesis / neural tube development / positive regulation of regulatory T cell differentiation / ureteric bud development / Molecules associated with elastic fibres / positive regulation of peptidyl-tyrosine phosphorylation / negative regulation of phagocytosis / positive regulation of epidermal growth factor receptor signaling pathway / negative regulation of neuroblast proliferation / lung alveolus development / Syndecan interactions / cellular response to insulin-like growth factor stimulus / ventricular cardiac muscle tissue morphogenesis / muscle cell cellular homeostasis / negative regulation of fat cell differentiation / odontogenesis of dentin-containing tooth Similarity search - Function Transforming growth factor beta-1 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain ... Transforming growth factor beta-1 proprotein / Transforming growth factor-beta / TGF-beta, propeptide / TGF-beta propeptide / Transforming growth factor beta, conserved site / TGF-beta family signature. / Transforming growth factor-beta-related / Transforming growth factor-beta (TGF-beta) family / Transforming growth factor-beta, C-terminal / Transforming growth factor beta like domain / TGF-beta family profile. / Cystine-knot cytokine Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution : 3.501 Å DetailsAuthors Stachowski, T.R. / Snell, M.E. / Snell, E.H. Funding support United States, 1items Details Hide detailsOrganization Grant number Country National Science Foundation (NSF, United States) 1231306 United States
CitationJournal : Iucrj / Year : 2020Title : Structural insights into conformational switching in latency-associated peptide between transforming growth factor beta-1 bound and unbound statesAuthors : Stachowski, T.R. / Snell, M.E. / Snell, E.H. History Deposition Jun 5, 2019 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 11, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accessionRevision 1.2 Nov 13, 2024 Group : Structure summary / Category : pdbx_entry_details / pdbx_modification_feature
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