登録情報 データベース : PDB / ID : 6gjh 構造の表示 ダウンロードとリンクタイトル Human Hsp27 (HspB1) alpha-crystallin domain in complex with a peptide mimic of its phosphorylatable N-terminal region 要素ALA-LEU-SER-ARG ALA-LEU-SER-ARG-GLN Heat shock protein beta-1 LEU-SER-GLY-VAL 詳細キーワード CHAPERONE / Ig-fold / sHSP機能・相同性 機能・相同性情報分子機能 ドメイン・相同性 構成要素
anterograde axonal protein transport / cornified envelope / regulation of canonical NF-kappaB signal transduction / regulation of translational initiation / positive regulation of endothelial cell chemotaxis / protein kinase C inhibitor activity / response to unfolded protein / positive regulation of blood vessel endothelial cell migration / cellular response to vascular endothelial growth factor stimulus / vascular endothelial growth factor receptor signaling pathway ... anterograde axonal protein transport / cornified envelope / regulation of canonical NF-kappaB signal transduction / regulation of translational initiation / positive regulation of endothelial cell chemotaxis / protein kinase C inhibitor activity / response to unfolded protein / positive regulation of blood vessel endothelial cell migration / cellular response to vascular endothelial growth factor stimulus / vascular endothelial growth factor receptor signaling pathway / negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway / chaperone-mediated protein folding / axon cytoplasm / protein folding chaperone / proteasome complex / positive regulation of interleukin-1 beta production / ubiquitin binding / regulation of autophagy / AUF1 (hnRNP D0) binds and destabilizes mRNA / protein kinase C binding / regulation of protein phosphorylation / negative regulation of protein kinase activity / MAPK6/MAPK4 signaling / response to virus / platelet aggregation / VEGFA-VEGFR2 Pathway / Z disc / spindle / positive regulation of angiogenesis / positive regulation of tumor necrosis factor production / unfolded protein binding / protein refolding / response to heat / RNA polymerase II-specific DNA-binding transcription factor binding / Extra-nuclear estrogen signaling / cytoskeleton / intracellular signal transduction / focal adhesion / negative regulation of apoptotic process / protein kinase binding / protein homodimerization activity / RNA binding / extracellular space / extracellular exosome / identical protein binding / nucleus / cytosol / cytoplasm 類似検索 - 分子機能 Heat shock protein beta-1, ACD domain / Alpha crystallin/Small heat shock protein, animal type / Hsp20/alpha crystallin family / Small heat shock protein (sHSP) domain profile. / Alpha crystallin/Hsp20 domain / HSP20-like chaperone 類似検索 - ドメイン・相同性生物種 Homo sapiens (ヒト)手法 X線回折 / シンクロトロン / 分子置換 / 解像度 : 2.1 Å 詳細データ登録者 Collier, M.P. / Benesch, J.L.P. 資金援助 英国, 2件 詳細 詳細を隠す組織 認可番号 国 Biotechnology and Biological Sciences Research Council BB/K004247/1 英国 Biotechnology and Biological Sciences Research Council BB/J018082/1 英国
引用ジャーナル : Sci Adv / 年 : 2019タイトル : HspB1 phosphorylation regulates its intramolecular dynamics and mechanosensitive molecular chaperone interaction with filamin C.著者: Collier, M.P. / Alderson, T.R. / de Villiers, C.P. / Nicholls, D. / Gastall, H.Y. / Allison, T.M. / Degiacomi, M.T. / Jiang, H. / Mlynek, G. / Furst, D.O. / van der Ven, P.F.M. / Djinovic- ... 著者 : Collier, M.P. / Alderson, T.R. / de Villiers, C.P. / Nicholls, D. / Gastall, H.Y. / Allison, T.M. / Degiacomi, M.T. / Jiang, H. / Mlynek, G. / Furst, D.O. / van der Ven, P.F.M. / Djinovic-Carugo, K. / Baldwin, A.J. / Watkins, H. / Gehmlich, K. / Benesch, J.L.P. 履歴 登録 2018年5月16日 登録サイト : PDBE / 処理サイト : PDBE改定 1.0 2019年5月29日 Provider : repository / タイプ : Initial release改定 1.1 2019年6月12日 Group : Data collection / Database referencesカテゴリ : citation / citation_author / pdbx_database_procItem : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.journal_volume / _citation.page_first / _citation.page_last / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year 改定 1.2 2024年1月17日 Group : Data collection / Database references / Refinement descriptionカテゴリ : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / database_2 / pdbx_initial_refinement_model Item : _database_2.pdbx_DOI / _database_2.pdbx_database_accession
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