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- PDB-6iap: structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4 -

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Basic information

Entry
Database: PDB / ID: 6iap
Titlestructure of human NKp46 in complex with antibody NKp46-1 and NKp46-4
Components
  • Fab NKp46-1 heavy chain
  • Fab NKp46-1 light chain
  • Fab NKp46-4 heavy chain
  • Fab NKp46-4 light chain
  • Natural cytotoxicity triggering receptor 1
KeywordsIMMUNE SYSTEM / THERAPEUTIC ANTIBODY
Function / homology
Function and homology information


regulation of natural killer cell mediated cytotoxicity / natural killer cell activation / SWI/SNF complex / cellular defense response / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / signal transduction / plasma membrane
Similarity search - Function
Immunoglobulin / Immunoglobulin domain / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / Mainly Beta
Similarity search - Domain/homology
Natural cytotoxicity triggering receptor 1
Similarity search - Component
Biological speciesHomo sapiens (human)
synthetic construct (others)
MethodX-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / molecular replacement / Resolution: 2.9 Å
AuthorsRoussel, A. / Amigues, B.
CitationJournal: Cell / Year: 2019
Title: Multifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.
Authors: Gauthier, L. / Morel, A. / Anceriz, N. / Rossi, B. / Blanchard-Alvarez, A. / Grondin, G. / Trichard, S. / Cesari, C. / Sapet, M. / Bosco, F. / Rispaud-Blanc, H. / Guillot, F. / Cornen, S. / ...Authors: Gauthier, L. / Morel, A. / Anceriz, N. / Rossi, B. / Blanchard-Alvarez, A. / Grondin, G. / Trichard, S. / Cesari, C. / Sapet, M. / Bosco, F. / Rispaud-Blanc, H. / Guillot, F. / Cornen, S. / Roussel, A. / Amigues, B. / Habif, G. / Caraguel, F. / Arrufat, S. / Remark, R. / Romagne, F. / Morel, Y. / Narni-Mancinelli, E. / Vivier, E.
History
DepositionNov 27, 2018Deposition site: PDBE / Processing site: PDBE
Revision 1.0Jun 12, 2019Provider: repository / Type: Initial release
Revision 1.1Jun 26, 2019Group: Data collection / Database references
Category: citation / database_PDB_rev / database_PDB_rev_record
Item: _citation.journal_volume / _citation.page_first / _citation.page_last
Revision 1.2Jan 24, 2024Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description
Category: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms
Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession

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Structure visualization

Structure viewerMolecule:
MolmilJmol/JSmol

Downloads & links

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Assembly

Deposited unit
A: Natural cytotoxicity triggering receptor 1
D: Fab NKp46-4 light chain
E: Fab NKp46-4 heavy chain
H: Fab NKp46-1 heavy chain
L: Fab NKp46-1 light chain


Theoretical massNumber of molelcules
Total (without water)113,7265
Polymers113,7265
Non-polymers00
Water2,864159
1


  • Idetical with deposited unit
  • defined by author&software
  • Evidence: gel filtration
TypeNameSymmetry operationNumber
identity operation1_555x,y,z1
Buried area10120 Å2
ΔGint-58 kcal/mol
Surface area45190 Å2
MethodPISA
Unit cell
Length a, b, c (Å)67.858, 73.827, 128.518
Angle α, β, γ (deg.)90.000, 90.570, 90.000
Int Tables number4
Space group name H-MP1211

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Components

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Antibody , 4 types, 4 molecules DEHL

#2: Antibody Fab NKp46-4 light chain


Mass: 23056.580 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Cricetulus griseus (Chinese hamster)
#3: Antibody Fab NKp46-4 heavy chain


Mass: 23192.908 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Cricetulus griseus (Chinese hamster)
#4: Antibody Fab NKp46-1 heavy chain


Mass: 23521.297 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Cricetulus griseus (Chinese hamster)
#5: Antibody Fab NKp46-1 light chain


Mass: 23244.791 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) synthetic construct (others) / Production host: Cricetulus griseus (Chinese hamster)

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Protein / Non-polymers , 2 types, 160 molecules A

#1: Protein Natural cytotoxicity triggering receptor 1 / Lymphocyte antigen 94 homolog / NK cell-activating receptor / Natural killer cell p46-related protein / hNKp46


