- PDB-6g9q: Ternary complex of P14 TCR with murine MHC class I H-2 Db in comp... -
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基本情報
登録情報
データベース: PDB / ID: 6g9q
タイトル
Ternary complex of P14 TCR with murine MHC class I H-2 Db in complex with self-antigen derived from dopamine monooxygenase.
要素
Beta-2-microglobulin
Dopamine beta-hydroxylase
H-2 class I histocompatibility antigen, D-B alpha chain
T cell receptor alpha variable 14-1,T-cell receptor alpha chain C region
T-cell receptor beta chain V region C5,T-cell receptor beta-1 chain C region
キーワード
IMMUNE SYSTEM / LCMV / cross-reactivity / MHC class I / TCR / APL
機能・相同性
機能・相同性情報
regulation of vascular associated smooth muscle cell proliferation / Catecholamine biosynthesis / octopamine metabolic process / dopamine beta-monooxygenase / leukocyte mediated immunity / dopamine beta-monooxygenase activity / octopamine biosynthetic process / homoiothermy / regulation of vascular endothelial cell proliferation / chromaffin granule lumen ...regulation of vascular associated smooth muscle cell proliferation / Catecholamine biosynthesis / octopamine metabolic process / dopamine beta-monooxygenase / leukocyte mediated immunity / dopamine beta-monooxygenase activity / octopamine biosynthetic process / homoiothermy / regulation of vascular endothelial cell proliferation / chromaffin granule lumen / regulation of extrinsic apoptotic signaling pathway / Phosphorylation of CD3 and TCR zeta chains / Translocation of ZAP-70 to Immunological synapse / PD-1 signaling / norepinephrine biosynthetic process / Generation of second messenger molecules / varicosity / chromaffin granule membrane / Downstream TCR signaling / behavioral response to ethanol / dopamine catabolic process / maternal behavior / alpha-beta T cell receptor complex / fear response / vasoconstriction / L-ascorbic acid binding / Endosomal/Vacuolar pathway / DAP12 interactions / Antigen Presentation: Folding, assembly and peptide loading of class I MHC / ER-Phagosome pathway / DAP12 signaling / Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell / transport vesicle membrane / T cell receptor complex / response to pain / leukocyte migration / associative learning / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-dependent / centriolar satellite / blood vessel remodeling / beta-2-microglobulin binding / cellular defense response / positive regulation of vasoconstriction / immunoglobulin complex, circulating / immunoglobulin receptor binding / response to amphetamine / Neutrophil degranulation / secretory granule membrane / locomotory behavior / complement activation, classical pathway / antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent / antigen processing and presentation of endogenous peptide antigen via MHC class Ib / lumenal side of endoplasmic reticulum membrane / antigen binding / peptide binding / response to bacterium / cellular response to iron(III) ion / antigen processing and presentation of exogenous protein antigen via MHC class Ib, TAP-dependent / negative regulation of forebrain neuron differentiation / visual learning / regulation of erythrocyte differentiation / peptide antigen assembly with MHC class I protein complex / regulation of iron ion transport / response to molecule of bacterial origin / MHC class I peptide loading complex / HFE-transferrin receptor complex / T cell mediated cytotoxicity / terminal bouton / antigen processing and presentation of endogenous peptide antigen via MHC class I / positive regulation of T cell cytokine production / memory / MHC class I protein complex / multicellular organismal-level iron ion homeostasis / negative regulation of neurogenesis / peptide antigen assembly with MHC class II protein complex / positive regulation of receptor-mediated endocytosis / MHC class II protein complex / cellular response to nicotine / positive regulation of T cell mediated cytotoxicity / phagocytic vesicle membrane / positive regulation of cellular senescence / peptide antigen binding / negative regulation of