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- PDB-6kr4: Crystal structure of the liprin-alpha3_SAM123/LAR_D1D2 complex -

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Basic information

Entry
Database: PDB / ID: 6kr4
TitleCrystal structure of the liprin-alpha3_SAM123/LAR_D1D2 complex
Components
  • Liprin-alpha-3
  • Receptor-type tyrosine-protein phosphatase F
KeywordsTRANSFERASE/PROTEIN BINDING / Complex / Phosphatase / TRANSFERASE-PROTEIN BINDING complex
Function / homology
Function and homology information


epididymosome / Serotonin Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / Acetylcholine Neurotransmitter Release Cycle / Dopamine Neurotransmitter Release Cycle / Glutamate Neurotransmitter Release Cycle / chondroitin sulfate proteoglycan binding / Receptor-type tyrosine-protein phosphatases / cell surface receptor protein tyrosine phosphatase signaling pathway / neuron projection regeneration ...epididymosome / Serotonin Neurotransmitter Release Cycle / Norepinephrine Neurotransmitter Release Cycle / Acetylcholine Neurotransmitter Release Cycle / Dopamine Neurotransmitter Release Cycle / Glutamate Neurotransmitter Release Cycle / chondroitin sulfate proteoglycan binding / Receptor-type tyrosine-protein phosphatases / cell surface receptor protein tyrosine phosphatase signaling pathway / neuron projection regeneration / Receptor-type tyrosine-protein phosphatases / synaptic vesicle docking / synaptic membrane adhesion / transmembrane receptor protein tyrosine phosphatase activity / presynaptic active zone cytoplasmic component / Synaptic adhesion-like molecules / regulation of axon regeneration / neurotransmitter secretion / regulation of short-term neuronal synaptic plasticity / presynaptic active zone / synaptic vesicle exocytosis / peptidyl-tyrosine dephosphorylation / cell adhesion molecule binding / Insulin receptor recycling / protein-tyrosine-phosphatase / acrosomal vesicle / negative regulation of receptor binding / protein tyrosine phosphatase activity / synapse organization / cell migration / heparin binding / receptor complex / cell adhesion / neuron projection / neuronal cell body / glutamatergic synapse / synapse / protein-containing complex binding / extracellular exosome / plasma membrane / cytoplasm
Similarity search - Function
Liprin-alpha, SAM domain repeat 1 / Liprin-alpha, SAM domain repeat 2 / Liprin-alpha, SAM domain repeat 3 / LAR-interacting protein, Liprin / Transcription Factor, Ets-1 / SAM domain (Sterile alpha motif) / SAM domain (Sterile alpha motif) / Protein tyrosine phosphatase superfamily / Protein-Tyrosine Phosphatase; Chain A / SAM domain profile. ...Liprin-alpha, SAM domain repeat 1 / Liprin-alpha, SAM domain repeat 2 / Liprin-alpha, SAM domain repeat 3 / LAR-interacting protein, Liprin / Transcription Factor, Ets-1 / SAM domain (Sterile alpha motif) / SAM domain (Sterile alpha motif) / Protein tyrosine phosphatase superfamily / Protein-Tyrosine Phosphatase; Chain A / SAM domain profile. / Sterile alpha motif. / Protein tyrosine phosphatase, catalytic domain / Sterile alpha motif domain / PTP type protein phosphatase domain profile. / Immunoglobulin I-set / Immunoglobulin I-set domain / Protein-tyrosine phosphatase / Tyrosine-specific protein phosphatase, PTPase domain / Protein-tyrosine phosphatase, catalytic / Protein tyrosine phosphatase, catalytic domain motif / Tyrosine specific protein phosphatases active site. / Protein-tyrosine phosphatase, active site / Sterile alpha motif/pointed domain superfamily / Tyrosine-specific protein phosphatases domain / Tyrosine specific protein phosphatases domain profile. / Protein-tyrosine phosphatase-like / Fibronectin type III domain / Fibronectin type 3 domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Fibronectin type-III domain profile. / Fibronectin type III / Fibronectin type III superfamily / DNA polymerase; domain 1 / Immunoglobulin subtype / Immunoglobulin / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulin-like fold / Alpha-Beta Complex / Orthogonal Bundle / Mainly Alpha / Alpha Beta
Similarity search - Domain/homology
TRIETHYLENE GLYCOL / PHOSPHATE ION / Receptor-type tyrosine-protein phosphatase F / Liprin-alpha-3
Similarity search - Component
Biological speciesHomo sapiens (human)
Mus musculus (house mouse)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.85 Å
AuthorsXie, X. / Liang, M. / Luo, L. / Wei, Z.
Funding support China, 2items
OrganizationGrant numberCountry
National Natural Science Foundation of China31770791 China
National Natural Science Foundation of China31570741 China
CitationJournal: Nat Commun / Year: 2020
Title: Structural basis of liprin-alpha-promoted LAR-RPTP clustering for modulation of phosphatase activity.
Authors: Xie, X. / Luo, L. / Liang, M. / Zhang, W. / Zhang, T. / Yu, C. / Wei, Z.
History
DepositionAug 20, 2019Deposition site: PDBJ / Processing site: PDBJ
Revision 1.0Jan 15, 2020Provider: repository / Type: Initial release
Revision 1.1Jan 29, 2020Group: Database references / Category: citation / citation_author
Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name
Revision 1.2Nov 22, 2023Group: Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / struct_ncs_dom_lim
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession ..._database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Receptor-type tyrosine-protein phosphatase F
B: Receptor-type tyrosine-protein phosphatase F
C: Receptor-type tyrosine-protein phosphatase F
D: Receptor-type tyrosine-protein phosphatase F
E: Liprin-alpha-3
F: Liprin-alpha-3
H: Liprin-alpha-3
G: Liprin-alpha-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)415,72319
Polymers414,0828
Non-polymers1,64011
Water2,900161
1
A: Receptor-type tyrosine-protein phosphatase F
E: Liprin-alpha-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)103,9055
Polymers103,5212
Non-polymers3843
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
2
B: Receptor-type tyrosine-protein phosphatase F
F: Liprin-alpha-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)103,8104
Polymers103,5212
Non-polymers2892
Water362
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
3
C: Receptor-type tyrosine-protein phosphatase F
G: Liprin-alpha-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)103,9605
Polymers103,5212
Non-polymers4393
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
4
D: Receptor-type tyrosine-protein phosphatase F
H: Liprin-alpha-3
hetero molecules


