Entry | Database: PDB / ID: 6kj9 |
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Title | E. coli ATCase catalytic subunit mutant - G128/130A |
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Components | Aspartate carbamoyltransferase catalytic subunit |
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Keywords | TRANSFERASE / aspartate transcarbamoylase catalytic subunit / de novo pyrimidine biosynthesis |
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Function / homology | Function and homology information
aspartate carbamoyltransferase complex / aspartate carbamoyltransferase / aspartate carbamoyltransferase activity / amino acid binding / glutamine metabolic process / protein homotrimerization / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / identical protein binding / cytosol / cytoplasmSimilarity search - Function Aspartate carbamoyltransferase / Aspartate and ornithine carbamoyltransferases signature. / Aspartate/ornithine carbamoyltransferase / Aspartate/ornithine carbamoyltransferase, Asp/Orn-binding domain / Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding / Aspartate/ornithine carbamoyltransferase superfamily / Aspartate/ornithine carbamoyltransferase, Asp/Orn binding domain / Aspartate/ornithine carbamoyltransferase, carbamoyl-P binding domainSimilarity search - Domain/homology |
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Biological species | ![](img/tx_bacteria.gif) Escherichia coli K-12 (bacteria) |
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Method | X-RAY DIFFRACTION / MOLECULAR REPLACEMENT / Resolution: 2.5 Å |
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Authors | Lei, Z. / Zheng, J. / Jia, Z.C. |
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Funding support | China, Canada, 2items Organization | Grant number | Country |
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National Natural Science Foundation of China | 21773014 | China | Natural Sciences and Engineering Research Council (Canada) | RGPIN-2018-04427 | Canada |
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Citation | Journal: Febs J. / Year: 2020 Title: New regulatory mechanism-based inhibitors of aspartate transcarbamoylase for potential anticancer drug development. Authors: Lei, Z. / Wang, B. / Lu, Z. / Wang, N. / Tan, H. / Zheng, J. / Jia, Z. |
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History | Deposition | Jul 22, 2019 | Deposition site: PDBJ / Processing site: PDBJ |
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Revision 1.0 | Mar 11, 2020 | Provider: repository / Type: Initial release |
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Revision 1.1 | Aug 26, 2020 | Group: Database references / Category: citation Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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Revision 1.2 | Nov 22, 2023 | Group: Data collection / Database references / Refinement description Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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