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TitlePurine nucleosides replace cAMP in allosteric regulation of PKA in trypanosomatid pathogens.
Journal, issue, pagesElife, Vol. 12, Year 2024
Publish dateJan 26, 2018 (structure data deposition date)
AuthorsOber, V.T. / Githure, G.B. / Volpato Santos, Y. / Becker, S. / Moya Munoz, G. / Basquin, J. / Schwede, F. / Lorentzen, E. / Boshart, M.
External linksElife / PubMed:38517938
MethodsX-ray diffraction
Resolution1.3994484654 - 2.14351698698 Å
Structure data

PDB-6flo:
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei at 2.1 Angstrom resolution
Method: X-RAY DIFFRACTION / Resolution: 2.138686637 Å

PDB-6h4g:
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma brucei: E311A, T318R, V319A mutant bound to cAMP in the A site
Method: X-RAY DIFFRACTION / Resolution: 2.14351698698 Å

PDB-6hyi:
Regulatory subunit of a cAMP-independent protein kinase A from Trypanosoma cruzi at 1.4 A resolution in complex with inosine
Method: X-RAY DIFFRACTION / Resolution: 1.3994484654 Å

Chemicals

ChemComp-NOS:
INOSINE

ChemComp-GOL:
GLYCEROL

ChemComp-HOH:
WATER

ChemComp-CMP:
ADENOSINE-3',5'-CYCLIC-MONOPHOSPHATE

Source
  • trypanosoma brucei brucei treu927 (eukaryote)
  • trypanosoma cruzi (eukaryote)
KeywordsSIGNALING PROTEIN / Protein kinase A / Regulatory Subunit / Nucleoside-binding protein / cell signalling

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