登録情報 データベース : PDB / ID : 6oau 構造の表示 ダウンロードとリンクタイトル Apo Structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in GnTI-deficient HEK293-F cells 要素Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 Lipoprotein lipase 詳細キーワード HYDROLASE/PROTEIN BINDING / Lipase / HYDROLASE-PROTEIN BINDING complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
chylomicron binding / positive regulation of chylomicron remnant clearance / lipoprotein lipase / lipoprotein lipase activity / positive regulation of sequestering of triglyceride / low-density lipoprotein particle mediated signaling / chylomicron remodeling / response to heparin / positive regulation of cholesterol storage / lipoprotein lipase activator activity ... chylomicron binding / positive regulation of chylomicron remnant clearance / lipoprotein lipase / lipoprotein lipase activity / positive regulation of sequestering of triglyceride / low-density lipoprotein particle mediated signaling / chylomicron remodeling / response to heparin / positive regulation of cholesterol storage / lipoprotein lipase activator activity / lipase binding / phospholipase A1 / phosphatidylserine 1-acylhydrolase activity / 1-acyl-2-lysophosphatidylserine acylhydrolase activity / phospholipase A1 activity / triglyceride catabolic process / phospholipase activity / Assembly of active LPL and LIPC lipase complexes / Post-translational modification: synthesis of GPI-anchored proteins / positive regulation of lipoprotein lipase activity / protein transporter activity / very-low-density lipoprotein particle remodeling / positive regulation of macrophage derived foam cell differentiation / Chylomicron remodeling / positive regulation of lipid storage / acetylcholine receptor inhibitor activity / cellular response to nutrient / chylomicron / high-density lipoprotein particle remodeling / very-low-density lipoprotein particle / transcytosis / protein import / triacylglycerol lipase activity / heparan sulfate proteoglycan binding / positive regulation of chemokine (C-X-C motif) ligand 2 production / protein localization to cell surface / triglyceride homeostasis / cellular response to fatty acid / triglyceride metabolic process / lipoprotein particle binding / apolipoprotein binding / catalytic complex / positive regulation of fat cell differentiation / phospholipid metabolic process / response to glucose / positive regulation of chemokine production / Retinoid metabolism and transport / protein-membrane adaptor activity / positive regulation of adipose tissue development / fatty acid metabolic process / positive regulation of interleukin-1 beta production / cholesterol homeostasis / response to bacterium / intracellular protein transport / fatty acid biosynthetic process / Transcriptional regulation of white adipocyte differentiation / positive regulation of inflammatory response / positive regulation of interleukin-6 production / positive regulation of tumor necrosis factor production / heparin binding / basolateral plasma membrane / protein stabilization / apical plasma membrane / external side of plasma membrane / signaling receptor binding / lipid binding / calcium ion binding / cell surface / protein homodimerization activity / extracellular space / extracellular region / plasma membrane 類似検索 - 分子機能 Lipoprotein lipase / Lipase, LIPH-type / Lipase, N-terminal / Triacylglycerol lipase family / Lipase / Lipase / u-PAR/Ly-6 domain / Ly-6 antigen/uPA receptor-like / Lipoxygenase homology 2 (beta barrel) domain / PLAT/LH2 domain ... Lipoprotein lipase / Lipase, LIPH-type / Lipase, N-terminal / Triacylglycerol lipase family / Lipase / Lipase / u-PAR/Ly-6 domain / Ly-6 antigen/uPA receptor-like / Lipoxygenase homology 2 (beta barrel) domain / PLAT/LH2 domain / PLAT/LH2 domain superfamily / PLAT/LH2 domain / PLAT domain profile. / Lipases, serine active site. / Snake toxin-like superfamily / Alpha/Beta hydrolase fold 類似検索 - ドメイン・相同性 MALONATE ION / Lipoprotein lipase / Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.48 Å 詳細データ登録者 Arora, R. / Horton, P.A. / Benson, T.E. / Romanowski, M.J. 引用ジャーナル : Proc.Natl.Acad.Sci.USA / 年 : 2019タイトル : Structure of lipoprotein lipase in complex with GPIHBP1.著者: Arora, R. / Nimonkar, A.V. / Baird, D. / Wang, C. / Chiu, C.H. / Horton, P.A. / Hanrahan, S. / Cubbon, R. / Weldon, S. / Tschantz, W.R. / Mueller, S. / Brunner, R. / Lehr, P. / Meier, P. / ... 著者 : Arora, R. / Nimonkar, A.V. / Baird, D. / Wang, C. / Chiu, C.H. / Horton, P.A. / Hanrahan, S. / Cubbon, R. / Weldon, S. / Tschantz, W.R. / Mueller, S. / Brunner, R. / Lehr, P. / Meier, P. / Ottl, J. / Voznesensky, A. / Pandey, P. / Smith, T.M. / Stojanovic, A. / Flyer, A. / Benson, T.E. / Romanowski, M.J. / Trauger, J.W. 履歴 登録 2019年3月18日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2019年5月8日 Provider : repository / タイプ : Initial release改定 1.1 2019年5月22日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.pdbx_database_id_PubMed / _citation.title ... _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name 改定 1.2 2019年6月5日 Group : Data collection / Database references / カテゴリ : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_last改定 1.3 2020年7月29日 Group : Data collection / Derived calculations / Structure summaryカテゴリ : chem_comp / entity ... chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item : _chem_comp.name / _chem_comp.type ... _chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.pdbx_role / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id 解説 : Carbohydrate remediation / Provider : repository / タイプ : Remediation改定 1.4 2023年10月11日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description / Structure summary カテゴリ : chem_comp / chem_comp_atom ... chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item : _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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