Mass: 20710.625 Da / Num. of mol.: 1
Source method: isolated from a genetically manipulated source
Source: (gene. exp.) Homo sapiens (human) / Gene: NCR1, LY94 / Production host: Spodoptera frugiperda (fall armyworm) / References: UniProt: O76036
#6: Water ChemComp-HOH / water


Mass: 18.015 Da / Num. of mol.: 159 / Source method: isolated from a natural source / Formula: H2O

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Experimental details

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Experiment

ExperimentMethod: X-RAY DIFFRACTION / Number of used crystals: 1

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Sample preparation

CrystalDensity Matthews: 2.83 Å3/Da / Density % sol: 56.55 %
Crystal growTemperature: 293 K / Method: vapor diffusion, sitting drop
Details: 0.1M acid carboxylique, 0.1M Tris/bicine pH8.5, 50%P500MME/P20k

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Data collection

DiffractionMean temperature: 100 K / Serial crystal experiment: N
Diffraction sourceSource: SYNCHROTRON / Site: SOLEIL / Beamline: PROXIMA 1 / Wavelength: 0.97857 Å
DetectorType: DECTRIS PILATUS 6M / Detector: PIXEL / Date: Feb 7, 2018
RadiationProtocol: SINGLE WAVELENGTH / Monochromatic (M) / Laue (L): M / Scattering type: x-ray
Radiation wavelengthWavelength: 0.97857 Å / Relative weight: 1
ReflectionResolution: 2.89→48.47 Å / Num. obs: 28415 / % possible obs: 99.3 % / Redundancy: 3.4 % / Biso Wilson estimate: 81.39 Å2 / Net I/σ(I): 5.2
Reflection shellResolution: 2.89→3.05 Å / Num. unique obs: 28397

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Phasing

PhasingMethod: molecular replacement

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Processing

Software
NameVersionClassificationNB
BUSTER2.10.3refinement
XDSdata reduction
SCALAdata scaling
MOLREPphasing
PDB_EXTRACT3.24data extraction
RefinementMethod to determine structure: MOLECULAR REPLACEMENT
Starting model: 1OLL

1oll


Resolution: 2.9→48.47 Å / Cor.coef. Fo:Fc: 0.919 / Cor.coef. Fo:Fc free: 0.888 / Cross valid method: THROUGHOUT / σ(F): 0 / SU Rfree Blow DPI: 0.399
RfactorNum. reflection% reflectionSelection details
Rfree0.263 1399 4.93 %RANDOM
Rwork0.187 ---
obs0.191 28397 99.3 %-
Displacement parametersBiso max: 212.29 Å2 / Biso mean: 91.8 Å2 / Biso min: 44.45 Å2
Baniso -1Baniso -2Baniso -3
1--9.6439 Å20 Å2-22.2483 Å2
2--14.344 Å20 Å2
3----4.7001 Å2
Refine analyzeLuzzati coordinate error obs: 0.38 Å
Refinement stepCycle: final / Resolution: 2.9→48.47 Å
ProteinNucleic acidLigandSolventTotal
Num. atoms7979 0 0 159 8138
Biso mean---74.92 -
Num. residues----1041
Refine LS restraints
Refine-IDTypeNumberRestraint functionWeightDev ideal
X-RAY DIFFRACTIONt_dihedral_angle_d2695SINUSOIDAL2
X-RAY DIFFRACTIONt_trig_c_planes
X-RAY DIFFRACTIONt_gen_planes1363HARMONIC5
X-RAY DIFFRACTIONt_it8190HARMONIC20
X-RAY DIFFRACTIONt_nbd
X-RAY DIFFRACTIONt_improper_torsion
X-RAY DIFFRACTIONt_pseud_angle
X-RAY DIFFRACTIONt_chiral_improper_torsion1080SEMIHARMONIC5
X-RAY DIFFRACTIONt_sum_occupancies
X-RAY DIFFRACTIONt_utility_distance
X-RAY DIFFRACTIONt_utility_angle
X-RAY DIFFRACTIONt_utility_torsion
X-RAY DIFFRACTIONt_ideal_dist_contact8998SEMIHARMONIC4
X-RAY DIFFRACTIONt_bond_d8190HARMONIC20.01
X-RAY DIFFRACTIONt_angle_deg11150HARMONIC21.24
X-RAY DIFFRACTIONt_omega_torsion2.99
X-RAY DIFFRACTIONt_other_torsion21.07
LS refinement shellResolution: 2.9→2.92 Å / Rfactor Rfree error: 0 / Total num. of bins used: 50
RfactorNum. reflection% reflection
Rfree0.3792 31 5.46 %
Rwork0.2443 537 -
all0.251 568 -
obs--86.47 %
Refinement TLS params.

