Entry Database : PDB / ID : 6mak Structure visualization Downloads & linksTitle HBO1 is required for the maintenance of leukaemia stem cells ComponentsBRD1 protein Histone acetyltransferase KAT7 DetailsKeywords antitumor protein/transferase / MYST domain / cancer inhibitor / ANTITUMOR PROTEIN / antitumor protein-transferase complexFunction / homology Function and homology informationFunction Domain/homology Component
histone H3K4 acetyltransferase activity / response to hydroxyurea / response to actinomycin D / response to dithiothreitol / response to anisomycin / DNA replication-dependent chromatin disassembly / response to sorbitol / positive regulation of hematopoietic stem cell proliferation / regulation of DNA biosynthetic process / histone H3K23 acetyltransferase activity ... histone H3K4 acetyltransferase activity / response to hydroxyurea / response to actinomycin D / response to dithiothreitol / response to anisomycin / DNA replication-dependent chromatin disassembly / response to sorbitol / positive regulation of hematopoietic stem cell proliferation / regulation of DNA biosynthetic process / histone H3K23 acetyltransferase activity / histone H4K12 acetyltransferase activity / histone H3K14 acetyltransferase activity / histone H4K5 acetyltransferase activity / histone H4K8 acetyltransferase activity / natural killer cell differentiation / histone H4 acetyltransferase activity / internal peptidyl-lysine acetylation / histone H3 acetyltransferase activity / regulation of nucleotide-excision repair / stress-activated protein kinase signaling cascade / positive regulation of DNA-templated transcription, elongation / histone H3-K14 acetyltransferase complex / regulation of DNA-templated DNA replication initiation / regulation of developmental process / regulation of hemopoiesis / MOZ/MORF histone acetyltransferase complex / histone reader activity / positive regulation of DNA replication / erythrocyte maturation / regulation of DNA replication / site of DNA damage / DNA replication origin binding / chromosome, centromeric region / response to immobilization stress / histone acetyltransferase complex / response to electrical stimulus / histone acetyltransferase activity / histone acetyltransferase / transcription coregulator activity / Regulation of TP53 Activity through Acetylation / transcription initiation-coupled chromatin remodeling / positive regulation of erythrocyte differentiation / regulation of cell growth / positive regulation of protein localization to nucleus / chromosome / HATs acetylate histones / histone binding / DNA replication / perikaryon / chromatin remodeling / regulation of cell cycle / nuclear speck / DNA repair / chromatin binding / dendrite / regulation of transcription by RNA polymerase II / chromatin / regulation of DNA-templated transcription / zinc ion binding / nucleoplasm / nucleus / metal ion binding / cytosol Similarity search - Function Zinc finger, C2H2C-type superfamily / Zinc finger, C2HC type / Zinc finger, C2H2C-type / Zinc finger CCHHC-type profile. / : / MYST, zinc finger domain / MYST family zinc finger domain / Histone acetyltransferase domain, MYST-type / MOZ/SAS family / MYST-type histone acetyltransferase (HAT) domain profile. ... Zinc finger, C2H2C-type superfamily / Zinc finger, C2HC type / Zinc finger, C2H2C-type / Zinc finger CCHHC-type profile. / : / MYST, zinc finger domain / MYST family zinc finger domain / Histone acetyltransferase domain, MYST-type / MOZ/SAS family / MYST-type histone acetyltransferase (HAT) domain profile. / BRPF2, ePHD domain / BRPF2, PHD domain / : / Enhancer of polycomb-like, N-terminal / Enhancer of polycomb-like / PHD-finger / PHD-zinc-finger like domain / Extended PHD (ePHD) domain / Extended PHD (ePHD) domain profile. / domain with conserved PWWP motif / PWWP domain / PWWP domain profile. / PWWP domain / Zinc finger, PHD-type, conserved site / Acyl-CoA N-acyltransferase / Zinc finger PHD-type signature. / Zinc finger PHD-type profile. / Zinc finger, PHD-finger / Zinc finger, PHD-type / PHD zinc finger / Bromodomain, conserved site / Bromodomain signature. / Zinc finger, FYVE/PHD-type / Bromodomain profile. / bromo domain / Bromodomain / Bromodomain-like superfamily / Bromodomain / Zinc finger, RING/FYVE/PHD-type / Winged helix-like DNA-binding domain superfamily Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.13 Å DetailsAuthors Ren, B. / Peat, T.S. / Monahan, B. / Dawson, M. / Street, I. CitationJournal : Nature / Year : 2020Title : HBO1 is required for the maintenance of leukaemia stem cells.Authors: MacPherson, L. / Anokye, J. / Yeung, M.M. / Lam, E.Y.N. / Chan, Y.C. / Weng, C.F. / Yeh, P. / Knezevic, K. / Butler, M.S. / Hoegl, A. / Chan, K.L. / Burr, M.L. / Gearing, L.J. / Willson, T. ... Authors : MacPherson, L. / Anokye, J. / Yeung, M.M. / Lam, E.Y.N. / Chan, Y.C. / Weng, C.F. / Yeh, P. / Knezevic, K. / Butler, M.S. / Hoegl, A. / Chan, K.L. / Burr, M.L. / Gearing, L.J. / Willson, T. / Liu, J. / Choi, J. / Yang, Y. / Bilardi, R.A. / Falk, H. / Nguyen, N. / Stupple, P.A. / Peat, T.S. / Zhang, M. / de Silva, M. / Carrasco-Pozo, C. / Avery, V.M. / Khoo, P.S. / Dolezal, O. / Dennis, M.L. / Nuttall, S. / Surjadi, R. / Newman, J. / Ren, B. / Leaver, D.J. / Sun, Y. / Baell, J.B. / Dovey, O. / Vassiliou, G.S. / Grebien, F. / Dawson, S.J. / Street, I.P. / Monahan, B.J. / Burns, C.J. / Choudhary, C. / Blewitt, M.E. / Voss, A.K. / Thomas, T. / Dawson, M.A. History Deposition Aug 27, 2018 Deposition site : RCSB / Processing site : RCSBRevision 1.0 Dec 25, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Jan 22, 2020 Group : Database references / Category : citationItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.year
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