登録情報 | データベース: PDB / ID: 6o39 |
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タイトル | Crystal structure of Frizzled 5 CRD in complex with F2.I Fab |
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要素 | - (Antibody F2.I Fab, ...) x 2
- Frizzled-5
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キーワード | SIGNALING PROTEIN / Receptor / Wnt / Frizzled / CRD / Antibody |
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機能・相同性 | 機能・相同性情報
regulation of chorionic trophoblast cell proliferation / Spemann organizer formation / syncytiotrophoblast cell differentiation involved in labyrinthine layer development / chorionic trophoblast cell differentiation / embryonic camera-type eye morphogenesis / glandular epithelial cell maturation / Signaling by RNF43 mutants / post-embryonic camera-type eye development / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / apoptotic process involved in morphogenesis ...regulation of chorionic trophoblast cell proliferation / Spemann organizer formation / syncytiotrophoblast cell differentiation involved in labyrinthine layer development / chorionic trophoblast cell differentiation / embryonic camera-type eye morphogenesis / glandular epithelial cell maturation / Signaling by RNF43 mutants / post-embryonic camera-type eye development / WNT5A-dependent internalization of FZD2, FZD5 and ROR2 / apoptotic process involved in morphogenesis / anterior/posterior axis specification, embryo / embryonic axis specification / cellular response to molecule of bacterial origin / intestinal epithelial cell maturation / Wnt receptor activity / non-canonical Wnt signaling pathway / regulation of mitophagy / eye development / Wnt-protein binding / branching involved in labyrinthine layer morphogenesis / Class B/2 (Secretin family receptors) / labyrinthine layer blood vessel development / Disassembly of the destruction complex and recruitment of AXIN to the membrane / positive regulation of protein targeting to mitochondrion / regulation of bicellular tight junction assembly / bicellular tight junction / canonical Wnt signaling pathway / synapse assembly / Regulation of FZD by ubiquitination / positive regulation of interleukin-1 beta production / Asymmetric localization of PCP proteins / clathrin-coated endocytic vesicle membrane / G protein-coupled receptor activity / positive regulation of T cell cytokine production / positive regulation of type II interferon production / neuron differentiation / positive regulation of tumor necrosis factor production / amyloid-beta binding / T cell differentiation in thymus / Ca2+ pathway / early endosome membrane / angiogenesis / perikaryon / axon / Golgi membrane / negative regulation of cell population proliferation / synapse / lipid binding / ubiquitin protein ligase binding / dendrite / protein-containing complex binding / protein kinase binding / perinuclear region of cytoplasm / cell surface / positive regulation of transcription by RNA polymerase II / plasma membrane類似検索 - 分子機能 Frizzled-5, CRD domain / Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily ...Frizzled-5, CRD domain / Frizzled cysteine-rich domain / Frizzled cysteine-rich domain / Frizzled/Smoothened, transmembrane domain / Frizzled/Smoothened family membrane region / Frizzled/Smoothened family membrane region / Frizzled/secreted frizzled-related protein / Frizzled / Frizzled domain / Frizzled cysteine-rich domain superfamily / Fz domain / Frizzled (fz) domain profile. / GPCR, family 2-like / G-protein coupled receptors family 2 profile 2. / Immunoglobulins / Immunoglobulin-like / Sandwich / Orthogonal Bundle / Mainly Beta / Mainly Alpha類似検索 - ドメイン・相同性 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.8 Å |
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データ登録者 | Raman, S. / Beilschmidt, M. / Fransson, J. / Julien, J.P. |
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引用 | ジャーナル: Proc. Natl. Acad. Sci. U.S.A. / 年: 2019 タイトル: Structure-guided design fine-tunes pharmacokinetics, tolerability, and antitumor profile of multispecific frizzled antibodies. 著者: Raman, S. / Beilschmidt, M. / To, M. / Lin, K. / Lui, F. / Jmeian, Y. / Ng, M. / Fernandez, M. / Fu, Y. / Mascall, K. / Duque, A. / Wang, X. / Pan, G. / Angers, S. / Moffat, J. / Sidhu, S.S. ...著者: Raman, S. / Beilschmidt, M. / To, M. / Lin, K. / Lui, F. / Jmeian, Y. / Ng, M. / Fernandez, M. / Fu, Y. / Mascall, K. / Duque, A. / Wang, X. / Pan, G. / Angers, S. / Moffat, J. / Sidhu, S.S. / Magram, J. / Sinclair, A.M. / Fransson, J. / Julien, J.P. |
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履歴 | 登録 | 2019年2月26日 | 登録サイト: RCSB / 処理サイト: RCSB |
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改定 1.0 | 2019年4月3日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年4月17日 | Group: Data collection / Database references / カテゴリ: citation / citation_author Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2020年7月29日 | Group: Data collection / Derived calculations / Structure summary カテゴリ: chem_comp / entity ...chem_comp / entity / pdbx_chem_comp_identifier / pdbx_entity_nonpoly / struct_conn / struct_site / struct_site_gen Item: _chem_comp.name / _chem_comp.type ..._chem_comp.name / _chem_comp.type / _entity.pdbx_description / _pdbx_entity_nonpoly.name / _struct_conn.pdbx_role 解説: Carbohydrate remediation / Provider: repository / タイプ: Remediation |
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改定 1.3 | 2023年10月11日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description / Structure summary カテゴリ: chem_comp / chem_comp_atom ...chem_comp / chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item: _chem_comp.pdbx_synonyms / _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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改定 1.4 | 2024年11月20日 | Group: Structure summary カテゴリ: pdbx_entry_details / pdbx_modification_feature |
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