Method: refined / Refine-ID: X-RAY DIFFRACTION

IDL11 (°2)L12 (°2)L13 (°2)L22 (°2)L23 (°2)L33 (°2)S11 (Å °)S12 (Å °)S13 (Å °)S21 (Å °)S22 (Å °)S23 (Å °)S31 (Å °)S32 (Å °)S33 (Å °)T11 (Å2)T12 (Å2)T13 (Å2)T22 (Å2)T23 (Å2)T33 (Å2)Origin x (Å)Origin y (Å)Origin z (Å)
1-0.05760.11632.896803.33190.05760.0047-0.0877-0.221-0.23580.03180.13770.0472-0.1063-0.03650.02230.01020.0534-0.07830.1376-0.13417.306111.5582-24.6528
20.05961.1875-3.00675.21491.93322.06090.01380.2385-0.05830.1134-0.0143-0.12140.2666-0.11280.00050.3806-0.02350.1397-0.11080.06840.014923.715610.6953-30.0721
35.43652.7981-2.71264.0758-9.16718.87810.05060.1338-0.0450.09340.05920.12150.1054-0.0648-0.10980.03890.3249-0.07080.09470.25850.073730.163510.1346-33.216
41.50493.258-1.1213.7385-0.45737.4245-0.0396-0.1563-0.11080.0088-0.028-0.2120.07220.24450.06760.12380.0997-0.0017-0.14770.1431-0.012425.737110.1794-23.8782
5-0.02210.43421.1080.60392.30110.85190.0045-0.0299-0.2380.22760.0180.00850.0516-0.2464-0.02250.24910.02590.0278-0.19310.0931-0.135123.028615.6766-37.7103
60.0159-1.8664-0.34741.58562.136-0.00690.0386-0.2994-0.11390.10960.06010.2545-0.1559-0.5807-0.0987-0.05850.05720.14770.24810.2648-0.04456.512620.8055-5.4622
70.6096-1.05581.4781.72861.71220.0293-0.0374-0.2552-0.04920.33360.052-0.0728-0.268-0.2408-0.01460.00470.04740.05520.09220.0158-0.27610.127825.6382-4.8689
88.10121.49560.83030-7.79913.07820.0751-0.0068-0.3945-0.06150.05150.12820.303-0.0852-0.12650.07990.14090.04910.09030.24880.00935.404623.7538-9.7241
92.692-2.3059-0.6090-0.8647-0.0124-0.01640.02320.0373-0.20140.07410.24510.0833-0.1002-0.0577-0.06950.0349-0.00210.10090.32140.2726-1.460517.3105-7.6911
102.3657-4.39552.81521.2737-2.75180.0558-0.0316-0.0826-0.0577-0.29020.01360.0651-0.1064-0.14030.0180.09020.04270.0798-0.07770.1734-0.227115.525620.6194-7.1019
111.5036-0.2727-4.19494.4224-0.00675.7427-0.212-0.1891-0.37140.23260.1887-0.27810.28570.03620.02330.31530.13530.03610.0664-0.0240.195844.94134.2691-54.7822
121.46690.0418-1.97626.67462.00717.3087-0.10980.1988-0.1495-0.06920.0040.34190.0188-0.09530.10580.0512-0.03370.0755-0.1977-0.0564-0.05435.52510.5746-60.3773
133.7988-0.127-3.35963.69073.47245.9304-0.03790.0586-0.2070.21530.0931-0.07340.1787-0.1375-0.05520.16260.00570.1184-0.44470.0632-0.060840.25587.1554-57.8207
142.0067-2.4062-0.49775.29622.6967-0.0101-0.0455-0.1972-0.09720.18770.135-0.1771-0.02880.104-0.08950.0196-0.0762-0.0416-0.0735-0.02970.094649.178610.9705-61.5552
150.46392.88683.94210.5216.13850.07840.0569-0.20070.2808-0.0789-0.0167-0.2334-0.25650.3695-0.0402-0.057-0.18720.1057-0.2874-0.1220.064468.892428.9962-72.406
