Entry Database : PDB / ID : 6nmb Structure visualization Downloads & linksTitle Tranexamic Acid is an Active Site Inhibitor of Urokinase Plasminogen Activator ComponentsUrokinase-type plasminogen activator Details Keywords HYDROLASE / serine protease / fibrinolysis / inhibitorFunction / homology Function and homology informationFunction Domain/homology Component
u-plasminogen activator / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / regulation of wound healing / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / regulation of smooth muscle cell migration / regulation of signaling receptor activity ... u-plasminogen activator / regulation of smooth muscle cell-matrix adhesion / urokinase plasminogen activator signaling pathway / regulation of plasminogen activation / regulation of fibrinolysis / regulation of wound healing / protein complex involved in cell-matrix adhesion / negative regulation of plasminogen activation / regulation of smooth muscle cell migration / regulation of signaling receptor activity / serine-type endopeptidase complex / Dissolution of Fibrin Clot / smooth muscle cell migration / plasminogen activation / regulation of cell adhesion mediated by integrin / tertiary granule membrane / negative regulation of fibrinolysis / regulation of cell adhesion / specific granule membrane / serine protease inhibitor complex / fibrinolysis / chemotaxis / blood coagulation / regulation of cell population proliferation / response to hypoxia / positive regulation of cell migration / external side of plasma membrane / serine-type endopeptidase activity / focal adhesion / Neutrophil degranulation / cell surface / signal transduction / proteolysis / extracellular space / extracellular exosome / extracellular region / plasma membrane Similarity search - Function Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / : / Kringle-like fold / EGF-like domain profile. ... Kringle domain / Kringle / Kringle, conserved site / Kringle superfamily / Kringle domain signature. / Kringle domain profile. / Kringle domain / : / Kringle-like fold / EGF-like domain profile. / EGF-like domain signature 1. / EGF-like domain / Serine proteases, trypsin family, histidine active site / Serine proteases, trypsin family, serine active site / Peptidase S1A, chymotrypsin family / Serine proteases, trypsin family, histidine active site. / Serine proteases, trypsin domain profile. / Serine proteases, trypsin family, serine active site. / Trypsin-like serine protease / Serine proteases, trypsin domain / Trypsin / Trypsin-like serine proteases / Thrombin, subunit H / Peptidase S1, PA clan, chymotrypsin-like fold / Peptidase S1, PA clan / Beta Barrel / Mainly Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.3 Å DetailsAuthors Law, R.H.P. / Wu, G. CitationJournal : Blood Adv / Year : 2019Title : Tranexamic acid is an active site inhibitor of urokinase plasminogen activator.Authors : Wu, G. / Mazzitelli, B.A. / Quek, A.J. / Veldman, M.J. / Conroy, P.J. / Caradoc-Davies, T.T. / Ooms, L.M. / Tuck, K.L. / Schoenecker, J.G. / Whisstock, J.C. / Law, R.H.P. History Deposition Jan 10, 2019 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Mar 6, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Mar 20, 2019 Group : Data collection / Derived calculations / Category : pdbx_struct_assembly_gen / Item : _pdbx_struct_assembly_gen.asym_id_listRevision 1.2 Nov 13, 2019 Group : Database references / Category : citation / citation_authorItem : _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed ... _citation.journal_id_ISSN / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID Revision 1.3 Oct 11, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
Show all Show less