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Structure paper

TitleExploitation of dihydroorotate dehydrogenase (DHODH) and p53 activation as therapeutic targets: A case study in polypharmacology.
Journal, issue, pagesJ. Biol. Chem., Vol. 295, Page 17935-17949, Year 2020
Publish dateMay 17, 2018 (structure data deposition date)
AuthorsLadds, M.J.G.W. / Popova, G. / Pastor-Fernandez, A. / Kannan, S. / van Leeuwen, I.M.M. / Hakansson, M. / Walse, B. / Tholander, F. / Bhatia, R. / Verma, C.S. ...Ladds, M.J.G.W. / Popova, G. / Pastor-Fernandez, A. / Kannan, S. / van Leeuwen, I.M.M. / Hakansson, M. / Walse, B. / Tholander, F. / Bhatia, R. / Verma, C.S. / Lane, D.P. / Lain, S.
External linksJ. Biol. Chem. / PubMed:32900849
MethodsX-ray diffraction
Resolution1.85 Å
Structure data

PDB-6gk0:
HUMAN DIHYDROOROTATE DEHYDROGENASE IN COMPLEX WITH CLASS III HISTONE DEACETYLASE INHIBITOR
Method: X-RAY DIFFRACTION / Resolution: 1.85 Å

Chemicals

ChemComp-FMN:
FLAVIN MONONUCLEOTIDE

ChemComp-DOR:
(4S)-2,6-DIOXOHEXAHYDROPYRIMIDINE-4-CARBOXYLIC ACID

ChemComp-ACY:
ACETIC ACID

ChemComp-GOL:
GLYCEROL

ChemComp-SO4:
SULFATE ION

ChemComp-CL:
Unknown entry

ChemComp-DDQ:
DECYLAMINE-N,N-DIMETHYL-N-OXIDE

ChemComp-F1W:
4-~{tert}-butyl-~{N}-[[4-[5-(dimethylamino)pentanoylamino]phenyl]carbamothioyl]benzamide

ChemComp-HOH:
WATER

Source
  • homo sapiens (human)
KeywordsANTITUMOR PROTEIN / Dehydrogenase DHODH tumor-killing drug development

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