Entry Database : PDB / ID : 6gq3 Structure visualization Downloads & linksTitle Human asparagine synthetase (ASNS) in complex with 6-diazo-5-oxo-L-norleucine (DON) at 1.85 A resolution ComponentsAsparagine synthetase [glutamine-hydrolyzing] Details Keywords BIOSYNTHETIC PROTEIN / L-asparagine biosynthesis / breast cancer / inhibitor developmentFunction / homology Function and homology informationFunction Domain/homology Component
asparagine synthase (glutamine-hydrolysing) / L-asparagine biosynthetic process / asparagine synthase (glutamine-hydrolyzing) activity / asparagine biosynthetic process / Response of EIF2AK1 (HRI) to heme deficiency / Aspartate and asparagine metabolism / ATF4 activates genes in response to endoplasmic reticulum stress / glutamine metabolic process / Response of EIF2AK4 (GCN2) to amino acid deficiency / cellular response to glucose starvation ... asparagine synthase (glutamine-hydrolysing) / L-asparagine biosynthetic process / asparagine synthase (glutamine-hydrolyzing) activity / asparagine biosynthetic process / Response of EIF2AK1 (HRI) to heme deficiency / Aspartate and asparagine metabolism / ATF4 activates genes in response to endoplasmic reticulum stress / glutamine metabolic process / Response of EIF2AK4 (GCN2) to amino acid deficiency / cellular response to glucose starvation / positive regulation of mitotic cell cycle / negative regulation of apoptotic process / ATP binding / cytosol Similarity search - Function Asparagine synthase, glutamine-hydrolyzing / Asparagine synthase, N-terminal domain / Glutamine amidotransferase domain / Asparagine synthase / Asparagine synthase / Glutamine amidotransferase type 2 domain profile. / Glutamine amidotransferase type 2 domain / HUPs / Nucleophile aminohydrolases, N-terminal / Rossmann-like alpha/beta/alpha sandwich fold ... Asparagine synthase, glutamine-hydrolyzing / Asparagine synthase, N-terminal domain / Glutamine amidotransferase domain / Asparagine synthase / Asparagine synthase / Glutamine amidotransferase type 2 domain profile. / Glutamine amidotransferase type 2 domain / HUPs / Nucleophile aminohydrolases, N-terminal / Rossmann-like alpha/beta/alpha sandwich fold / Rossmann fold / 3-Layer(aba) Sandwich / Alpha Beta Similarity search - Domain/homologyBiological species Homo sapiens (human)Method X-RAY DIFFRACTION / SYNCHROTRON / MOLECULAR REPLACEMENT / Resolution : 1.85 Å DetailsAuthors Zhu, W. / Radadiya, A. / Bisson, C. / Jin, Y. / Nordin, B.E. / Imasaki, T. / Wenzel, S. / Sedelnikova, S.E. / Berry, A.H. / Nomanbhoy, T.K. ...Zhu, W. / Radadiya, A. / Bisson, C. / Jin, Y. / Nordin, B.E. / Imasaki, T. / Wenzel, S. / Sedelnikova, S.E. / Berry, A.H. / Nomanbhoy, T.K. / Kozarich, J.W. / Takagi, Y. / Rice, D.W. / Richards, N.G.J. CitationJournal : Commun Biol / Year : 2019Title : High-resolution crystal structure of human asparagine synthetase enables analysis of inhibitor binding and selectivity.Authors: Zhu, W. / Radadiya, A. / Bisson, C. / Wenzel, S. / Nordin, B.E. / Martinez-Marquez, F. / Imasaki, T. / Sedelnikova, S.E. / Coricello, A. / Baumann, P. / Berry, A.H. / Nomanbhoy, T.K. / ... Authors : Zhu, W. / Radadiya, A. / Bisson, C. / Wenzel, S. / Nordin, B.E. / Martinez-Marquez, F. / Imasaki, T. / Sedelnikova, S.E. / Coricello, A. / Baumann, P. / Berry, A.H. / Nomanbhoy, T.K. / Kozarich, J.W. / Jin, Y. / Rice, D.W. / Takagi, Y. / Richards, N.G.J. History Deposition Jun 7, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Sep 18, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Oct 9, 2019 Group : Data collection / Database references / Category : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year Revision 1.2 Jan 17, 2024 Group : Data collection / Database references / Refinement descriptionCategory : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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