Entry Database : PDB / ID : 6flo Structure visualization Downloads & linksTitle Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1 Angstrom resolution ComponentsProtein kinase A regulatory subunit Details Keywords SIGNALING PROTEIN / Protein kinase A / Regulatory Subunit / Nucleoside-binding proteinFunction / homology Function and homology informationFunction Domain/homology Component
modulation of formation of structure involved in a symbiotic process / cilium movement involved in cell motility / cAMP-dependent protein kinase regulator activity / cAMP-dependent protein kinase complex / cilium / kinase activity / intracellular signal transduction / protein phosphorylation Similarity search - Function Cyclic nucleotide-binding domain signature 1. / Cyclic nucleotide-binding, conserved site / Cyclic nucleotide-monophosphate binding domain / Cyclic nucleotide-binding domain / cAMP/cGMP binding motif profile. / Cyclic nucleotide-binding domain / Cyclic nucleotide-binding domain superfamily / RmlC-like jelly roll fold / Leucine-rich repeat domain superfamily Similarity search - Domain/homologyBiological species Trypanosoma brucei brucei TREU927 (eukaryote)Method X-RAY DIFFRACTION / SYNCHROTRON / SAD / Resolution : 2.138686637 Å DetailsAuthors Volpato Santos, Y. / Lorentzen, E. / Basquin, J. / Boshart, M. Funding support Brazil, Germany, 2items Details Hide detailsOrganization Grant number Country Brazilian National Council for Scientific and Technological Development 233134/2014-0 Brazil German Research Foundation Bo1100/7-1 Germany
CitationJournal : Elife / Year : 2024Title : Purine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.Authors : Ober, V.T. / Githure, G.B. / Volpato Santos, Y. / Becker, S. / Moya Munoz, G. / Basquin, J. / Schwede, F. / Lorentzen, E. / Boshart, M. History Deposition Jan 26, 2018 Deposition site : PDBE / Processing site : PDBERevision 1.0 Aug 14, 2019 Provider : repository / Type : Initial releaseRevision 1.1 Dec 6, 2023 Group : Advisory / Data collection ... Advisory / Data collection / Database references / Refinement description Category : chem_comp_atom / chem_comp_bond ... chem_comp_atom / chem_comp_bond / citation / citation_author / database_2 / pdbx_unobs_or_zero_occ_atoms / struct_ncs_dom_lim Item : _citation.country / _citation.journal_abbrev ... _citation.country / _citation.journal_abbrev / _citation.journal_id_CSD / _citation.journal_id_ISSN / _citation.pdbx_database_id_DOI / _citation.title / _citation.year / _database_2.pdbx_DOI / _database_2.pdbx_database_accession / _struct_ncs_dom_lim.beg_auth_comp_id / _struct_ncs_dom_lim.beg_label_asym_id / _struct_ncs_dom_lim.beg_label_comp_id / _struct_ncs_dom_lim.beg_label_seq_id / _struct_ncs_dom_lim.end_auth_comp_id / _struct_ncs_dom_lim.end_label_asym_id / _struct_ncs_dom_lim.end_label_comp_id / _struct_ncs_dom_lim.end_label_seq_id Revision 1.2 Apr 10, 2024 Group : Database references / Source and taxonomyCategory : citation / citation_author ... citation / citation_author / entity_src_gen / struct_ref / struct_ref_seq Item : _citation.journal_volume / _citation.pdbx_database_id_DOI ... _citation.journal_volume / _citation.pdbx_database_id_DOI / _citation.pdbx_database_id_PubMed / _citation.title / _citation.year / _citation_author.identifier_ORCID / _citation_author.name / _entity_src_gen.pdbx_gene_src_gene / _struct_ref.db_code / _struct_ref.pdbx_db_accession / _struct_ref_seq.pdbx_db_accession
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