Entry | Database: PDB / ID: 6o54 |
---|
Title | Crystal Structure of multi-drug resistant HIV-1 protease PR-S17 (D25N) |
---|
Components | HIV-1 protease |
---|
Keywords | HYDROLASE / Viral Protein / HIV PROTEASE |
---|
Function / homology | Function and homology information
Retropepsin-like catalytic domain / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily ...Retropepsin-like catalytic domain / Retropepsins / Retroviral aspartyl protease / Aspartyl protease, retroviral-type family profile. / Peptidase A2A, retrovirus, catalytic / Cathepsin D, subunit A; domain 1 / Acid Proteases / Aspartic peptidase, active site / Eukaryotic and viral aspartyl proteases active site. / Aspartic peptidase domain superfamily / Beta Barrel / Mainly BetaSimilarity search - Domain/homology |
---|
Biological species | ![](img/tx_virus.gif) Human immunodeficiency virus 1 |
---|
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 1.21 Å |
---|
Authors | Wang, Y.-F. / Brothers, R. / Agniswamy, J. / Weber, I.T. |
---|
Funding support | United States, 1items Organization | Grant number | Country |
---|
National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | GM062920 | United States |
|
---|
Citation | Journal: Acs Omega / Year: 2019 Title: Highly Drug-Resistant HIV-1 Protease Mutant PRS17 Shows Enhanced Binding to Substrate Analogues. Authors: Agniswamy, J. / Kneller, D.W. / Brothers, R. / Wang, Y.F. / Harrison, R.W. / Weber, I.T. |
---|
History | Deposition | Mar 1, 2019 | Deposition site: RCSB / Processing site: RCSB |
---|
Revision 1.0 | Jun 19, 2019 | Provider: repository / Type: Initial release |
---|
Revision 1.1 | Jul 17, 2019 | Group: Data collection / Refinement description / Category: software Item: _software.classification / _software.name / _software.version |
---|
Revision 1.2 | Dec 18, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
---|
Revision 1.3 | Oct 11, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
---|
|
---|