16-0.09820.19474.9291.4680.5680.8550.0463-0.1351-0.0522-0.08980.0727-0.00770.16240.3652-0.1189-0.1635-0.00670.06030.1019-0.09910.052474.370619.938-65.0449
17-0.0041.22531.38182.0764-2.70750.0275-0.0193-0.10160.0206-0.08130.02190.03230.12910.1759-0.00260.1898-0.29090.06110.0267-0.12450.006769.114525.3938-60.5614
180.25011.4975-0.83895.62330.8202-0.01670.1268-0.21420.175-0.14160.1018-0.0624-0.29620.2912-0.2286-0.0117-0.06590.1052-0.1833-0.13290.057364.112425.0413-69.1708
192.05082.1143-0.78090.6018-4.86650.09930.0603-0.07010.1616-0.0840.0917-0.11140.2570.2107-0.15190.0256-0.18530.15660.0705-0.14390.213979.057326.0736-68.3886
202.3551-0.4229-2.07870-4.00610.13370.0621-0.0592-0.0714-0.08280.0665-0.0791-0.12090.3558-0.1286-0.0222-0.02090.1027-0.1472-0.08190.163876.61319.8594-73.7506
210.0365-0.9997-1.83491.10332.3429-0.03650.0190.05350.1066-0.23610.11170.110.1266-0.245-0.13070.14190.03120.0249-0.19940.0874-0.107433.355731.0957-57.5096
223.9623-0.3919-1.71017.59780.1264.59280.0024-0.34510.1211-0.09620.2027-0.2656-0.20150.5178-0.20520.13330.00820.0278-0.2208-0.0649-0.223236.334429.2095-49.6314
23-0.0124-1.78650.60376.1512-0.07193.5639-0.03080.015-0.07460.2939-0.0450.1317-0.05310.09790.07580.0119-0.0084-0.0638-0.1355-0.0096-0.111535.221922.5305-42.5918
240.2871-1.1785-1.08030.13941.3498-0.01590.0118-0.1450.00910.11330.01850.0349-0.01590.0415-0.03030.1037-0.0414-0.10830.3704-0.04660.112744.424824.9069-37.3383
250.09772.8947-4.9261.29690.76412.8690.0212-0.12810.1659-0.19110.16130.0729-0.1330.137-0.18250.05160.03170.0811-0.2149-0.0958-0.013437.244332.5254-44.1582
264.4595-0.3088-1.95191.348-1.11133.41090.0305-0.220.3238-0.3140.074-0.2956-0.16450.0398-0.10450.2544-0.06630.1165-0.376-0.15460.124951.291729.6755-62.8216
273.0712-2.0591.18760.5326-3.26812.85280.2084-0.28980.6122-0.4443-0.16650.0967-0.0216-0.1747-0.04190.0839-0.15190.1376-0.2407-0.23020.257654.581635.1697-71.0964
2812.47642.8584-4.73318.181-1.9557-0.05990.05840.03780.1854-0.1786-0.0514-0.109-0.07910.0924-0.0070.0319-0.02630.0904-0.3254-0.08310.076261.027730.9806-72.1814
290.0589-0.4097-2.96142.9175-3.48410.6866-0.02020.0590.2668-0.1401-0.0537-0.009-0.0765-0.0340.07390.1362-0.03970.3189-0.2978-0.19080.351654.202541.3312-73.614
300.0365-0.0324-1.83520.8183-0.61260.0006-0.01070.0616-0.0128-0.0541-0.0091-0.0075-0.00610.07370.01980.3398-0.06510.0801-0.37350.06570.038964.758741.0367-80.4029
310.02040.53690.61920.4895-3.26282.0718-0.00510.166-0.1114-0.0308-0.0849-0.03180.0537-0.00490.09-0.0224-0.0206-0.12-0.01390.0097-0.100741.749515.840.7927
320.7022-0.0251-0.11940.416-1.17370.7679-0.00120.05720.0320.0222-0.00590.0062-0.1042-0.11780.00710.2816-0.0906-0.0402-0.0634-0.03490.150251.780833.33411.6322
