Entry Database : PDB / ID : 6ks0 Structure visualization Downloads & linksTitle Crystal structure of the human adiponectin receptor 1 ComponentsAdiponectin receptor protein 1 The heavy chain variable domain (Antibody) The light chain variable domain (Antibody) DetailsKeywords MEMBRANE PROTEIN/IMMUNE SYSTEM / membrane protein / MEMBRANE PROTEIN-IMMUNE SYSTEM complexFunction / homology Function and homology informationFunction Domain/homology Component
adiponectin binding / adipokinetic hormone receptor activity / adiponectin-activated signaling pathway / AMPK inhibits chREBP transcriptional activation activity / leptin-mediated signaling pathway / negative regulation of epithelial cell migration / negative regulation of receptor signaling pathway via JAK-STAT / negative regulation of epithelial to mesenchymal transition / negative regulation of non-canonical NF-kappaB signal transduction / fatty acid oxidation ... adiponectin binding / adipokinetic hormone receptor activity / adiponectin-activated signaling pathway / AMPK inhibits chREBP transcriptional activation activity / leptin-mediated signaling pathway / negative regulation of epithelial cell migration / negative regulation of receptor signaling pathway via JAK-STAT / negative regulation of epithelial to mesenchymal transition / negative regulation of non-canonical NF-kappaB signal transduction / fatty acid oxidation / regulation of lipid metabolic process / regulation of glucose metabolic process / positive regulation of insulin receptor signaling pathway / hormone-mediated signaling pathway / positive regulation of receptor signaling pathway via JAK-STAT / negative regulation of cell growth / glucose homeostasis / signaling receptor activity / positive regulation of cold-induced thermogenesis / protein kinase binding / identical protein binding / membrane / metal ion binding / plasma membrane Similarity search - FunctionBiological species Homo sapiens (human)Mus musculus (house mouse)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 2.79 Å DetailsAuthors Tanabe, H. / Fujii, Y. / Nakamura, Y. / Hosaka, T. / Okada-Iwabu, M. / Iwabu, M. / Kimura-Someya, T. / Shirouzu, M. / Yamauchi, T. / Kadowaki, T. / Yokoyama, S. Funding support Japan, 2items Details Hide detailsOrganization Grant number Country Japan Agency for Medical Research and Development (AMED) JP17am010108 Japan Ministry of Education, Culture, Sports, Science and Technology (Japan) 16K18509 Japan
CitationJournal : Commun Biol / Year : 2020Title : Human adiponectin receptor AdipoR1 assumes closed and open structures.Authors: Tanabe, H. / Fujii, Y. / Okada-Iwabu, M. / Iwabu, M. / Kano, K. / Kawana, H. / Hato, M. / Nakamura, Y. / Terada, T. / Kimura-Someya, T. / Shirouzu, M. / Kawano, Y. / Yamamoto, M. / Aoki, J. ... Authors : Tanabe, H. / Fujii, Y. / Okada-Iwabu, M. / Iwabu, M. / Kano, K. / Kawana, H. / Hato, M. / Nakamura, Y. / Terada, T. / Kimura-Someya, T. / Shirouzu, M. / Kawano, Y. / Yamamoto, M. / Aoki, J. / Yamauchi, T. / Kadowaki, T. / Yokoyama, S. History Deposition Aug 22, 2019 Deposition site : PDBJ / Processing site : PDBJSupersession Aug 19, 2020 ID : 3WXV Revision 1.0 Aug 19, 2020 Provider : repository / Type : Initial releaseRevision 1.1 Sep 16, 2020 Group : Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Nov 22, 2023 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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