Entry | Database: PDB / ID: 6n3f |
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Title | Structure of HIV Tat-specific factor 1 U2AF Homology Motif bound to SF3b1 ULM5 |
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Components | - HIV Tat-specific factor 1
- SF3b1 U2AF ligand motif
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Keywords | PEPTIDE BINDING PROTEIN / HIV Tat-specific factor 1 / TAT-SF1 / RNA SPLICING FACTOR / U2AF HOMOLOGY MOTIF / UHM / RNA BINDING PROTEIN / U2AF LIGAND MOTIF / ULM / PROTEIN-PEPTIDE COMPLEX / PRE-MRNA SPLICING FACTOR / Sf3b1 |
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Function / homology | Function and homology information
U11/U12 snRNP / chromatin-protein adaptor activity / B-WICH complex / splicing factor binding / U12-type spliceosomal complex / protein localization to site of double-strand break / poly-ADP-D-ribose modification-dependent protein binding / RNA splicing, via transesterification reactions / U2-type spliceosomal complex / U2-type precatalytic spliceosome ...U11/U12 snRNP / chromatin-protein adaptor activity / B-WICH complex / splicing factor binding / U12-type spliceosomal complex / protein localization to site of double-strand break / poly-ADP-D-ribose modification-dependent protein binding / RNA splicing, via transesterification reactions / U2-type spliceosomal complex / U2-type precatalytic spliceosome / U2-type prespliceosome assembly / U2 snRNP / positive regulation of transcription by RNA polymerase III / U2-type prespliceosome / positive regulation of transcription by RNA polymerase I / spliceosomal complex assembly / mRNA Splicing - Minor Pathway / catalytic step 2 spliceosome / RNA splicing / mRNA Splicing - Major Pathway / spliceosomal complex / double-strand break repair via homologous recombination / B-WICH complex positively regulates rRNA expression / mRNA splicing, via spliceosome / site of double-strand break / nuclear speck / chromatin remodeling / mRNA binding / nucleolus / positive regulation of transcription by RNA polymerase II / RNA binding / nucleoplasm / nucleusSimilarity search - Function TatSF1-like, RNA recognition motif 1 / TatSF1-like / Splicing factor 3B subunit 1 / Splicing factor 3B subunit 1 / Splicing factor 3B subunit 1-like / RRM (RNA recognition motif) domain / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain ...TatSF1-like, RNA recognition motif 1 / TatSF1-like / Splicing factor 3B subunit 1 / Splicing factor 3B subunit 1 / Splicing factor 3B subunit 1-like / RRM (RNA recognition motif) domain / RNA recognition motif / RNA recognition motif / Eukaryotic RNA Recognition Motif (RRM) profile. / RNA recognition motif domain / RNA-binding domain superfamily / Armadillo-like helical / Armadillo-type fold / Nucleotide-binding alpha-beta plait domain superfamily / Alpha-Beta Plaits / 2-Layer Sandwich / Alpha BetaSimilarity search - Domain/homology |
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Biological species | Homo sapiens (human) |
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Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.099 Å |
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Authors | Leach, J.R. / Jenkins, J.L. / Kielkopf, C.L. |
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Funding support | United States, 2items Organization | Grant number | Country |
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National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | GM117005 | United States | National Institutes of Health/National Human Genome Research Institute (NIH/NHGRI) | GM070503 | United States |
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Citation | Journal: J. Biol. Chem. / Year: 2019 Title: The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface. Authors: Loerch, S. / Leach, J.R. / Horner, S.W. / Maji, D. / Jenkins, J.L. / Pulvino, M.J. / Kielkopf, C.L. |
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History | Deposition | Nov 15, 2018 | Deposition site: RCSB / Processing site: RCSB |
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Revision 1.0 | Jan 2, 2019 | Provider: repository / Type: Initial release |
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Revision 1.1 | Mar 6, 2019 | Group: Data collection / Database references / Category: citation / citation_author / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year / _citation_author.name |
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Revision 1.2 | Dec 18, 2019 | Group: Author supporting evidence / Category: pdbx_audit_support / Item: _pdbx_audit_support.funding_organization |
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Revision 1.3 | Mar 13, 2024 | Group: Data collection / Database references / Category: chem_comp_atom / chem_comp_bond / database_2 Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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