登録情報 | データベース: PDB / ID: 6hyo |
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タイトル | Structure of ULK1 LIR motif bound to GABARAP |
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要素 | Serine/threonine-protein kinase ULK1,Gamma-aminobutyric acid receptor-associated protein |
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キーワード | SIGNALING PROTEIN / Autophagy / ATG8 / LIR |
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機能・相同性 | 機能・相同性情報
omegasome membrane / neuron projection regeneration / regulation of protein lipidation / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / positive regulation of protein K48-linked ubiquitination / regulation of Rac protein signal transduction / positive regulation of autophagosome assembly / GABA receptor binding / phagophore assembly site membrane ...omegasome membrane / neuron projection regeneration / regulation of protein lipidation / negative regulation of collateral sprouting / Atg1/ULK1 kinase complex / positive regulation of protein K48-linked ubiquitination / regulation of Rac protein signal transduction / positive regulation of autophagosome assembly / GABA receptor binding / phagophore assembly site membrane / piecemeal microautophagy of the nucleus / cellular response to nitrogen starvation / RAB GEFs exchange GTP for GDP on RABs / phosphatidylethanolamine binding / regulation of tumor necrosis factor-mediated signaling pathway / axon extension / phagophore assembly site / TBC/RABGAPs / reticulophagy / microtubule associated complex / Macroautophagy / Receptor Mediated Mitophagy / beta-tubulin binding / response to starvation / axoneme / cellular response to nutrient levels / autophagosome membrane / autophagosome maturation / autophagosome assembly / extrinsic apoptotic signaling pathway via death domain receptors / smooth endoplasmic reticulum / autophagosome / regulation of macroautophagy / protein targeting / negative regulation of protein-containing complex assembly / positive regulation of autophagy / sperm midpiece / macroautophagy / Regulation of TNFR1 signaling / peptidyl-threonine phosphorylation / protein localization / recycling endosome / small GTPase binding / autophagy / microtubule cytoskeleton organization / neuron projection development / positive regulation of proteasomal ubiquitin-dependent protein catabolic process / protein transport / actin cytoskeleton / GTPase binding / cytoplasmic vesicle / microtubule binding / chemical synaptic transmission / peptidyl-serine phosphorylation / microtubule / mitochondrial outer membrane / protein autophosphorylation / lysosome / non-specific serine/threonine protein kinase / negative regulation of cell population proliferation / axon / Golgi membrane / protein phosphorylation / protein serine kinase activity / protein serine/threonine kinase activity / ubiquitin protein ligase binding / synapse / protein-containing complex binding / endoplasmic reticulum membrane / signal transduction / ATP binding / identical protein binding / plasma membrane / cytoplasm / cytosol類似検索 - 分子機能 Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / Autophagy protein Atg8 ubiquitin-like / Autophagy protein Atg8 ubiquitin like / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) ...Serine/threonine-protein kinase, Ulk1/Ulk2 / : / ATG1-like, MIT domain 2 / Serine/threonine-protein kinase Atg1-like, tMIT domain / Atg1-like, MIT domain 1 / Serine/threonine-protein kinase Atg1-like / Autophagy protein Atg8 ubiquitin-like / Autophagy protein Atg8 ubiquitin like / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Ubiquitin-like domain superfamily / Serine/threonine-protein kinase, active site / Serine/Threonine protein kinases active-site signature. / Protein kinase domain / Serine/Threonine protein kinases, catalytic domain / Roll / Protein kinase, ATP binding site / Protein kinases ATP-binding region signature. / Protein kinase domain profile. / Protein kinase domain / Protein kinase-like domain superfamily / Alpha Beta類似検索 - ドメイン・相同性 DI(HYDROXYETHYL)ETHER / Serine/threonine-protein kinase ULK1 / Gamma-aminobutyric acid receptor-associated protein類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.07 Å |
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データ登録者 | Mouilleron, S. / Wirth, M. / Zhang, W. / O'Reilly, N. / Tooze, S. / Johansen, T. / Razi, M. / Nyoni, L. / Joshi, D. |
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引用 | ジャーナル: Nat Commun / 年: 2019 タイトル: Molecular determinants regulating selective binding of autophagy adapters and receptors to ATG8 proteins. 著者: Wirth, M. / Zhang, W. / Razi, M. / Nyoni, L. / Joshi, D. / O'Reilly, N. / Johansen, T. / Tooze, S.A. / Mouilleron, S. |
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履歴 | 登録 | 2018年10月22日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年5月8日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年5月15日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_PubMed / _citation.title / _citation_author.identifier_ORCID / _citation_author.name |
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改定 1.2 | 2024年1月24日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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