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Yorodumi- PDB-6a22: Ternary complex of Human ROR gamma Ligand Binding Domain With Com... -
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-Basic information
Entry | Database: PDB / ID: 6a22 | ||||||
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Title | Ternary complex of Human ROR gamma Ligand Binding Domain With Compound T. | ||||||
Components |
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Keywords | NUCLEAR PROTEIN/INHIBITOR / Ternary Complex / Nuclear Receptor / NUCLEAR PROTEIN / NUCLEAR PROTEIN-INHIBITOR complex | ||||||
Function / homology | Function and homology information Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / nuclear glucocorticoid receptor binding / T-helper 17 cell differentiation / ligand-activated transcription factor activity / cellular response to sterol / regulation of steroid metabolic process / Peyer's patch development / T-helper cell differentiation ...Loss of MECP2 binding ability to the NCoR/SMRT complex / negative regulation of androgen receptor signaling pathway / regulation of cellular ketone metabolic process / nuclear glucocorticoid receptor binding / T-helper 17 cell differentiation / ligand-activated transcription factor activity / cellular response to sterol / regulation of steroid metabolic process / Peyer's patch development / T-helper cell differentiation / positive regulation of circadian rhythm / oxysterol binding / RUNX3 Regulates Immune Response and Cell Migration / negative regulation of thymocyte apoptotic process / Notch binding / regulation of fat cell differentiation / NR1H2 & NR1H3 regulate gene expression to control bile acid homeostasis / Notch-HLH transcription pathway / Regulation of MECP2 expression and activity / estrous cycle / regulation of glucose metabolic process / lymph node development / adipose tissue development / nuclear retinoid X receptor binding / NR1H3 & NR1H2 regulate gene expression linked to cholesterol transport and efflux / response to organonitrogen compound / transcription repressor complex / lactation / Regulation of lipid metabolism by PPARalpha / xenobiotic metabolic process / cerebellum development / SUMOylation of transcription cofactors / negative regulation of miRNA transcription / HDACs deacetylate histones / Downregulation of SMAD2/3:SMAD4 transcriptional activity / circadian regulation of gene expression / PPARA activates gene expression / Cytoprotection by HMOX1 / NOTCH1 Intracellular Domain Regulates Transcription / Constitutive Signaling by NOTCH1 PEST Domain Mutants / Constitutive Signaling by NOTCH1 HD+PEST Domain Mutants / DNA-binding transcription repressor activity, RNA polymerase II-specific / nuclear matrix / Transcriptional regulation of white adipocyte differentiation / HCMV Early Events / Nuclear Receptor transcription pathway / histone deacetylase binding / transcription corepressor activity / nuclear receptor activity / sequence-specific double-stranded DNA binding / response to estradiol / Interleukin-4 and Interleukin-13 signaling / nuclear body / DNA-binding transcription factor activity, RNA polymerase II-specific / RNA polymerase II cis-regulatory region sequence-specific DNA binding / DNA-binding transcription factor activity / negative regulation of DNA-templated transcription / chromatin binding / chromatin / regulation of transcription by RNA polymerase II / positive regulation of DNA-templated transcription / negative regulation of transcription by RNA polymerase II / DNA binding / zinc ion binding / nucleoplasm / membrane / nucleus Similarity search - Function | ||||||
Biological species | Homo sapiens (human) | ||||||
Method | X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution: 2.55 Å | ||||||
Authors | Noguchi, M. / Nomura, A. / Doi, S. / Yamaguchi, K. / Adachi, T. | ||||||
Citation | Journal: Sci Rep / Year: 2018 Title: Ternary crystal structure of human ROR gamma ligand-binding-domain, an inhibitor and corepressor peptide provides a new insight into corepressor interaction Authors: Noguchi, M. / Nomura, A. / Doi, S. / Yamaguchi, K. / Hirata, K. / Shiozaki, M. / Maeda, K. / Hirashima, S. / Kotoku, M. / Yamaguchi, T. / Katsuda, Y. / Crowe, P. / Tao, H. / Thacher, S. / Adachi, T. | ||||||
History |
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-Structure visualization
Structure viewer | Molecule: MolmilJmol/JSmol |
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-Downloads & links
-Download
PDBx/mmCIF format | 6a22.cif.gz | 211.8 KB | Display | PDBx/mmCIF format |
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PDB format | pdb6a22.ent.gz | 169.7 KB | Display | PDB format |
PDBx/mmJSON format | 6a22.json.gz | Tree view | PDBx/mmJSON format | |
Others | Other downloads |
-Validation report
Arichive directory | https://data.pdbj.org/pub/pdb/validation_reports/a2/6a22 ftp://data.pdbj.org/pub/pdb/validation_reports/a2/6a22 | HTTPS FTP |
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-Related structure data
Related structure data | 5x8xS S: Starting model for refinement |
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Similar structure data |
-Links
-Assembly
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Unit cell |
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Noncrystallographic symmetry (NCS) | NCS domain:
NCS domain segments: Component-ID: 0 / Refine code: 0
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