Entry Database : PDB / ID : 6ku0 Structure visualization Downloads & linksTitle Crystal structure of MyoVa-GTD in complex with MICAL1-GTBM ComponentsPeptide from [F-actin]-monooxygenase MICAL1 Unconventional myosin-Va DetailsKeywords PROTEIN BINDING / Complex / Cargo bindingFunction / homology Function and homology informationFunction Domain/homology Component
actomyosin, myosin complex part / establishment of endoplasmic reticulum localization to postsynapse / axo-dendritic protein transport / positive regulation of cellular response to insulin stimulus / endoplasmic reticulum localization / melanosome localization / hippocampal mossy fiber expansion / NADPH oxidase H202-forming activity / F-actin monooxygenase / NAD(P)H oxidase (H2O2-forming) ... actomyosin, myosin complex part / establishment of endoplasmic reticulum localization to postsynapse / axo-dendritic protein transport / positive regulation of cellular response to insulin stimulus / endoplasmic reticulum localization / melanosome localization / hippocampal mossy fiber expansion / NADPH oxidase H202-forming activity / F-actin monooxygenase / NAD(P)H oxidase (H2O2-forming) / sulfur oxidation / locomotion involved in locomotory behavior / reactive gliosis / melanin metabolic process / regulation of regulated secretory pathway / unconventional myosin complex / insulin-responsive compartment / melanosome transport / NAD(P)H oxidase H2O2-forming activity / developmental pigmentation / regulation of postsynaptic cytosolic calcium ion concentration / negative regulation of dopamine secretion / oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen / secretory granule localization / postsynaptic actin cytoskeleton / actin filament-based movement / Regulation of actin dynamics for phagocytic cup formation / hair follicle maturation / melanocyte differentiation / melanin biosynthetic process / actomyosin / regulation of exocytosis / vesicle transport along actin filament / actin filament depolymerization / negative regulation of synaptic transmission, glutamatergic / ATP-dependent protein binding / positive regulation of vascular associated smooth muscle cell migration / myosin complex / long-chain fatty acid biosynthetic process / insulin secretion / syntaxin-1 binding / odontogenesis / intermediate filament / pigmentation / intercellular bridge / microfilament motor activity / dopamine metabolic process / exocytosis / cytoskeletal motor activity / actin filament bundle assembly / photoreceptor outer segment / smooth endoplasmic reticulum / vesicle-mediated transport / cytoskeleton organization / monooxygenase activity / visual perception / myelination / FAD binding / SNARE binding / negative regulation of protein phosphorylation / secretory granule / protein localization to plasma membrane / actin filament / macroautophagy / actin filament organization / positive regulation of protein localization to plasma membrane / synapse organization / Schaffer collateral - CA1 synapse / recycling endosome / small GTPase binding / SH3 domain binding / cellular response to insulin stimulus / calcium-dependent protein binding / disordered domain specific binding / actin filament binding / melanosome / actin cytoskeleton / synaptic vesicle / actin binding / Factors involved in megakaryocyte development and platelet production / midbody / postsynapse / protein-containing complex assembly / chemical synaptic transmission / vesicle / endosome membrane / calmodulin binding / ribonucleoprotein complex / axon / neuronal cell body / glutamatergic synapse / calcium ion binding / dendrite / protein-containing complex binding / negative regulation of apoptotic process / protein kinase binding / Golgi apparatus / signal transduction / ATP binding / identical protein binding Similarity search - Function DUF3585 / bMERB domain / Bivalent Mical/EHBP Rab binding domain / bMERB domain profile. / Myosin 5a, cargo-binding domain / Class V myosin, motor domain / Dilute domain / DIL domain / Dilute domain profile. / DIL ... DUF3585 / bMERB domain / Bivalent Mical/EHBP Rab binding domain / bMERB domain profile. / Myosin 5a, cargo-binding domain / Class V myosin, motor domain / Dilute domain / DIL domain / Dilute domain profile. / DIL / LIM zinc-binding domain signature. / LIM domain / Zinc-binding domain present in Lin-11, Isl-1, Mec-3. / Zinc finger, LIM-type / LIM domain profile. / IQ calmodulin-binding motif / FAD-binding domain / FAD binding domain / Myosin, N-terminal, SH3-like / Myosin N-terminal SH3-like domain profile. / Calponin homology domain / Calponin homology (CH) domain / Short calmodulin-binding motif containing conserved Ile and Gln residues. / Calponin homology domain / CH domain superfamily / Calponin homology (CH) domain profile. / Myosin head, motor domain / Myosin head (motor domain) / Myosin motor domain profile. / Myosin. Large ATPases. / IQ motif profile. / IQ motif, EF-hand binding site / Kinesin motor domain superfamily / FAD/NAD(P)-binding domain superfamily / P-loop containing nucleoside triphosphate hydrolase Similarity search - Domain/homologyBiological species Mus musculus (house mouse)Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.6 Å DetailsAuthors Niu, F. / Wei, Z. Funding support China, 3items Details Hide detailsOrganization Grant number Country National Natural Science Foundation of China 31800643 China National Natural Science Foundation of China 31770791 China National Natural Science Foundation of China 31570741 China
CitationJournal : Sci Adv / Year : 2020Title : F-actin disassembly factor MICAL1 binding to Myosin Va mediates cargo unloading during cytokinesis.Authors : Niu, F. / Sun, K. / Wei, W. / Yu, C. / Wei, Z. History Deposition Aug 29, 2019 Deposition site : PDBJ / Processing site : PDBJRevision 1.0 Sep 2, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Nov 18, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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