Theoretical massNumber of molelcules
Total (without water)104,0485
Polymers103,5212
Non-polymers5273
Water181
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Unit cell
Length a, b, c (Å)250.378, 147.678, 143.972
Angle α, β, γ (deg.)90.000, 103.850, 90.000
Int Tables number5
Space group name H-MC121
Noncrystallographic symmetry (NCS)NCS domain:
IDEns-IDDetails
11chain A
21chain B
31chain C
41chain D
12chain E
22chain F
32chain H

NCS domain segments:

Component-ID: 1

Dom-IDEns-IDBeg auth comp-IDBeg label comp-IDEnd auth comp-IDEnd label comp-IDSelection detailsAuth asym-IDLabel asym-IDAuth seq-IDLabel seq-ID
11HISHISTYRTYRchain AAA1328 - 19051 - 578
21HISHISASPASPchain BBB1328 - 19031 - 576
31HISHISHISHISchain CCC1328 - 19041 - 577
41HISHISTYRTYRchain DDD1328 - 19051 - 578
12ALAALALEULEUchain EEE806 - 11165 - 315
22LYSLYSARGARGchain FFF807 - 11146 - 313
32ALAALAILEILEchain HHG806 - 11085 - 307

NCS ensembles :
ID
1
2

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Components

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Protein , 2 types, 8 molecules ABCDEFHG

#1: Protein
Receptor-type tyrosine-protein phosphatase F / Leukocyte common antigen related / LAR


