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- PDB-6ivx: Discovery of the Second Generation ROR gamma Inhibitors Composed ... -
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Basic information
Entry | Database: PDB / ID: 6ivx | ||||||
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Title | Discovery of the Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. | ||||||
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![]() | NUCLEAR PROTEIN/INHIBITOR / Ternary Complex / Nuclear Receptor / NUCLEAR PROTEIN / NUCLEAR PROTEIN-INHIBITOR complex / IMMUNE SYSTEM | ||||||
Function / homology | ![]() Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / T-helper 17 cell differentiation / ligand-activated transcription factor activity / cellular response to sterol / regulation of steroid metabolic process / nuclear glucocorticoid receptor binding / Peyer's patch development / positive regulation of circadian rhythm ...Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / T-helper 17 cell differentiation / ligand-activated transcription factor activity / cellular response to sterol / regulation of steroid metabolic process / nuclear glucocorticoid receptor binding / Peyer's patch development / positive regulation of circadian rhythm / oxysterol binding / T-helper cell differentiation / RUNX3 Regulates Immune Response and Cell Migration / negative regulation of thymocyte apoptotic process / Notch binding / regulation of fat cell differentiation / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / Notch-HLH transcription pathway / Regulation of MECP2 expression and activity / regulation of glucose metabolic process / estrous cycle / lymph node development / adipose tissue development / nuclear retinoid X receptor binding / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / : / lactation / transcription repressor complex / Regulation of lipid metabolism by PPARalpha / xenobiotic metabolic process / cerebellum development / SUMOylation of transcription cofactors / negative regulation of miRNA transcription / HDACs deacetylate histones / Downregulation of SMAD2/3:SMAD4 transcriptional activity / circadian regulation of gene expression / PPARA activates gene expression / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / DNA-binding transcription repressor activity, RNA polymerase II-specific / nuclear matrix / histone deacetylase binding / Transcriptional regulation of white adipocyte differentiation / Nuclear Receptor transcription pathway / HCMV Early Events / transcription corepressor activity / nuclear receptor activity / sequence-specific double-stranded DNA binding / response to estradiol / Interleukin-4 and Interleukin-13 signaling / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / membrane / nucleus Similarity search - Function | ||||||
Biological species | ![]() | ||||||
Method | ![]() ![]() ![]() | ||||||
![]() | Noguchi, M. / Nomura, A. / Doi, S. / Adachi, T. | ||||||
![]() | ![]() Title: Discovery of Second Generation ROR gamma Inhibitors Composed of an Azole Scaffold. Authors: Kotoku, M. / Maeba, T. / Fujioka, S. / Yokota, M. / Seki, N. / Ito, K. / Suwa, Y. / Ikenogami, T. / Hirata, K. / Hase, Y. / Katsuda, Y. / Miyagawa, N. / Arita, K. / Asahina, K. / Noguchi, M. ...Authors: Kotoku, M. / Maeba, T. / Fujioka, S. / Yokota, M. / Seki, N. / Ito, K. / Suwa, Y. / Ikenogami, T. / Hirata, K. / Hase, Y. / Katsuda, Y. / Miyagawa, N. / Arita, K. / Asahina, K. / Noguchi, M. / Nomura, A. / Doi, S. / Adachi, T. / Crowe, P. / Tao, H. / Thacher, S. / Hashimoto, H. / Suzuki, T. / Shiozaki, M. | ||||||
History |
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Structure visualization
Structure viewer | Molecule: ![]() ![]() |
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PDBx/mmCIF format | ![]() | 207.7 KB | Display | ![]() |
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-Validation report
Summary document | ![]() | 1.7 MB | Display | ![]() |
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Full document | ![]() | 1.7 MB | Display | |
Data in XML | ![]() | 35.2 KB | Display | |
Data in CIF | ![]() | 46.9 KB | Display | |
Arichive directory | ![]() ![]() | HTTPS FTP |
-Related structure data
Related structure data | ![]() 5x8qS S: Starting model for refinement |
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Similar structure data |
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Assembly
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: _ / Refine code: _
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