登録情報 データベース : PDB / ID : 6j6y 構造の表示 ダウンロードとリンクタイトル FGFR4 D2 - Fab complex 要素Fab Heavy chain Fab light chain Fibroblast growth factor receptor 4 詳細キーワード TRANSFERASE/IMMUNE SYSTEM / Fab / TRANSFERASE-IMMUNE SYSTEM complex機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
FGFR4 mutant receptor activation / betaKlotho-mediated ligand binding / regulation of extracellular matrix disassembly / phosphate ion homeostasis / regulation of bile acid biosynthetic process / FGFR4 ligand binding and activation / fibroblast growth factor receptor activity / Phospholipase C-mediated cascade; FGFR4 / positive regulation of DNA biosynthetic process / positive regulation of catalytic activity ... FGFR4 mutant receptor activation / betaKlotho-mediated ligand binding / regulation of extracellular matrix disassembly / phosphate ion homeostasis / regulation of bile acid biosynthetic process / FGFR4 ligand binding and activation / fibroblast growth factor receptor activity / Phospholipase C-mediated cascade; FGFR4 / positive regulation of DNA biosynthetic process / positive regulation of catalytic activity / fibroblast growth factor binding / PI-3K cascade:FGFR4 / positive regulation of proteolysis / regulation of lipid metabolic process / PI3K Cascade / fibroblast growth factor receptor signaling pathway / SHC-mediated cascade:FGFR4 / Signaling by FGFR4 in disease / transport vesicle / FRS-mediated FGFR4 signaling / cholesterol homeostasis / Negative regulation of FGFR4 signaling / receptor protein-tyrosine kinase / peptidyl-tyrosine phosphorylation / Constitutive Signaling by Aberrant PI3K in Cancer / cell migration / PIP3 activates AKT signaling / glucose homeostasis / heparin binding / PI5P, PP2A and IER3 Regulate PI3K/AKT Signaling / RAF/MAP kinase cascade / protein autophosphorylation / positive regulation of ERK1 and ERK2 cascade / receptor complex / endosome / positive regulation of cell population proliferation / positive regulation of gene expression / Golgi apparatus / endoplasmic reticulum / extracellular region / ATP binding / plasma membrane 類似検索 - 分子機能 Fibroblast growth factor receptor family / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype ... Fibroblast growth factor receptor family / Immunoglobulin domain / Immunoglobulin I-set / Immunoglobulin I-set domain / Immunoglobulin subtype 2 / Immunoglobulin C-2 Type / Tyrosine-protein kinase, catalytic domain / Tyrosine kinase, catalytic domain / Tyrosine protein kinases specific active-site signature. / Immunoglobulin subtype / Immunoglobulin / Tyrosine-protein kinase, active site / Protein tyrosine and serine/threonine kinase / Serine-threonine/tyrosine-protein kinase, catalytic domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Immunoglobulin-like fold / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Immunoglobulin-like / Sandwich / Mainly Beta 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)synthetic construct (人工物) 手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.15 Å 詳細データ登録者 Takahashi, M. / Hanzawa, H. 引用ジャーナル : Mol.Cancer Ther. / 年 : 2019タイトル : Preclinical Development of U3-1784, a Novel FGFR4 Antibody Against Cancer, and Avoidance of Its On-target Toxicity.著者: Bartz, R. / Fukuchi, K. / Ohtsuka, T. / Lange, T. / Gruner, K. / Watanabe, I. / Hayashi, S. / Oda, Y. / Kawaida, R. / Komori, H. / Kashimoto, Y. / Wirtz, P. / Mayer, J.A. / Redondo-Muller, M. ... 著者 : Bartz, R. / Fukuchi, K. / Ohtsuka, T. / Lange, T. / Gruner, K. / Watanabe, I. / Hayashi, S. / Oda, Y. / Kawaida, R. / Komori, H. / Kashimoto, Y. / Wirtz, P. / Mayer, J.A. / Redondo-Muller, M. / Saito, S. / Takahashi, M. / Hanzawa, H. / Imai, E. / Martinez, A. / Hanai, M. / Haussinger, D. / Chapman, R.W. / Agatsuma, T. / Bange, J. / Abraham, R. 履歴 登録 2019年1月16日 登録サイト : PDBJ / 処理サイト : PDBJ改定 1.0 2019年8月7日 Provider : repository / タイプ : Initial release改定 1.1 2019年10月16日 Group : Data collection / Database references / カテゴリ : citation / citation_authorItem : _citation.journal_volume / _citation.page_first ... _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.title / _citation_author.identifier_ORCID
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