Mass: 66584.641 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: PTPRF, LAR / Plasmid: modified pET-32a / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P10586, protein-tyrosine-phosphatase
#2: Protein
Liprin-alpha-3 / Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3 / PTPRF- ...Protein tyrosine phosphatase receptor type f polypeptide-interacting protein alpha-3 / PTPRF-interacting protein alpha-3


Mass: 36935.949 Da / Num. of mol.: 4
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Mus musculus (house mouse) / Gene: Ppfia3 / Plasmid: modified pET-28a / Production host: Escherichia coli BL21(DE3) (bacteria) / References: UniProt: P60469

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Non-polymers , 5 types, 172 molecules

#3: Chemical ChemComp-PG4 / TETRAETHYLENE GLYCOL


Mass: 194.226 Da / Num. of mol.: 3 / Source method: obtained synthetically / Formula: C8H18O5 / Comment: precipitant*YM
#4: Chemical
ChemComp-PO4 / PHOSPHATE ION


Mass: 94.971 Da / Num. of mol.: 5 / Source method: obtained synthetically / Formula: PO4
#5: Chemical ChemComp-PGE / TRIETHYLENE GLYCOL


Mass: 150.173 Da / Num. of mol.: 2 / Source method: obtained synthetically / Formula: C6H14O4
#6: Chemical ChemComp-P6G / HEXAETHYLENE GLYCOL / POLYETHYLENE GLYCOL PEG400


Mass: 282.331 Da / Num. of mol.: 1 / Source method: obtained synthetically / Formula: C12H26O7 / Comment: precipitant*YM
#7: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 161 / Source method: isolated from a natural source / Formula: H2O

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Details

Has ligand of interestN

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 3.12 Å3/Da / Density % sol: 60.58 %
Crystal growTemperature: 296 K / Method: vapor diffusion, sitting drop / pH: 7.5
Details: 50mM Tris-HCl, 200mM NaCl, 1mM ethylenediaminetetraacetic acid, 1mM dithiothreitol

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: SSRF / Beamline: BL19U1 / Wavelength: 0.98 Å
DetectorType: DECTRIS PILATUS3 6M / Detector: PIXEL / Date: Nov 5, 2017
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.98 Å / Relative weight: 1
ReflectionResolution: 2.85→50 Å / Num. obs: 118298 / % possible obs: 99.7 % / Redundancy: 8.2 % / Biso Wilson estimate: 65.09 Å2 / Rmerge(I) obs: 0.15 / Rpim(I) all: 0.055 / Rrim(I) all: 0.16 / Χ2: 0.937 / Net I/σ(I): 3.8
Reflection shell

Diffraction-ID: 1

Resolution (Å)Redundancy (%)Rmerge(I) obsNum. unique obsCC1/2Rpim(I) allRrim(I) allΧ2% possible all
2.85-2.98.61.06858720.7440.3831.1370.52499.9
2.9-2.958.60.89458860.80.3210.9520.52499.9
2.95-3.018.60.76358820.8410.2730.8120.54299.9
3.01-3.078.60.6259060.8810.2230.660.55599.9
3.07-3.148.50.50859450.9120.1840.5410.57499.8
3.14-3.218.30.43158760.9290.1570.4590.60199.9
3.21-3.298.20.3659160.9450.1320.3840.629100
3.29-3.387.90.30459450.9570.1140.3260.68399.9
3.38-3.487.40.25258490.9630.0970.2710.75399.8
3.48-3.598.40.23559110.9760.0850.250.815100
3.59-3.726.80.26158890.9360.1090.2841.83898.9
3.72-3.878.40.18159220.9850.0650.1920.8999.9
3.87-4.048.10.15659020.9880.0570.1671.17599.8
4.04-4.268.40.12359100.9910.0440.1311.09299.7
4.26-4.528.80.11159170.9940.0390.1181.21199.8
4.52-4.878.70.10259050.9940.0360.1081.23799.6
4.87-5.368.50.09759610.9940.0340.1031.14899.7
5.36-6.148.30.09559200.9930.0340.1011.05199.6
6.14-7.737.70.09359740.9930.0350.11.18299.7
7.73-5080.08960100.9920.0320.0951.94398.9

