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Structure paper

TitleStructure of lipoprotein lipase in complex with GPIHBP1.
Journal, issue, pagesProc. Natl. Acad. Sci. USA, Vol. 116, Page 10360-10365, Year 2019
Publish dateMar 18, 2019 (structure data deposition date)
AuthorsArora, R. / Nimonkar, A.V. / Baird, D. / Wang, C. / Chiu, C.H. / Horton, P.A. / Hanrahan, S. / Cubbon, R. / Weldon, S. / Tschantz, W.R. ...Arora, R. / Nimonkar, A.V. / Baird, D. / Wang, C. / Chiu, C.H. / Horton, P.A. / Hanrahan, S. / Cubbon, R. / Weldon, S. / Tschantz, W.R. / Mueller, S. / Brunner, R. / Lehr, P. / Meier, P. / Ottl, J. / Voznesensky, A. / Pandey, P. / Smith, T.M. / Stojanovic, A. / Flyer, A. / Benson, T.E. / Romanowski, M.J. / Trauger, J.W.
External linksProc. Natl. Acad. Sci. USA / PubMed:31072929
MethodsX-ray diffraction
Resolution2.48 - 3.04 Å
Structure data

PDB-6oau:
Apo Structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in GnTI-deficient HEK293-F cells
Method: X-RAY DIFFRACTION / Resolution: 2.48 Å

PDB-6oaz:
Apo Structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in HEK293-F cells
Method: X-RAY DIFFRACTION / Resolution: 3.04 Å

PDB-6ob0:
Compound 2 bound structure of WT Lipoprotein Lipase in Complex with GPIHBP1 Mutant N78D N82D produced in HEK293-F cells
Method: X-RAY DIFFRACTION / Resolution: 2.81 Å

Chemicals

ChemComp-NAG:
2-acetamido-2-deoxy-beta-D-glucopyranose

ChemComp-MLI:
MALONATE ION

ChemComp-CA:
Unknown entry

ChemComp-HOH:
WATER

ChemComp-EDO:
1,2-ETHANEDIOL

ChemComp-M3D:
7-(3-cyano-4-hydroxyphenyl)-N-[2-(morpholin-4-yl)ethyl]dibenzo[b,f]oxepine-10-carboxamide

ChemComp-TRS:
2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL / pH buffer*YM

Source
  • homo sapiens (human)
KeywordsHYDROLASE/PROTEIN BINDING / Lipase / HYDROLASE-PROTEIN BINDING complex

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