+Open data
-Basic information
Entry | Database: PDB / ID: 1dsu | ||||||
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Title | HUMAN FACTOR D, COMPLEMENT ACTIVATING ENZYME | ||||||
Components | FACTOR D | ||||||
Keywords | HYDROLASE (SERINE PROTEASE) / COMPLEMENT ACTIVATING ENZYME / HYDROLASE / SERINE PROTEASE | ||||||
Function / homology | Function and homology information complement factor D / Alternative complement activation / complement activation, alternative pathway / complement activation / serine-type peptidase activity / platelet alpha granule lumen / response to bacterium / Platelet degranulation / secretory granule lumen / ficolin-1-rich granule lumen ...complement factor D / Alternative complement activation / complement activation, alternative pathway / complement activation / serine-type peptidase activity / platelet alpha granule lumen / response to bacterium / Platelet degranulation / secretory granule lumen / ficolin-1-rich granule lumen / serine-type endopeptidase activity / Neutrophil degranulation / proteolysis / extracellular exosome / extracellular region Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / Resolution: 2 Å | ||||||
Authors | Narayana, S.V.L. / Volanakis, J.E. / Delucas, L.J. | ||||||
Citation | Journal: J.Mol.Biol. / Year: 1994 Title: Structure of human factor D. A complement system protein at 2.0 A resolution. Authors: Narayana, S.V. / Carson, M. / el-Kabbani, O. / Kilpatrick, J.M. / Moore, D. / Chen, X. / Bugg, C.E. / Volanakis, J.E. / DeLucas, L.J. #1: Journal: J.Mol.Biol. / Year: 1991 Title: Crystallization and Preliminary X-Ray Investigation of Factor D of Human Complement Authors: Narayana, S.V. / Kilpatrick, J.M. / El-Kabbani, O. / Babu, Y.S. / Bugg, C.E. / Volanakis, J.E. / Delucas, L.J. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 1dsu.cif.gz | 95.5 KB | Display | PDBx/mmCIF format |
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PDB format | pdb1dsu.ent.gz | 73.6 KB | Display | PDB format |
PDBx/mmJSON format | 1dsu.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Summary document | 1dsu_validation.pdf.gz | 425.7 KB | Display | wwPDB validaton report |
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Full document | 1dsu_full_validation.pdf.gz | 441.8 KB | Display | |
Data in XML | 1dsu_validation.xml.gz | 19.8 KB | Display | |
Data in CIF | 1dsu_validation.cif.gz | 27.1 KB | Display | |
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/ds/1dsu ftp://data.pdbj.org/pub/pdb/validation_reports/ds/1dsu | HTTPS FTP |
-Related structure data
Similar structure data |
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-Links
-Assembly
Deposited unit |
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1 |
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS oper: (Code: given Matrix: (0.3219, 0.08175, -0.91432), Vector: |
-Components
#1: Protein | Mass: 24438.807 Da / Num. of mol.: 2 / Source method: isolated from a natural source / Source: (natural) Homo sapiens (human) / References: UniProt: P00746, complement factor D #2: Water | ChemComp-HOH / | |
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-Experimental details
-Experiment
Experiment | Method: X-RAY DIFFRACTION |
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-Sample preparation
Crystal | Density Matthews: 1.98 Å3/Da / Density % sol: 37 % | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
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Crystal | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Crystal grow | *PLUS Temperature: 22 ℃ / pH: 5.4 / Method: vapor diffusion, hanging drop / Details: Narayana, S.V., (1991) J.Mol.Biol., 219, 1. | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Components of the solutions | *PLUS
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-Data collection
Diffraction source | Wavelength: 1.5418 |
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Detector | Type: XENTRONICS / Detector: AREA DETECTOR |
Radiation | Monochromatic (M) / Laue (L): M / Scattering type: x-ray |
Radiation wavelength | Wavelength: 1.5418 Å / Relative weight: 1 |
Reflection | Redundancy: 4 % / Rmerge(I) obs: 0.06 |
-Processing
Software |
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Refinement | Resolution: 2→7.5 Å / σ(F): 1.5
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Refinement step | Cycle: LAST / Resolution: 2→7.5 Å
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Refine LS restraints |
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Software | *PLUS Name: X-PLOR / Classification: refinement | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refinement | *PLUS Rfactor Rfree: 0.203 | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Solvent computation | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Displacement parameters | *PLUS | ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Refine LS restraints | *PLUS
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