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Processing

Software
NameVersionClassification
PHENIX1.9_1692refinement
HKL-2000data scaling
PDB_EXTRACT3.25data extraction
HKL-2000data reduction
PHASERphasing
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 1LAR, 3TAC

1lar

3tac


Resolution: 2.85→42.173 Å / SU ML: 0.34 / Cross valid method: THROUGHOUT / σ(F): 1.34 / Phase error: 25.8
RfactorNum. reflection% reflection
Rfree0.2298 1992 1.69 %
Rwork0.1915 --
obs0.1922 117634 98.68 %
Solvent computationShrinkage radii: 0.9 Å / VDW probe radii: 1.11 Å
Displacement parametersBiso max: 291.03 Å2 / Biso mean: 81.9738 Å2 / Biso min: 21.49 Å2
Refinement stepCycle: final / Resolution: 2.85→42.173 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms24470 0 103 161 24734
Biso mean--94.73 48.78 -
Num. residues----3065
Refine LS restraints
Refine-IDTypeDev idealNumber
X-RAY DIFFRACTIONf_bond_d0.00725228
X-RAY DIFFRACTIONf_angle_d0.92234170
X-RAY DIFFRACTIONf_chiral_restr0.0443704
X-RAY DIFFRACTIONf_plane_restr0.0054420
X-RAY DIFFRACTIONf_dihedral_angle_d12.3419383
Refine LS restraints NCS
Ens-IDDom-IDAuth asym-IDNumberRefine-IDRmsType
11A11041X-RAY DIFFRACTION6.669TORSIONAL
12B11041X-RAY DIFFRACTION6.669TORSIONAL
13C11041X-RAY DIFFRACTION6.669TORSIONAL
14D11041X-RAY DIFFRACTION6.669TORSIONAL
21E3590X-RAY DIFFRACTION6.669TORSIONAL
22F3590X-RAY DIFFRACTION6.669TORSIONAL
23H3590X-RAY DIFFRACTION6.669TORSIONAL
LS refinement shell

