登録情報 データベース : PDB / ID : 6gk0 構造の表示 ダウンロードとリンクタイトル HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR 要素Dihydroorotate dehydrogenase (quinone), mitochondrial 詳細 キーワード ANTITUMOR PROTEIN / Dehydrogenase DHODH tumor-killing drug development機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane ... pyrimidine ribonucleotide biosynthetic process / dihydroorotate dehydrogenase (quinone) activity / dihydroorotate dehydrogenase (quinone) / dihydroorotate dehydrogenase activity / dihydroorotase activity / Pyrimidine biosynthesis / UDP biosynthetic process / 'de novo' UMP biosynthetic process / 'de novo' pyrimidine nucleobase biosynthetic process / mitochondrial inner membrane / mitochondrion / nucleoplasm / cytosol 類似検索 - 分子機能 Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel ... Dihydroorotate dehydrogenase, class 2 / Dihydroorotate dehydrogenase signature 1. / Dihydroorotate dehydrogenase signature 2. / Dihydroorotate dehydrogenase, conserved site / : / Dihydroorotate dehydrogenase domain / Dihydroorotate dehydrogenase / Aldolase class I / Aldolase-type TIM barrel / TIM Barrel / Alpha-Beta Barrel / Alpha Beta 類似検索 - ドメイン・相同性 ACETIC ACID / DECYLAMINE-N,N-DIMETHYL-N-OXIDE / Chem-DOR / Chem-F1W / FLAVIN MONONUCLEOTIDE / Dihydroorotate dehydrogenase (quinone), mitochondrial 類似検索 - 構成要素生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 解像度 : 1.85 Å 詳細データ登録者 Hakansson, M. / Ladds, M.J.G.W. / Walse, B. / Lain, S. 引用ジャーナル : J.Biol.Chem. / 年 : 2020タイトル : Exploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.著者 : Ladds, M.J.G.W. / Popova, G. / Pastor-Fernandez, A. / Kannan, S. / van Leeuwen, I.M.M. / Hakansson, M. / Walse, B. / Tholander, F. / Bhatia, R. / Verma, C.S. / Lane, D.P. / Lain, S. 履歴 登録 2018年5月17日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年11月27日 Provider : repository / タイプ : Initial release改定 1.1 2021年4月14日 Group : Database references / カテゴリ : citation / citation_authorItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_ASTM / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2024年5月15日 Group : Data collection / Database references / カテゴリ : chem_comp_atom / chem_comp_bond / database_2Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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