331.965-3.1101-0.99280.5741-1.9112-0.01990.02950.20310.0306-0.3081-0.05320.1154-0.2675-0.09480.02370.09210.02950.0297-0.11380.0307-0.174236.931122.144-1.5752
342.43045.2066-2.23272.0906-0.7827-0.0447-0.0162-0.351-0.02440.10360.03520.0045-0.12520.1123-0.0190.02710.1294-0.18840.0484-0.1653-0.171935.744825.700314.7049
350.9043-1.994-2.41994.63790.4277-0.0482-0.0364-0.01650.47730.03160.14130.0525-0.2904-0.1605-0.10490.20410.1427-0.1222-0.2054-0.07390.059232.018632.30913.4745
362.36941.81782.00090.0154-1.30790.0396-0.0884-0.16340.27120.18150.0924-0.3008-0.4756-0.0094-0.00390.11540.02290.061-0.1645-0.0635-0.132538.174126.10255.9123
371.9631-2.12150.0761.9792-0.96135.5040.0273-0.09540.0796-0.3314-0.0621-0.257-0.5601-0.17170.03480.13450.06660.0447-0.20940.06980.045344.972421.907611.4173
388.93140.516-0.94778.08537.76665.4761-0.13720.3233-0.2697-0.00010.2187-0.02820.30750.2982-0.0815-0.0766-0.17290.11760.0587-0.1018-0.27862.37628.023824.0557
395.10330.87222.37174.34970.05355.65860.11030.412-0.2142-0.1693-0.05990.12740.16950.2528-0.0505-0.0711-0.11590.0386-0.0436-0.0305-0.141157.55127.817119.9187
402.98693.26361.54420.0141-0.53063.22780.03710.20520.2449-0.11680.12270.0379-0.07180.2903-0.15990.0869-0.1330.27440.0714-0.0567-0.211663.55759.547912.7523
410.0348-3.4849-1.75160.83832.51110.13240.0885-0.40190.14820.0858-0.20430.0151-0.4253-0.10410.1157-0.1583-0.00320.10750.17-0.0403-0.197126.989815.092525.5933
427.99723.8016-6.13193.72742.03716.77850.0771-0.1702-0.09280.2082-0.2050.03330.096-0.34480.12790.03030.0910.13940.6778-0.0163-0.060419.678914.556919.9062
430.20242.5486-0.75973.3705-4.85213.0777-0.0588-0.19520.06740.07990.0738-0.1664-0.0154-0.0041-0.0151-0.1512-0.0755-0.02310.2046-0.003-0.207432.12411.260513.8071
445.6864.17413.29542.8884-6.49420.68420.078-0.3896-0.23980.15080.10160.10360.2452-0.31-0.1795-0.0895-0.06220.09290.19440.0572-0.064621.06638.464913.9444
451.38160.61691.92755.9195-0.53735.60190.0458-0.2946-0.08840.0454-0.1666-0.0332-0.3592-0.66610.1208-0.1427-0.02950.17690.1590.0718-0.293428.134213.048218.4542
460.0253-2.7292-1.28471.1927-0.60263.01160.0151-0.0088-0.1356-0.30820.14750.00310.15630.1259-0.16260.0314-0.0906-0.04040.0038-0.0551-0.130254.56062.860130.948
471.5576-0.45874.34621.071.22586.30250.0110.1226-0.0243-0.14410.19540.0970.08870.0043-0.2064-0.0108-0.03330.1199-0.14770.01370.004759.223410.011635.6844
480.2445-0.1669-2.37433.19120.61722.1467-0.0546-0.07410.265-0.14440.2722-0.03140.2183-0.2681-0.21760.0105-0.09010.05280.05380.02270.01348.8718.313628.3335