Refine-ID: X-RAY DIFFRACTION / Rfactor Rfree error: 0

Resolution (Å)Rfactor RfreeNum. reflection RfreeRfactor RworkNum. reflection Rwork% reflection obs (%)
2.85-2.9160.30961330.2704773293
2.916-2.99480.29611430.25968326100
2.9948-3.08290.28481440.2438334100
3.0829-3.18240.27261430.23048292100
3.1824-3.29610.31811430.23068361100
3.2961-3.4280.26781450.22528341100
3.428-3.58390.25371420.21198339100
3.5839-3.77280.2561430.224815598
3.7728-4.0090.19641430.18438354100
4.009-4.31820.1931440.16138361100
4.3182-4.75230.17421430.15168322100
4.7523-5.43870.24491450.1638375100
5.4387-6.84740.24471440.1953838399
6.8474-42.1730.19311370.1698796793
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
11.1819-0.24230.15662.40840.67731.66880.0091-0.0840.01470.01720.01720.02520.05270.102-0.02020.3231-0.0350.02480.26340.03050.324119.195444.8938141.3342
23.4304-0.9443-0.11032.4470.07432.5777-0.1119-0.4632-0.08810.3850.1534-0.01890.01790.0009-0.03910.43380.09430.01010.30090.02770.361421.57946.8868149.9436
32.1940.6212-0.63273.3822-1.13373.8464-0.01980.0645-0.0741-0.1590.12370.20510.0205-0.2173-0.10760.28210.0823-0.03520.2361-0.01510.319414.674611.5143135.1021
43.0425-1.29050.39073.54910.16363.2165-0.14810.130.39150.0862-0.1864-0.5301-0.1390.34290.32110.65530.01170.03930.64040.15170.429433.6279.076788.1299
52.52660.250.64892.3744-0.33374.895-0.4185-0.22310.79170.13-0.24830.2866-0.6418-0.34620.5820.64330.1811-0.19430.6609-0.1210.84028.37828.86371.3038
61.6985-0.1110.71391.94140.29932.9014-0.1990.08320.1225-0.23110.02970.2493-0.2494-0.03970.16060.4214-0.0845-0.10040.290.04230.47248.754963.9992117.951
73.7747-0.82124.6042.2588-0.07895.97530.01430.72650.1014-0.5393-0.03350.42040.18360.43180.1070.5736-0.1664-0.05570.66360.02260.66863.512153.432992.229
83.175-0.3853-0.40783.651-0.03263.5831-0.2207-0.1016-0.26540.08060.04010.22550.5599-0.31180.18390.6459-0.2246-0.08030.62950.00260.5659-19.475635.4676106.4028
94.50832.4619-1.3652.8992-0.83992.8528-0.28680.38030.3388-0.33690.17440.4651-0.1186-0.41590.11410.5303-0.1226-0.21120.5880.0210.6572-19.124649.277297.0522
103.7628-0.5669-0.24613.0797-0.17242.3882-0.03360.0745-0.2799-0.2418-0.13110.15520.28480.04850.16350.53460.07290.03430.40760.0030.300225.5628-16.6307107.6367
113.3133-0.24390.14293.64770.52096.2970.47260.39290.2701-0.9731-0.24311.4072-0.386-1.137-0.23571.08650.092-0.28380.846-0.0181.3824-3.8998-33.718993.9034
124.58420.57652.34875.42093.59453.33090.4432-1.12470.7211-1.0704-0.98852.44711.3845-2.22830.51131.5661-0.373-0.6452.00770.31622.0242-10.059113.8132123.5887
136.01931.33672.04591.82621.48013.9039-0.20460.9209-0.2782-0.1921-0.48761.5670.6446-1.59360.44340.7149-0.1452-0.03171.1258-0.31971.4004-11.0798-2.6805134.4434
143.7374-1.3591-1.6464.70692.19645.0971-0.1073-0.3148-0.01040.06940.04640.2515-0.2331-0.6380.10220.43470.11770.06970.88650.0970.6177-15.827520.9351157.7751
151.5295-1.2191.49061.1977-1.45096.07061.74010.3589-1.3585-0.32541.05220.99362.0381-1.0273-2.79952.5512-0.448-0.56451.54930.24292.0375-6.1852-1.575664.1194
165.39895.9495.49596.60276.0635.6043-0.3166-0.29880.57250.5762-0.45542.62411.5156-2.32310.82120.8523-0.32360.07621.2769-0.02921.2524-13.7624.626453.7621
176.572-0.02044.32854.16970.84799.19090.1241-0.1108-0.1708-0.5401-0.06650.57910.3145-0.4521-0.14920.8356-0.024-0.04261.0046-0.15640.9667-9.811615.300949.7839
187.853-1.62190.30554.10450.74694.592-0.06210.4101-0.73520.0844-0.1673-0.27671.52270.23950.20261.21170.11180.19720.8730.02460.613613.05073.400146.6387
199.0064-3.3668-0.9584.88411.18165.28140.01750.9909-0.1911-0.1517-0.0519-1.2251.47422.09950.01111.3030.62090.08061.88980.05631.313333.96830.900140.7079
