- PDB-6me9: XFEL crystal structure of human melatonin receptor MT2 in complex... -
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基本情報
登録情報
データベース: PDB / ID: 6me9
タイトル
XFEL crystal structure of human melatonin receptor MT2 in complex with ramelteon
要素
Soluble cytochrome b562,Melatonin receptor type 1B,Rubredoxin
キーワード
MEMBRANE PROTEIN / GPCR / melatonin receptor type 1B (MT2) / ramelteon / XFEL / LCP / BRIL / Rubredoxin / circadian rhythm / jetlag / type 2 diabetes
機能・相同性
機能・相同性情報
positive regulation of circadian sleep/wake cycle, non-REM sleep / melatonin receptor activity / regulation of neuronal action potential / negative regulation of transmission of nerve impulse / positive regulation of transmission of nerve impulse / alkane catabolic process / Class A/1 (Rhodopsin-like receptors) / camera-type eye development / negative regulation of vasoconstriction / negative regulation of cGMP-mediated signaling ...positive regulation of circadian sleep/wake cycle, non-REM sleep / melatonin receptor activity / regulation of neuronal action potential / negative regulation of transmission of nerve impulse / positive regulation of transmission of nerve impulse / alkane catabolic process / Class A/1 (Rhodopsin-like receptors) / camera-type eye development / negative regulation of vasoconstriction / negative regulation of cGMP-mediated signaling / negative regulation of cytosolic calcium ion concentration / regulation of insulin secretion / G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger / negative regulation of insulin secretion / G protein-coupled receptor activity / electron transport chain / glucose homeostasis / G alpha (i) signalling events / chemical synaptic transmission / negative regulation of neuron apoptotic process / periplasmic space / electron transfer activity / iron ion binding / G protein-coupled receptor signaling pathway / synapse / heme binding / plasma membrane 類似検索 - 分子機能