epithelial cell proliferation / antigen processing and presentation of exogenous peptide antigen via MHC class II / positive regulation of immune response / sensory perception of smell / positive regulation of T cell activation / apical part of cell / negative regulation of neuron projection development / MHC class II protein complex binding / glucose homeostasis / late endosome membrane / positive regulation of cold-induced thermogenesis / iron ion transport / antibacterial humoral response / T cell differentiation in thymus / cytoplasmic vesicle / protein refolding / protein homotetramerization / secretory granule lumen 類似検索 - 分子機能
Copper-dependent monooxygenases, DOMON domain / Dopamine beta-hydroxylase-like / Tyramine beta-hydroxylase/Dopamine beta-hydroxylase / DOMON domain profile. / DOMON domain / Possible catecholamine-binding domain present in a variety of eukaryotic proteins. / Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site / Copper type II, ascorbate-dependent monooxygenases signature 2. / Copper type II, ascorbate-dependent monooxygenase, N-terminal / Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site ...Copper-dependent monooxygenases, DOMON domain / Dopamine beta-hydroxylase-like / Tyramine beta-hydroxylase/Dopamine beta-hydroxylase / DOMON domain profile. / DOMON domain / Possible catecholamine-binding domain present in a variety of eukaryotic proteins. / Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-2 conserved site / Copper type II, ascorbate-dependent monooxygenases signature 2. / Copper type II, ascorbate-dependent monooxygenase, N-terminal / Copper type II, ascorbate-dependent monooxygenase, histidine-cluster-1 conserved site / Copper type II ascorbate-dependent monooxygenase, C-terminal / Copper type II, ascorbate-dependent monooxygenase, N-terminal domain superfamily / Copper type II ascorbate-dependent monooxygenase, N-terminal domain / Copper type II ascorbate-dependent monooxygenase, C-terminal domain / Copper type II, ascorbate-dependent monooxygenases signature 1. / PHM/PNGase F domain superfamily / Copper type II, ascorbate-dependent monooxygenase-like, C-terminal / T-cell receptor alpha chain, constant domain / Domain of unknown function (DUF1968) / MHC class I, alpha chain, C-terminal / MHC_I C-terminus / MHC class I-like antigen recognition-like / Murine Class I Major Histocompatibility Complex, H2-DB; Chain A, domain 1 / MHC class I alpha chain, alpha1 alpha2 domains / Class I Histocompatibility antigen, domains alpha 1 and 2 / Immunoglobulin V-Type / Beta-2-Microglobulin / MHC class I-like antigen recognition-like / MHC class I-like antigen recognition-like superfamily / Immunoglobulin V-set domain / MHC classes I/II-like antigen recognition protein / Immunoglobulin V-set domain / Immunoglobulin/major histocompatibility complex, conserved site / Immunoglobulins and major histocompatibility complex proteins signature. / Immunoglobulin subtype / Immunoglobulin / Immunoglobulin C-Type / Immunoglobulin C1-set / Immunoglobulin C1-set domain / Ig-like domain profile. / Immunoglobulin-like domain / Immunoglobulin-like domain superfamily / Immunoglobulins / Immunoglobulin-like fold / Immunoglobulin-like / Sandwich / 2-Layer Sandwich / Mainly Beta / Alpha Beta 類似検索 - ドメイン・相同性
T cell receptor alpha variable 14-1 / T-cell receptor alpha chain constant / T-cell receptor beta-1 chain C region / Beta-2-microglobulin / H-2 class I histocompatibility antigen, D-B alpha chain / T-cell receptor beta chain V region C5 / Dopamine beta-hydroxylase 類似検索 - 構成要素
A: H-2 class I histocompatibility antigen, D-B alpha chain B: Beta-2-microglobulin G: T cell receptor alpha variable 14-1,T-cell receptor alpha chain C region H: T-cell receptor beta chain V region C5,T-cell receptor beta-1 chain C region P: Dopamine beta-hydroxylase ヘテロ分子
解像度: 1.89→50.42 Å / Cor.coef. Fo:Fc: 0.959 / Cor.coef. Fo:Fc free: 0.938 / SU B: 8.686 / SU ML: 0.112 / 交差検証法: THROUGHOUT / ESU R: 0.235 / ESU R Free: 0.144 / 詳細: HYDROGENS HAVE BEEN ADDED IN THE RIDING POSITIONS