201.6533-2.6890.42324.1678-0.91981.99430.18960.0082-0.0058-0.5727-0.04780.91380.7338-0.1932-0.04781.5377-0.2269-0.38590.78220.09441.13168.294-62.740597.5958
213.28061.455-2.4377.9662-0.88736.62840.40050.6698-0.6118-2.1078-0.07971.05861.88260.2866-0.4922.30830.1513-0.62730.9806-0.06351.19453.221-65.40682.9867
223.47040.9046-1.85494.6688-1.1153.07380.61660.46050.2625-2.5979-0.0603-0.08961.3660.8609-0.4251.77120.3391-0.0411.4802-0.09141.008416.0176-51.019979.1777
230.45350.23940.01691.5223-0.73533.32510.37790.8497-0.1196-0.58760.1651-0.3490.47581.2672-0.11573.09661.16320.25042.4695-0.23010.478625.5736-53.565772.6376
242.3466-1.36411.2022.4821-3.01345.5970.8849-0.228-0.6648-0.4315-0.0389-0.74092.10911.2077-0.67622.3520.7043-0.4112.1671-0.50250.864930.1391-57.523787.0023
251.6408-0.3677-0.54042.4722-0.18284.44710.57381.22250.6829-1.5789-0.154-1.78470.18591.6506-0.59812.15030.05070.69513.3052-0.06591.241836.1435-44.823579.4988
262.53270.76120.23680.2364-0.0090.60021.2130.80440.1878-1.2353-0.7828-1.291-0.59381.4647-0.39862.36680.6890.83593.1480.15191.453831.5484-44.4771.6642
271.286-0.4843-1.3280.25630.51021.96230.53413.41561.347-2.14390.4054-1.21120.36521.2071-1.16761.88110.48790.53343.6230.3951.860940.0741-41.004667.5972
283.20910.6214-2.59760.3253-0.28912.3418-0.25930.82580.2528-0.3253-0.5684-0.0928-0.0284-0.52790.3081.93210.4287-0.78051.58440.33611.6674-26.840161.472896.8523
290.5785-0.07271.10840.0109-0.14552.1353-0.26030.09690.1620.1526-0.1083-0.3166-0.16740.09990.26681.96050.3288-0.38443.1512-0.27631.3367-42.713954.694292.6244
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1chain 'A' and (resid 1328 through 1648 )A0
2X-RAY DIFFRACTION2chain 'A' and (resid 1649 through 1773 )A0
3X-RAY DIFFRACTION3chain 'A' and (resid 1774 through 1905 )A0
4X-RAY DIFFRACTION4chain 'B' and (resid 1328 through 1628 )B0
5X-RAY DIFFRACTION5chain 'B' and (resid 1629 through 1903 )B0
6X-RAY DIFFRACTION6chain 'C' and (resid 1328 through 1593 )C0
7X-RAY DIFFRACTION7chain 'C' and (resid 1594 through 1648 )C0
8X-RAY DIFFRACTION8chain 'C' and (resid 1649 through 1773 )C0
9X-RAY DIFFRACTION9chain 'C' and (resid 1774 through 1904 )C0
10X-RAY DIFFRACTION10chain 'D' and (resid 1328 through 1627 )D0
11X-RAY DIFFRACTION11chain 'D' and (resid 1628 through 1905 )D0
12X-RAY DIFFRACTION12chain 'E' and (resid 806 through 831 )E806 - 831
13X-RAY DIFFRACTION13chain 'E' and (resid 832 through 904 )E832 - 904
14X-RAY DIFFRACTION14chain 'E' and (resid 905 through 1116 )E905 - 1116
15X-RAY DIFFRACTION15chain 'F' and (resid 807 through 831 )F807 - 831
16X-RAY DIFFRACTION16chain 'F' and (resid 832 through 849 )F832 - 849
17X-RAY DIFFRACTION17chain 'F' and (resid 850 through 887 )F850 - 887
18X-RAY DIFFRACTION18chain 'F' and (resid 888 through 1053 )F888 - 1053
19X-RAY DIFFRACTION19chain 'F' and (resid 1054 through 1114 )F0
20X-RAY DIFFRACTION20chain 'H' and (resid 806 through 864 )H806 - 864
21X-RAY DIFFRACTION21chain 'H' and (resid 865 through 904 )H865 - 904
22X-RAY DIFFRACTION22chain 'H' and (resid 905 through 1000 )H905 - 1000
23X-RAY DIFFRACTION23chain 'H' and (resid 1001 through 1016 )H0
24X-RAY DIFFRACTION24chain 'H' and (resid 1017 through 1027 )H0
25X-RAY DIFFRACTION25chain 'H' and (resid 1028 through 1050 )H0
26X-RAY DIFFRACTION26chain 'H' and (resid 1051 through 1079 )H0
27X-RAY DIFFRACTION27chain 'H' and (resid 1080 through 1108 )H0
28X-RAY DIFFRACTION28chain 'G' and (resid 807 through 856 )G807 - 856
29X-RAY DIFFRACTION29chain 'G' and (resid 857 through 864 )G857 - 864

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