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Structure paper

TitleMultifunctional Natural Killer Cell Engagers Targeting NKp46 Trigger Protective Tumor Immunity.
Journal, issue, pagesCell, Vol. 177, Page 1701-1713.e16, Year 2019
Publish dateNov 27, 2018 (structure data deposition date)
AuthorsGauthier, L. / Morel, A. / Anceriz, N. / Rossi, B. / Blanchard-Alvarez, A. / Grondin, G. / Trichard, S. / Cesari, C. / Sapet, M. / Bosco, F. ...Gauthier, L. / Morel, A. / Anceriz, N. / Rossi, B. / Blanchard-Alvarez, A. / Grondin, G. / Trichard, S. / Cesari, C. / Sapet, M. / Bosco, F. / Rispaud-Blanc, H. / Guillot, F. / Cornen, S. / Roussel, A. / Amigues, B. / Habif, G. / Caraguel, F. / Arrufat, S. / Remark, R. / Romagne, F. / Morel, Y. / Narni-Mancinelli, E. / Vivier, E.
External linksCell / PubMed:31155232
MethodsX-ray diffraction
Resolution1.75 - 2.9 Å
Structure data

PDB-6iap:
structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4
Method: X-RAY DIFFRACTION / Resolution: 2.9 Å

PDB-6ias:
structure of human NKp46 in complex with antibody NKp46-1 and NKp46-4
Method: X-RAY DIFFRACTION / Resolution: 1.75 Å

Chemicals

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
  • synthetic construct (others)
KeywordsIMMUNE SYSTEM / THERAPEUTIC ANTIBODY

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