登録情報 データベース : PDB / ID : 6o5o 構造の表示 ダウンロードとリンクタイトル Crystal Structure of the Disabled-2 (Dab2) Dab Homology Domain in Complex with Peptide STA02 要素ACE-QNGFDNPNYQPQENMQA Disabled homolog 2 詳細キーワード ENDOCYTOSIS / Peptide Binding / Peptide Inhibitor / Protein-protein Interaction機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
leading edge cell differentiation / positive regulation of aldosterone biosynthetic process / positive regulation of aldosterone secretion / positive regulation of clathrin-dependent endocytosis / positive regulation of early endosome to late endosome transport / negative regulation of androgen receptor signaling pathway / clathrin coat assembly / positive regulation of Wnt signaling pathway, planar cell polarity pathway / clathrin-coated vesicle membrane / clathrin adaptor activity ... leading edge cell differentiation / positive regulation of aldosterone biosynthetic process / positive regulation of aldosterone secretion / positive regulation of clathrin-dependent endocytosis / positive regulation of early endosome to late endosome transport / negative regulation of androgen receptor signaling pathway / clathrin coat assembly / positive regulation of Wnt signaling pathway, planar cell polarity pathway / clathrin-coated vesicle membrane / clathrin adaptor activity / Formation of annular gap junctions / Gap junction degradation / response to salt / negative regulation of protein localization to plasma membrane / response to steroid hormone / cargo receptor activity / clathrin-coated vesicle / low-density lipoprotein particle receptor binding / SMAD binding / positive regulation of endocytosis / positive regulation of SMAD protein signal transduction / positive regulation of epithelial to mesenchymal transition / positive regulation of substrate adhesion-dependent cell spreading / clathrin-coated pit / cellular response to epidermal growth factor stimulus / transforming growth factor beta receptor signaling pathway / receptor-mediated endocytosis / negative regulation of protein binding / negative regulation of canonical Wnt signaling pathway / negative regulation of cell growth / negative regulation of ERK1 and ERK2 cascade / Wnt signaling pathway / fibrillar center / negative regulation of epithelial cell proliferation / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein transport / negative regulation of neuron projection development / Cargo recognition for clathrin-mediated endocytosis / Clathrin-mediated endocytosis / positive regulation of cell migration / positive regulation of protein phosphorylation / lysosomal membrane / intracellular membrane-bounded organelle / focal adhesion / negative regulation of apoptotic process / apoptotic process / perinuclear region of cytoplasm / negative regulation of transcription by RNA polymerase II / positive regulation of transcription by RNA polymerase II / plasma membrane / cytosol / cytoplasm 類似検索 - 分子機能 : / : / Disabled homolog 2-like, sulfatide-binding motifs / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / PH-like domain superfamily ... : / : / Disabled homolog 2-like, sulfatide-binding motifs / Phosphotyrosine interaction domain (PTB/PID) / Phosphotyrosine interaction domain (PID) profile. / Phosphotyrosine-binding domain, phosphotyrosine-interaction (PI) domain / PTB/PI domain / Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB) / PH-domain like / PH-like domain superfamily / Roll / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 1.75 Å 詳細データ登録者 Chavez, M. / Madden, D.R. 資金援助 米国, 3件 詳細 詳細を隠す組織 認可番号 国 National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) R01-DK104847 米国 National Institutes of Health/National Institute of General Medical Sciences (NIH/NIGMS) P20-GM113132 米国 National Institutes of Health/National Institute of Diabetes and Digestive and Kidney Disease (NIH/NIDDK) P30-DK-117469 米国
引用ジャーナル : To Be Published タイトル : Crystal Structure of the Disabled-2 (Dab2) Dab Homology Domain in Complex with Peptide STA02著者 : Chavez, M. / Madden, D.R. 履歴 登録 2019年3月4日 登録サイト : RCSB / 処理サイト : RCSB改定 1.0 2020年3月11日 Provider : repository / タイプ : Initial release改定 1.1 2023年10月11日 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Derived calculations / Refinement description カテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_struct_conn_angle / pdbx_unobs_or_zero_occ_atoms / pdbx_unobs_or_zero_occ_residues / struct_conn / struct_conn_type Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _pdbx_struct_conn_angle.ptnr1_auth_comp_id / _pdbx_struct_conn_angle.ptnr1_auth_seq_id / _pdbx_struct_conn_angle.ptnr1_label_asym_id / _pdbx_struct_conn_angle.ptnr1_label_atom_id / _pdbx_struct_conn_angle.ptnr1_label_comp_id / _pdbx_struct_conn_angle.ptnr1_label_seq_id / _pdbx_struct_conn_angle.ptnr1_symmetry / _pdbx_struct_conn_angle.ptnr2_auth_comp_id / _pdbx_struct_conn_angle.ptnr2_auth_seq_id / _pdbx_struct_conn_angle.ptnr2_label_asym_id / _pdbx_struct_conn_angle.ptnr2_label_atom_id / _pdbx_struct_conn_angle.ptnr2_label_comp_id / _pdbx_struct_conn_angle.ptnr2_symmetry / _pdbx_struct_conn_angle.ptnr3_auth_comp_id / _pdbx_struct_conn_angle.ptnr3_auth_seq_id / _pdbx_struct_conn_angle.ptnr3_label_asym_id / _pdbx_struct_conn_angle.ptnr3_label_atom_id / _pdbx_struct_conn_angle.ptnr3_label_comp_id / _pdbx_struct_conn_angle.ptnr3_label_seq_id / _pdbx_struct_conn_angle.ptnr3_symmetry / _pdbx_struct_conn_angle.value / _struct_conn.conn_type_id / _struct_conn.id / _struct_conn.pdbx_dist_value / _struct_conn.pdbx_leaving_atom_flag / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_conn.ptnr2_label_seq_id / _struct_conn.ptnr2_symmetry / _struct_conn_type.id
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