登録情報 | データベース: PDB / ID: 6hol |
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タイトル | Structure of ATG14 LIR motif bound to GABARAPL1 |
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要素 | - Beclin 1-associated autophagy-related key regulator
- Gamma-aminobutyric acid receptor-associated protein-like 1
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キーワード | SIGNALING PROTEIN / Autophagy / ATG8 / LIR |
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機能・相同性 | 機能・相同性情報
extrinsic component of omegasome membrane / phosphatidylinositol 3-kinase inhibitor activity / regulation of triglyceride metabolic process / extrinsic component of phagophore assembly site membrane / phosphatidylinositol 3-kinase complex, class III / glycophagy / mitochondria-associated endoplasmic reticulum membrane contact site / response to mitochondrial depolarisation / Tat protein binding / regulation of protein complex stability ...extrinsic component of omegasome membrane / phosphatidylinositol 3-kinase inhibitor activity / regulation of triglyceride metabolic process / extrinsic component of phagophore assembly site membrane / phosphatidylinositol 3-kinase complex, class III / glycophagy / mitochondria-associated endoplasmic reticulum membrane contact site / response to mitochondrial depolarisation / Tat protein binding / regulation of protein complex stability / GABA receptor binding / phagophore assembly site membrane / protein targeting to lysosome / early endosome to late endosome transport / cellular response to nitrogen starvation / phosphatidylethanolamine binding / phagophore assembly site / phosphatidylinositol-3-phosphate biosynthetic process / post-transcriptional regulation of gene expression / Macroautophagy / autophagosome membrane docking / endosome to lysosome transport / beta-tubulin binding / axoneme / autophagosome membrane / mitophagy / autophagosome maturation / autophagosome assembly / autophagosome / regulation of macroautophagy / cellular response to glucose starvation / protein-membrane adaptor activity / cellular response to starvation / phagocytic vesicle / phosphatidylinositol 3-kinase/protein kinase B signal transduction / negative regulation of protein phosphorylation / macroautophagy / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / regulation of protein phosphorylation / cytoplasmic vesicle membrane / phospholipid binding / GTPase binding / microtubule / positive regulation of protein phosphorylation / ubiquitin protein ligase binding / endoplasmic reticulum membrane / SARS-CoV-2 activates/modulates innate and adaptive immune responses / Golgi apparatus / endoplasmic reticulum / cytosol類似検索 - 分子機能 UV radiation resistance protein/autophagy-related protein 14 / Vacuolar sorting 38 and autophagy-related subunit 14 / Autophagy protein Atg8 ubiquitin-like / Autophagy protein Atg8 ubiquitin like / Phosphatidylinositol 3-kinase Catalytic Subunit; Chain A, domain 1 / Ubiquitin-like (UB roll) / Ubiquitin-like domain superfamily / Roll / Alpha Beta類似検索 - ドメイン・相同性 Beclin 1-associated autophagy-related key regulator / Gamma-aminobutyric acid receptor-associated protein-like 1類似検索 - 構成要素 |
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生物種 | Homo sapiens (ヒト) |
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手法 | X線回折 / シンクロトロン / 分子置換 / 解像度: 1.4 Å |
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データ登録者 | Mouilleron, S. / Birgisdottir, A.B. / Bhujbal, Z. / Wirth, M. / Sjottem, E. / Evjen, G. / Zhang, W. / Lee, R. / O'Reilly, N. / Tooze, S. ...Mouilleron, S. / Birgisdottir, A.B. / Bhujbal, Z. / Wirth, M. / Sjottem, E. / Evjen, G. / Zhang, W. / Lee, R. / O'Reilly, N. / Tooze, S. / Lamark, T. / Johansen, T. |
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資金援助 | ノルウェー, 2件 組織 | 認可番号 | 国 |
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Research Council of Norway | 214448 | ノルウェー | Research Council of Norway | 249884 | ノルウェー |
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引用 | ジャーナル: Autophagy / 年: 2019 タイトル: Members of the autophagy class III phosphatidylinositol 3-kinase complex I interact with GABARAP and GABARAPL1 via LIR motifs. 著者: Birgisdottir, A.B. / Mouilleron, S. / Bhujabal, Z. / Wirth, M. / Sjottem, E. / Evjen, G. / Zhang, W. / Lee, R. / O'Reilly, N. / Tooze, S.A. / Lamark, T. / Johansen, T. |
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履歴 | 登録 | 2018年9月17日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2019年2月27日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2019年3月13日 | Group: Data collection / Database references カテゴリ: citation / citation_author / pdbx_database_proc Item: _citation.page_first / _citation.page_last / _citation_author.identifier_ORCID |
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改定 1.2 | 2019年7月10日 | Group: Data collection / Database references / カテゴリ: citation / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first / _citation.page_last |
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改定 1.3 | 2024年1月24日 | Group: Advisory / Data collection ...Advisory / Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model / pdbx_unobs_or_zero_occ_atoms Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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