Entry Database : PDB / ID : 6mcp Structure visualization Downloads & linksTitle L. pneumophila effector kinase LegK7 (AMP-PNP bound) in complex with human MOB1A ComponentsLegK7 MOB kinase activator 1A DetailsKeywords TRANSFERASE / translocated effector / Ser/Thr protein kinase / allosteric activation / Hippo pathwayFunction / homology Function and homology informationFunction Domain/homology Component
hippo signaling / Signaling by Hippo / protein kinase activator activity / positive regulation of protein phosphorylation / extracellular exosome / nucleus / metal ion binding / cytoplasm / cytosol Similarity search - Function MOB kinase activator / MOB kinase activator family / MOB kinase activator superfamily / Mob1/phocein family / Mob1/phocein family / Butyryl-CoA Dehydrogenase, subunit A; domain 3 / Protein kinase-like domain superfamily / Up-down Bundle / Mainly Alpha Similarity search - Domain/homology PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER / : / DI(HYDROXYETHYL)ETHER / Protein kinase domain containing protein / MOB kinase activator 1A Similarity search - ComponentBiological species Legionella pneumophila subsp. pneumophila (bacteria)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.5 Å DetailsAuthors Beyrakhova, K.A. / Xu, C. / Boniecki, M.T. / Cygler, M. Funding support Canada, 1items Details Hide detailsOrganization Grant number Country Canadian Institutes of Health Research (CIHR) MOP-48370 Canada
CitationJournal : Proc.Natl.Acad.Sci.USA / Year : 2020Title : TheLegionellakinase LegK7 exploits the Hippo pathway scaffold protein MOB1A for allostery and substrate phosphorylation.Authors : Lee, P.C. / Beyrakhova, K. / Xu, C. / Boniecki, M.T. / Lee, M.H. / Onu, C.J. / Grishin, A.M. / Machner, M.P. / Cygler, M. History Deposition Sep 1, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Sep 4, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jan 8, 2020 Group : Author supporting evidence / Category : pdbx_audit_support / Item : _pdbx_audit_support.funding_organizationRevision 1.2 Jun 10, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year Revision 1.3 Jun 24, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.nameRevision 1.4 Jul 8, 2020 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first / _citation.page_lastRevision 1.5 Oct 11, 2023 Group : Data collection / Database references ... Data collection / Database references / Derived calculations / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_conn / struct_ncs_dom_lim Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession ... _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_conn.pdbx_dist_value / _struct_conn.ptnr1_auth_asym_id / _struct_conn.ptnr1_auth_comp_id / _struct_conn.ptnr1_auth_seq_id / _struct_conn.ptnr1_label_asym_id / _struct_conn.ptnr1_label_atom_id / _struct_conn.ptnr1_label_comp_id / _struct_conn.ptnr1_label_seq_id / _struct_conn.ptnr2_auth_asym_id / _struct_conn.ptnr2_auth_comp_id / _struct_conn.ptnr2_auth_seq_id / _struct_conn.ptnr2_label_asym_id / _struct_conn.ptnr2_label_atom_id / _struct_conn.ptnr2_label_comp_id / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id
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