495.10991.6993-1.45371.49930.8923.52630.022-0.03280.05370.02810.1081-0.096-0.06640.2621-0.1301-0.0358-0.0256-0.06480.02620.09420.031961.54159.423837.3807
500.02651.5226-1.33070-4.112-0.0265-0.00320.04110.0246-0.12170.0142-0.0905-0.12760.1545-0.0111-0.21980.0495-0.0151-0.0011-0.0352-0.116466.08163.854439.4778
Refinement TLS group
IDRefine-IDRefine TLS-IDSelection detailsAuth asym-IDAuth seq-ID
1X-RAY DIFFRACTION1{ A|1 - 18 }A1 - 18
2X-RAY DIFFRACTION2{ A|19 - 39 }A19 - 39
3X-RAY DIFFRACTION3{ A|40 - 51 }A40 - 51
4X-RAY DIFFRACTION4{ A|52 - 71 }A52 - 71
5X-RAY DIFFRACTION5{ A|72 - 87 }A72 - 87
6X-RAY DIFFRACTION6{ A|88 - 117 }A88 - 117
7X-RAY DIFFRACTION7{ A|118 - 133 }A118 - 133
8X-RAY DIFFRACTION8{ A|134 - 153 }A134 - 153
9X-RAY DIFFRACTION9{ A|154 - 167 }A154 - 167
10X-RAY DIFFRACTION10{ A|168 - 182 }A168 - 182
11X-RAY DIFFRACTION11{ D|1 - 31 }D1 - 31
12X-RAY DIFFRACTION12{ D|32 - 65 }D32 - 65
13X-RAY DIFFRACTION13{ D|66 - 94 }D66 - 94
14X-RAY DIFFRACTION14{ D|95 - 110 }D95 - 110
15X-RAY DIFFRACTION15{ D|111 - 140 }D111 - 140
16X-RAY DIFFRACTION16{ D|141 - 155 }D141 - 155
17X-RAY DIFFRACTION17{ D|156 - 162 }D156 - 162
18X-RAY DIFFRACTION18{ D|163 - 186 }D163 - 186
19X-RAY DIFFRACTION19{ D|187 - 198 }D187 - 198
20X-RAY DIFFRACTION20{ D|199 - 211 }D199 - 211
21X-RAY DIFFRACTION21{ E|1 - 10 }E1 - 10
22X-RAY DIFFRACTION22{ E|11 - 42 }E11 - 42
23X-RAY DIFFRACTION23{ E|43 - 61 }E43 - 61
24X-RAY DIFFRACTION24{ E|62 - 67 }E62 - 67
25X-RAY DIFFRACTION25{ E|68 - 89 }E68 - 89
26X-RAY DIFFRACTION26{ E|90 - 146 }E90 - 146
27X-RAY DIFFRACTION27{ E|147 - 166 }E147 - 166
28X-RAY DIFFRACTION28{ E|167 - 195 }E167 - 195
29X-RAY DIFFRACTION29{ E|196 - 212 }E196 - 212
30X-RAY DIFFRACTION30{ E|213 - 217 }E213 - 217
31X-RAY DIFFRACTION31{ H|1 - 8 }H1 - 8
32X-RAY DIFFRACTION32{ H|9 - 16 }H9 - 16
33X-RAY DIFFRACTION33{ H|17 - 35 }H17 - 35
34X-RAY DIFFRACTION34{ H|36 - 49 }H36 - 49
35X-RAY DIFFRACTION35{ H|50 - 73 }H50 - 73
36X-RAY DIFFRACTION36{ H|74 - 103 }H74 - 103
37X-RAY DIFFRACTION37{ H|104 - 128 }H104 - 128
38X-RAY DIFFRACTION38{ H|129 - 155 }H129 - 155
39X-RAY DIFFRACTION39{ H|156 - 198 }H156 - 198
40X-RAY DIFFRACTION40{ H|199 - 220 }H199 - 220
41X-RAY DIFFRACTION41{ L|1 - 15 }L1 - 15
42X-RAY DIFFRACTION42{ L|16 - 34 }L16 - 34
43X-RAY DIFFRACTION43{ L|35 - 49 }L35 - 49
44X-RAY DIFFRACTION44{ L|50 - 71 }L50 - 71
45X-RAY DIFFRACTION45{ L|72 - 104 }L72 - 104
46X-RAY DIFFRACTION46{ L|105 - 123 }L105 - 123
47X-RAY DIFFRACTION47{ L|124 - 156 }L124 - 156
48X-RAY DIFFRACTION48{ L|157 - 171 }L157 - 171
49X-RAY DIFFRACTION49{ L|172 - 203 }L172 - 203
50X-RAY DIFFRACTION50{ L|204 - 211 }L204 - 211

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