登録情報 | データベース: PDB / ID: 6gy1 |
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タイトル | rat COMT in complex with inhibitor |
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要素 | Catechol O-methyltransferase |
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キーワード | TRANSFERASE / Magnesium Ion Binding / O-Methyltransferase Activity / Neurotransmitter Catabolic Process |
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機能・相同性 | 機能・相同性情報
Enzymatic degradation of dopamine by COMT / Enzymatic degradation of Dopamine by monoamine oxidase / positive regulation of homocysteine metabolic process / Methylation / norepinephrine secretion / response to dopamine / mastication / catechol-containing compound metabolic process / catecholamine catabolic process / catechol O-methyltransferase activity ...Enzymatic degradation of dopamine by COMT / Enzymatic degradation of Dopamine by monoamine oxidase / positive regulation of homocysteine metabolic process / Methylation / norepinephrine secretion / response to dopamine / mastication / catechol-containing compound metabolic process / catecholamine catabolic process / catechol O-methyltransferase activity / renal sodium excretion / : / : / S-adenosylhomocysteine metabolic process / catechol O-methyltransferase / renal filtration / developmental process / renin secretion into blood stream / dopamine secretion / negative regulation of dopamine metabolic process / renal albumin absorption / catecholamine metabolic process / habituation / artery development / response to salt / short-term memory / S-adenosylmethionine metabolic process / cerebellar cortex morphogenesis / dopamine catabolic process / norepinephrine metabolic process / cellular response to phosphate starvation / glomerulus development / fear response / multicellular organismal reproductive process / synaptic transmission, dopaminergic / response to angiotensin / cellular response to cocaine / estrogen metabolic process / exploration behavior / response to food / cholesterol efflux / response to temperature stimulus / response to pain / response to corticosterone / prostaglandin metabolic process / glycogen metabolic process / dopamine metabolic process / startle response / detection of temperature stimulus involved in sensory perception of pain / : / behavioral fear response / multicellular organismal response to stress / response to amphetamine / : / learning / response to cytokine / kidney development / female pregnancy / negative regulation of smooth muscle cell proliferation / visual learning / multicellular organism growth / response to organic cyclic compound / response to toxic substance / memory / cognition / regulation of blood pressure / response to wounding / response to estrogen / gene expression / cell body / postsynapse / methylation / postsynaptic membrane / vesicle / response to oxidative stress / response to lipopolysaccharide / dendritic spine / learning or memory / response to hypoxia / response to xenobiotic stimulus / axon / glutamatergic synapse / dendrite / magnesium ion binding / membrane / cytosol類似検索 - 分子機能 Catechol O-methyltransferase, eukaryotic / O-methyltransferase / Class I-like SAM-dependent O-methyltransferase / SAM-dependent O-methyltransferase class I-type profile. / Vaccinia Virus protein VP39 / S-adenosyl-L-methionine-dependent methyltransferase superfamily / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta類似検索 - ドメイン・相同性 Chem-FGQ / S-ADENOSYL-L-HOMOCYSTEINE / Catechol O-methyltransferase類似検索 - 構成要素 |
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生物種 | ![](img/tx_mammal.gif) Rattus norvegicus (ドブネズミ) |
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手法 | X線回折 / 分子置換 / 解像度: 2.1 Å |
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データ登録者 | Schulze, M.-S. |
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引用 | ジャーナル: J. Med. Chem. / 年: 2018 タイトル: Optimization of 8-Hydroxyquinolines as Inhibitors of Catechol O-Methyltransferase. 著者: Buchler, I. / Akuma, D. / Au, V. / Carr, G. / de Leon, P. / DePasquale, M. / Ernst, G. / Huang, Y. / Kimos, M. / Kolobova, A. / Poslusney, M. / Wei, H. / Swinnen, D. / Montel, F. / Moureau, F. ...著者: Buchler, I. / Akuma, D. / Au, V. / Carr, G. / de Leon, P. / DePasquale, M. / Ernst, G. / Huang, Y. / Kimos, M. / Kolobova, A. / Poslusney, M. / Wei, H. / Swinnen, D. / Montel, F. / Moureau, F. / Jigorel, E. / Schulze, M.E.D. / Wood, M. / Barrow, J.C. |
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履歴 | 登録 | 2018年6月27日 | 登録サイト: PDBE / 処理サイト: PDBE |
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改定 1.0 | 2018年10月10日 | Provider: repository / タイプ: Initial release |
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改定 1.1 | 2018年11月21日 | Group: Data collection / Database references / Structure summary カテゴリ: citation / citation_author ...citation / citation_author / entity / pdbx_database_proc Item: _citation.journal_volume / _citation.page_first ..._citation.journal_volume / _citation.page_first / _citation.page_last / _citation_author.name / _entity.formula_weight |
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改定 1.2 | 2024年1月17日 | Group: Data collection / Database references / Refinement description カテゴリ: chem_comp_atom / chem_comp_bond ...chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item: _database_2.pdbx_DOI / _database_2.pdbx_database_accession |
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